Abstract:
:In this issue of Cell, Lee et al. (2006) report that the parasite Trypanosoma brucei synthesizes fatty acids in an unconventional way. T. brucei and two other trypanosomes use enzymes called elongases to synthesize myristate, a fourteen carbon (C14) fatty acid essential for pathogenesis. This is an unexpected finding as these enzymes were thought only to elongate already long (C16 or C18) acyl chains.
journal_name
Celljournal_title
Cellauthors
Cronan JEdoi
10.1016/j.cell.2006.08.001subject
Has Abstractpub_date
2006-08-25 00:00:00pages
641-3issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(06)01011-7journal_volume
126pub_type
评论,杂志文章相关文献
CELL文献大全abstract::An agent that blocks tumor angiogenesis, growth, and metastasis without affecting normal tissues -- whether used alone or in combination with currently approved drugs -- would change the way we treat cancer. In this issue, Fischer et al. (2007) offer compelling evidence that a monoclonal antibody against placental gro...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2007.10.023
更新日期:2007-11-02 00:00:00
abstract::The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00607-9
更新日期:2001-12-28 00:00:00
abstract::Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a method for controlling gene expression based on Cas9, an RNA-guided DNA endonuclease from a type II CRISPR system. We show that a catalytically dead Cas9 lacking en...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.02.022
更新日期:2013-02-28 00:00:00
abstract::Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.12.022
更新日期:2017-01-26 00:00:00
abstract::An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the allele arose in centra...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.01.016
更新日期:2013-02-14 00:00:00
abstract::The human invariant chain (I gamma) of class II histocompatibility antigens spans the membrane of the endoplasmic reticulum once. It exposes a small amino-terminal domain on the cytoplasmic side and a carboxy-terminal, glycosylated domain on the exoplasmic side of the membrane. When the exoplasmic domain of I gamma is...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90710-5
更新日期:1986-09-26 00:00:00
abstract::We describe here a bizarre organization of the single large subunit (LSU) and small subunit (SSU) rRNA genes in the mitochondrial DNA of Chlamydomonas reinhardtii. Each gene is discontinuous, with gene pieces encoding specific rRNA domains ("modules") interspersed with one another and with intact protein coding and tR...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90026-8
更新日期:1988-11-04 00:00:00
abstract::Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether ensembles play a functional role in behavior. Some ensemble neurons have pattern completion properties, triggering the entire ensemble when activated. Using two-photon holographic optogenetics in mouse primary visual cortex, we ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.05.045
更新日期:2019-07-11 00:00:00
abstract::ARF GTPases act at multiple steps of the secretory and vacuolar/lysosomal trafficking pathways, but little is known about the spatial regulation of ARF activation. In this issue of Cell, Geldner et al. demonstrate that the Arabidopsis ARF activator GNOM localizes to endosomes where it controls the polarized traffickin...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/s0092-8674(03)00038-2
更新日期:2003-01-24 00:00:00
abstract::HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the class E proteins) also participate in HIV release, we identified 22 candidate human class E proteins. These proteins were connected ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00714-1
更新日期:2003-09-19 00:00:00
abstract::Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive bi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.02.013
更新日期:2017-02-23 00:00:00
abstract::Proliferating cell nuclear antigen (PCNA) is a cell cycle and growth regulated protein required for replication of SV40 DNA in vitro. Its function was investigated by comparison of the replication products synthesized in its presence or absence. In the completely reconstituted replication system that contains PCNA, DN...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90493-x
更新日期:1988-04-08 00:00:00
abstract::Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are particularly caused by endogenously produced reactive compounds such as formaldehyde, and also occur during compromised topoisomerase action. Although nucleotide excision repair and homologous recombination contribute to cell survival ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.04.053
更新日期:2014-07-17 00:00:00
abstract::During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2009.08.007
更新日期:2009-08-21 00:00:00
abstract::D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse development and in proliferation by generating mice lacking all D-cyclins. We found that these cyclin D1(-/-)D2(-/-)D3(-/-) mice develop u...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.07.025
更新日期:2004-08-20 00:00:00
abstract::Different hematopoietic cells produce minute amounts of beta-related interferon (IFN) following induction of differentiation by chemical or natural inducers. The endogenous IFN binds to type I cell surface receptors and modulates gene expression in the producer cells. We show that self-induction of two members of the ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90857-3
更新日期:1986-07-04 00:00:00
abstract::The nucleus is connected to the cytoskeleton, and these connections are involved in multiple functions such as nuclear positioning, shape and stiffness, cytoskeleton organization, mechanotransduction, gene expression, chromosome positioning, DNA repair, and cell migration. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.05.014
更新日期:2017-05-18 00:00:00
abstract::V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2010.04.014
更新日期:2010-04-30 00:00:00
abstract::During eukaryotic translation initiation, initiator tRNA does not insert fully into the P decoding site on the 40S ribosomal subunit. This conformation (POUT) is compatible with scanning mRNA for the AUG start codon. Base pairing with AUG is thought to promote isomerization to a more stable conformation (PIN) that arr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.10.001
更新日期:2014-10-23 00:00:00
abstract::The 2.6 Angstrom crystal structure for human cyclin-dependent kinase 2(CDK2) in complex with CksHs1, a human homolog of essential yeast cell cycle-regulatory proteins suc1 and Cks1, reveals that CksHs1 binds via all four beta strands to the kinase C-terminal lobe. This interface is biologically critical, based upon mu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81065-x
更新日期:1996-03-22 00:00:00
abstract::Vanadate has been shown to inhibit phosphatases that remove phosphate groups from phosphotyrosine in cell-free systems. Addition of vanadate to the culture medium of NRK-1 cells resulted in a maximal 40-fold increase in the level of phosphotyrosine in cell protein. Also, vanadate induced transformation as evidenced by...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(85)80051-9
更新日期:1985-07-01 00:00:00
abstract::A complex interplay of environmental factors impacts the metabolism of human cells, but neither traditional culture media nor mouse plasma mimic the metabolite composition of human plasma. Here, we developed a culture medium with polar metabolite concentrations comparable to those of human plasma (human plasma-like me...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.03.023
更新日期:2017-04-06 00:00:00
abstract::In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular disease, the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) has emerged as a transcriptional regulator of metabolism whose activity can be modulated by direct binding of small molecules. As the master ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2005.11.026
更新日期:2005-12-16 00:00:00
abstract::We have shown that lariat formation during in vitro splicing of several RNA precursors, from Drosophila to man, occurs at a unique and identifiable but weakly conserved site, 18 to 37 nucleotides proximal to the 3' splice site. Lariat formation within an artificial intron lacking a normal branch-point sequence occurs ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90064-9
更新日期:1985-05-01 00:00:00
abstract::To determine the function of c-fps in chicken macrophages and granulocytic cells we have infected chicken bone marrow cells with retroviruses containing the v-fps oncogene. Normal chicken macrophage progenitors, M-CFCs, give rise to macrophage colonies in semisolid cultures when macrophage colony stimulating factor (M...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90494-0
更新日期:1986-01-17 00:00:00
abstract::Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80712-6
更新日期:1999-04-02 00:00:00
abstract::T cells detect infection of cells by recognizing peptide fragments of foreign proteins bound to class I molecules of the major histocompatibility complex (MHC) on the surface of the infected cell. MHC class I molecules bind peptide in the endoplasmic reticulum, and analysis of mutant cells has demonstrated that an ade...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)80058-m
更新日期:1993-08-13 00:00:00
abstract::We have investigated whether histone H1 is present on active Balbiani ring genes in the salivary glands of Chironomus tentans using immunoelectron microscopy. The genes were studied in two activity states: maximally activated genes with a fully extended template and repressed genes in a 30 nm fiber conformation. Histo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90717-s
更新日期:1990-01-12 00:00:00
abstract::The v-erbB gene of avian erythroblastosis virus (AEV) codes for an integral plasma membrane glycoprotein, gp74erbB. Expression of gp74erbB and its intracellular precursors, gp66erbB and gp68erbB, has been studied in cells transformed by two temperature-sensitive mutants of AEV. After shift to 42 degrees C, the process...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90046-1
更新日期:1984-04-01 00:00:00
abstract::Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important drivers of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer mo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.11.018
更新日期:2021-01-07 00:00:00