Phase transition of spindle-associated protein regulate spindle apparatus assembly.

abstract：:Signaling by TGF beta-related factors requires ligand-induced association between type I and type II transmembrane serine/threonine kinases. In Drosophila, the saxophone (sax) and thick veins (tkv) genes encode type I receptors that mediate signaling by decapentaplegic (dpp), a member of the bone morphogenetic protein...

journal_title：Cell

authors： Letsou A,Arora K,Wrana JL,Simin K,Twombly V,Jamal J,Staehling-Hampton K,Hoffmann FM,Gelbart WM,Massagué J

更新日期：1995-03-24 00:00:00

abstract：:Cloned, sequenced mouse satellite DNA exhibits properties characteristic of molecules that possess a stable curvature. Circularly permuted fragments containing the region predicted to bend were used to map the curvature relative to DNA sequence. The altered mobility of these fragments in polyacrylamide gels is reverse...

journal_title：Cell

authors： Radic MZ,Lundgren K,Hamkalo BA

更新日期：1987-09-25 00:00:00

abstract：:During the early stage of Ad2 infection of human cells, RNA is transcribed from five separate transcription units. Early region II encodes the mRNA for a 72K single-stranded DNA binding protein (DBP) which functions in DNA replication. This report describes the structure of the first leader of the DBP mRNA and the fla...

journal_title：Cell

authors： Baker CC,Herisse J,Courtois G,Galibert F,Ziff E

更新日期：1979-10-01 00:00:00

abstract：:The brightness of our visual environment varies tremendously from day to night. In this issue of Cell, Milner and Do describe how the population of retinal neurons responsible for entrainment of the brain's circadian clock cooperate to encode irradiance across a wide range of ambient-light intensities. ...

journal_title：Cell

authors： Varadarajan SG,Huberman AD

更新日期：2017-11-02 00:00:00

abstract：:Investigating the family tree of a tumor to identify its cellular origins is a daunting task. Liu et al. (2011) now use an elegant lineage tracing technique (MADM) to visualize glioma from its earliest stages. They show that mutations originally induced in neural stem cells lie dormant and only trigger malignant trans...

journal_title：Cell

authors： Sukhdeo K,Hambardzumyan D,Rich JN

更新日期：2011-07-22 00:00:00

abstract：:Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a mo...

journal_title：Cell

authors： Godar M,Lambrecht BN

更新日期：2016-01-14 00:00:00

abstract：:In causing disease, pathogens outmaneuver host defenses through a dedicated arsenal of virulence determinants that specifically bind or modify individual host molecules. This dedication limits the intruder to a defined range of hosts. Newly emerging diseases mostly involve existing pathogens whose arsenal has been alt...

journal_title：Cell

authors： Wollert T,Pasche B,Rochon M,Deppenmeier S,van den Heuvel J,Gruber AD,Heinz DW,Lengeling A,Schubert WD

更新日期：2007-06-01 00:00:00

abstract：:Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor So...

journal_title：Cell

authors： Klein R

更新日期：2010-10-01 00:00:00

abstract：:Cells producing avian sarcoma virus (ASV) contain at least three virus-specific mRNAs, two of which are encoded within the 3' half of the viral genome. Each of these viral RNAs can hybridize with single-stranded DNA(cDNA5') that is complementary to a sequence of 101 nucleotides found at the 5' terminus of the ASV geno...

journal_title：Cell

authors： Cordell B,Weiss SR,Varmus HE,Bishop JM

更新日期：1978-09-01 00:00:00

abstract：:A yeast gene homologous to bacterial RNase III (RNT1) encodes a double-strand-specific endoribonuclease essential for ribosome synthesis. Two rRNA processing events are blocked in cells temperature sensitive for RNT1: cleavage at the snoRNA-dependent AO site in the 5' ETS and cleavage in the 3' ETS. Recombinant RNT1 p...

journal_title：Cell

authors： Elela SA,Igel H,Ares M Jr

更新日期：1996-04-05 00:00:00

abstract：:In embryos of X. laevis, and many other species, early development requires targeted movements of molecules and molecular aggregates within the oocyte or egg cytoplasm. One well-known example in Xenopus is the aggregation of germ plasm, a group of cytoplasmic islands that become distributed during the first few cell c...

journal_title：Cell

authors： Robb DL,Heasman J,Raats J,Wylie C

更新日期：1996-11-29 00:00:00

abstract：:Bacterial flagella are driven by a rotary motor that utilizes the free energy stored in the electrochemical proton gradient across the cytoplasmic membrane to do mechanical work. The flux of protons coupled to motor rotation was measured in Streptococcus and found to be directly proportional to motor speed. This suppo...

journal_title：Cell

authors： Meister M,Lowe G,Berg HC

更新日期：1987-06-05 00:00:00

abstract：:Expression of human immunodeficiency virus type 1 structural proteins requires both the viral Rev trans-activator and its cis-acting RNA target sequence, the Rev response element (RRE). The RRE has been mapped to a conserved region of the HIV-1 env gene and is predicted to form a complex, highly stable RNA stem-loop s...

journal_title：Cell

authors： Malim MH,Tiley LS,McCarn DF,Rusche JR,Hauber J,Cullen BR

更新日期：1990-02-23 00:00:00

abstract：:The sulfated glycosaminoglycan, heparin, was found to release 125I-labeled low density lipoprotein (125I-LDL) from its receptor site on the surface of normal human fibroblasts. Measurement of the amount of 125I-LDL released by heparin permitted the resolution of the total cellular uptake of 125I-LDL at 37 degrees C in...

journal_title：Cell

authors： Goldstein JL,Basu SK,Brunschede GY,Brown MS

更新日期：1976-01-01 00:00:00

abstract：:BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a mutation in a residue that was essential for catalytic function in other helicases, interfered with normal double-strand break repair in a manner t...

journal_title：Cell

authors： Cantor SB,Bell DW,Ganesan S,Kass EM,Drapkin R,Grossman S,Wahrer DC,Sgroi DC,Lane WS,Haber DA,Livingston DM

更新日期：2001-04-06 00:00:00

abstract：:We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apoptotic cell death, which ...

journal_title：Cell

authors： Ahmed Y,Hayashi S,Levine A,Wieschaus E

更新日期：1998-06-26 00:00:00

abstract：:Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We id...

journal_title：Cell

authors： Stelzl U,Worm U,Lalowski M,Haenig C,Brembeck FH,Goehler H,Stroedicke M,Zenkner M,Schoenherr A,Koeppen S,Timm J,Mintzlaff S,Abraham C,Bock N,Kietzmann S,Goedde A,Toksöz E,Droege A,Krobitsch S,Korn B,Birchmeier W,

更新日期：2005-09-23 00:00:00

abstract：:The transport kinetics of the influenza virus hemagglutinin from its site of synthesis to the apical plasma membrane of Madin-Darby canine kidney cells, a polarized epithelial cell line, were studied by a sensitive tryptic assay. Hemagglutinin acquired terminal sugars, as judged by sensitivity to endo-beta-N-acetylglu...

journal_title：Cell

authors： Matlin KS,Simons K

更新日期：1983-08-01 00:00:00

abstract：:Rhythmic cardiac contractions depend on the organized propagation of depolarizing and repolarizing wavefronts. Repolarization is spatially heterogeneous and depends largely on gradients of potassium currents. Gradient disruption in heart disease may underlie susceptibility to fatal arrhythmias, but it is not known how...

journal_title：Cell

authors： Costantini DL,Arruda EP,Agarwal P,Kim KH,Zhu Y,Zhu W,Lebel M,Cheng CW,Park CY,Pierce SA,Guerchicoff A,Pollevick GD,Chan TY,Kabir MG,Cheng SH,Husain M,Antzelevitch C,Srivastava D,Gross GJ,Hui CC,Backx PH,Bruneau

更新日期：2005-10-21 00:00:00

abstract：:Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1, accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulat...

journal_title：Cell

authors： Yin Y,Vafeados D,Tao Y,Yoshida S,Asami T,Chory J

更新日期：2005-01-28 00:00:00

abstract：:Thyroid hormone (T3) and retinoic acid (RA) receptors mediate ligand-dependent inhibition of epidermal growth factor (EGF) receptor and c-erbB2/neu promoter activities. Ligand-activated T3 and RA receptors act via a 36 bp 5' fragment of the EGF receptor gene in vivo and, in the presence of nuclear extract, bind with h...

journal_title：Cell

authors： Hudson LG,Santon JB,Glass CK,Gill GN

更新日期：1990-09-21 00:00:00

abstract：:Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood. Here we characterize the transcriptional landscape of the four human HOX loci at five base pair resolution in 11 anatomic sites and identify 231 HOX ncRNAs that extend known transcribed regions by more than 30 kilobases. HOX ncRNAs ...

journal_title：Cell

authors： Rinn JL,Kertesz M,Wang JK,Squazzo SL,Xu X,Brugmann SA,Goodnough LH,Helms JA,Farnham PJ,Segal E,Chang HY

更新日期：2007-06-29 00:00:00

abstract：:Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse mode...

journal_title：Cell

authors： Osso LA,Chan JR

更新日期：2015-12-17 00:00:00

abstract：:Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets ...

journal_title：Cell

authors： Romanov N,Kuhn M,Aebersold R,Ori A,Beck M,Bork P

更新日期：2019-05-16 00:00:00

abstract：:In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular disease, the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) has emerged as a transcriptional regulator of metabolism whose activity can be modulated by direct binding of small molecules. As the master ...

journal_title：Cell

authors： Lehrke M,Lazar MA

更新日期：2005-12-16 00:00:00

abstract：:DNA carrying inverted repeats was tested for transposition within the Drosophila genome. Five Bam HI segments containing related inverted repeats were isolated from D. melanogaster and analyzed by electron microscopy and restriction mapping. Southern blot experiments using single-copy flanking sequences as probes allo...

journal_title：Cell

authors： Potter S,Truett M,Phillips M,Maher A

更新日期：1980-07-01 00:00:00

abstract：:DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify add...

journal_title：Cell

authors： Freudenthal BD,Beard WA,Shock DD,Wilson SH

更新日期：2013-07-03 00:00:00

abstract：:The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here, we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput single-cell RNA and VDJ sequencing of antigen-enriched B cells from 60 convalescent patients. From 8,558 antigen-binding IgG1+ clonotypes, 1...

journal_title：Cell

authors： Cao Y,Su B,Guo X,Sun W,Deng Y,Bao L,Zhu Q,Zhang X,Zheng Y,Geng C,Chai X,He R,Li X,Lv Q,Zhu H,Deng W,Xu Y,Wang Y,Qiao L,Tan Y,Song L,Wang G,Du X,Gao N,Liu J,Xiao J,Su XD,Du Z,Feng Y,Qin C,Qin C

更新日期：2020-07-09 00:00:00

abstract：:Oligodendrocyte-specific protein (OSP)/claudin-11 is a recently identified transmembrane protein found in CNS myelin and testis with unknown function. Herein we demonstrate that Osp null mice exhibit both neurological and reproductive deficits: CNS nerve conduction is slowed, hindlimb weakness is conspicuous, and male...

journal_title：Cell

authors： Gow A,Southwood CM,Li JS,Pariali M,Riordan GP,Brodie SE,Danias J,Bronstein JM,Kachar B,Lazzarini RA

更新日期：1999-12-10 00:00:00

abstract：:Subcellular compartments in which folding and assembly of proteins occur seem to have a set of PCB proteins capable of mediating these and related processes, such as translocation across membranes. When a domain of a polypeptide chain emerges from a ribosome during synthesis or from the distal side of a membrane durin...

journal_title：Cell

authors： Rothman JE

更新日期：1989-11-17 00:00:00