Avant garde fatty acid synthesis by trypanosomes.

Abstract:

:In this issue of Cell, Lee et al. (2006) report that the parasite Trypanosoma brucei synthesizes fatty acids in an unconventional way. T. brucei and two other trypanosomes use enzymes called elongases to synthesize myristate, a fourteen carbon (C14) fatty acid essential for pathogenesis. This is an unexpected finding as these enzymes were thought only to elongate already long (C16 or C18) acyl chains.

journal_name

Cell

journal_title

Cell

authors

Cronan JE

doi

10.1016/j.cell.2006.08.001

subject

Has Abstract

pub_date

2006-08-25 00:00:00

pages

641-3

issue

4

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(06)01011-7

journal_volume

126

pub_type

评论,杂志文章

相关文献

CELL文献大全
  • alphaPlGF: a new kid on the antiangiogenesis block.

    abstract::An agent that blocks tumor angiogenesis, growth, and metastasis without affecting normal tissues -- whether used alone or in combination with currently approved drugs -- would change the way we treat cancer. In this issue, Fischer et al. (2007) offer compelling evidence that a monoclonal antibody against placental gro...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2007.10.023

    authors: Jain RK,Xu L

    更新日期:2007-11-02 00:00:00

  • Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.

    abstract::The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive ce...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(01)00607-9

    authors: Silver DL,Montell DJ

    更新日期:2001-12-28 00:00:00

  • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

    abstract::Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a method for controlling gene expression based on Cas9, an RNA-guided DNA endonuclease from a type II CRISPR system. We show that a catalytically dead Cas9 lacking en...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.02.022

    authors: Qi LS,Larson MH,Gilbert LA,Doudna JA,Weissman JS,Arkin AP,Lim WA

    更新日期:2013-02-28 00:00:00

  • Systemic Immunity Is Required for Effective Cancer Immunotherapy.

    abstract::Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2016.12.022

    authors: Spitzer MH,Carmi Y,Reticker-Flynn NE,Kwek SS,Madhireddy D,Martins MM,Gherardini PF,Prestwood TR,Chabon J,Bendall SC,Fong L,Nolan GP,Engleman EG

    更新日期:2017-01-26 00:00:00

  • Modeling recent human evolution in mice by expression of a selected EDAR variant.

    abstract::An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the allele arose in centra...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.01.016

    authors: Kamberov YG,Wang S,Tan J,Gerbault P,Wark A,Tan L,Yang Y,Li S,Tang K,Chen H,Powell A,Itan Y,Fuller D,Lohmueller J,Mao J,Schachar A,Paymer M,Hostetter E,Byrne E,Burnett M,McMahon AP,Thomas MG,Lieberman DE,Jin

    更新日期:2013-02-14 00:00:00

  • The membrane-spanning segment of invariant chain (I gamma) contains a potentially cleavable signal sequence.

    abstract::The human invariant chain (I gamma) of class II histocompatibility antigens spans the membrane of the endoplasmic reticulum once. It exposes a small amino-terminal domain on the cytoplasmic side and a carboxy-terminal, glycosylated domain on the exoplasmic side of the membrane. When the exoplasmic domain of I gamma is...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(86)90710-5

    authors: Lipp J,Dobberstein B

    更新日期:1986-09-26 00:00:00

  • Scrambled ribosomal RNA gene pieces in Chlamydomonas reinhardtii mitochondrial DNA.

    abstract::We describe here a bizarre organization of the single large subunit (LSU) and small subunit (SSU) rRNA genes in the mitochondrial DNA of Chlamydomonas reinhardtii. Each gene is discontinuous, with gene pieces encoding specific rRNA domains ("modules") interspersed with one another and with intact protein coding and tR...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(88)90026-8

    authors: Boer PH,Gray MW

    更新日期:1988-11-04 00:00:00

  • Controlling Visually Guided Behavior by Holographic Recalling of Cortical Ensembles.

    abstract::Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether ensembles play a functional role in behavior. Some ensemble neurons have pattern completion properties, triggering the entire ensemble when activated. Using two-photon holographic optogenetics in mouse primary visual cortex, we ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2019.05.045

    authors: Carrillo-Reid L,Han S,Yang W,Akrouh A,Yuste R

    更新日期:2019-07-11 00:00:00

  • Endosome-specific localization and function of the ARF activator GNOM.

    abstract::ARF GTPases act at multiple steps of the secretory and vacuolar/lysosomal trafficking pathways, but little is known about the spatial regulation of ARF activation. In this issue of Cell, Geldner et al. demonstrate that the Arabidopsis ARF activator GNOM localizes to endosomes where it controls the polarized traffickin...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/s0092-8674(03)00038-2

    authors: Bonifacino JS,Jackson CL

    更新日期:2003-01-24 00:00:00

  • The protein network of HIV budding.

    abstract::HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the class E proteins) also participate in HIV release, we identified 22 candidate human class E proteins. These proteins were connected ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(03)00714-1

    authors: von Schwedler UK,Stuchell M,Müller B,Ward DM,Chung HY,Morita E,Wang HE,Davis T,He GP,Cimbora DM,Scott A,Kräusslich HG,Kaplan J,Morham SG,Sundquist WI

    更新日期:2003-09-19 00:00:00

  • Doubling Down on Mutant RAS Can MEK or Break Leukemia.

    abstract::Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive bi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2017.02.013

    authors: Tothova Z,Ebert BL

    更新日期:2017-02-23 00:00:00

  • Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA.

    abstract::Proliferating cell nuclear antigen (PCNA) is a cell cycle and growth regulated protein required for replication of SV40 DNA in vitro. Its function was investigated by comparison of the replication products synthesized in its presence or absence. In the completely reconstituted replication system that contains PCNA, DN...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(88)90493-x

    authors: Prelich G,Stillman B

    更新日期:1988-04-08 00:00:00

  • A DNA-dependent protease involved in DNA-protein crosslink repair.

    abstract::Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are particularly caused by endogenously produced reactive compounds such as formaldehyde, and also occur during compromised topoisomerase action. Although nucleotide excision repair and homologous recombination contribute to cell survival ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2014.04.053

    authors: Stingele J,Schwarz MS,Bloemeke N,Wolf PG,Jentsch S

    更新日期:2014-07-17 00:00:00

  • Breast cancer stem cells: eradication by differentiation therapy?

    abstract::During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2009.08.007

    authors: Beug H

    更新日期:2009-08-21 00:00:00

  • Mouse development and cell proliferation in the absence of D-cyclins.

    abstract::D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse development and in proliferation by generating mice lacking all D-cyclins. We found that these cyclin D1(-/-)D2(-/-)D3(-/-) mice develop u...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2004.07.025

    authors: Kozar K,Ciemerych MA,Rebel VI,Shigematsu H,Zagozdzon A,Sicinska E,Geng Y,Yu Q,Bhattacharya S,Bronson RT,Akashi K,Sicinski P

    更新日期:2004-08-20 00:00:00

  • Autocrine beta-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation.

    abstract::Different hematopoietic cells produce minute amounts of beta-related interferon (IFN) following induction of differentiation by chemical or natural inducers. The endogenous IFN binds to type I cell surface receptors and modulates gene expression in the producer cells. We show that self-induction of two members of the ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(86)90857-3

    authors: Resnitzky D,Yarden A,Zipori D,Kimchi A

    更新日期:1986-07-04 00:00:00

  • SnapShot: Nucleo-cytoskeletal Interactions.

    abstract::The nucleus is connected to the cytoskeleton, and these connections are involved in multiple functions such as nuclear positioning, shape and stiffness, cytoskeleton organization, mechanotransduction, gene expression, chromosome positioning, DNA repair, and cell migration. ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2017.05.014

    authors: Janota CS,Calero-Cuenca FJ,Costa J,Gomes ER

    更新日期:2017-05-18 00:00:00

  • Epigenetics drives RAGs to recombination riches.

    abstract::V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2010.04.014

    authors: Schlissel MS

    更新日期:2010-04-30 00:00:00

  • Structural changes enable start codon recognition by the eukaryotic translation initiation complex.

    abstract::During eukaryotic translation initiation, initiator tRNA does not insert fully into the P decoding site on the 40S ribosomal subunit. This conformation (POUT) is compatible with scanning mRNA for the AUG start codon. Base pairing with AUG is thought to promote isomerization to a more stable conformation (PIN) that arr...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2014.10.001

    authors: Hussain T,Llácer JL,Fernández IS,Munoz A,Martin-Marcos P,Savva CG,Lorsch JR,Hinnebusch AG,Ramakrishnan V

    更新日期:2014-10-23 00:00:00

  • Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.

    abstract::The 2.6 Angstrom crystal structure for human cyclin-dependent kinase 2(CDK2) in complex with CksHs1, a human homolog of essential yeast cell cycle-regulatory proteins suc1 and Cks1, reveals that CksHs1 binds via all four beta strands to the kinase C-terminal lobe. This interface is biologically critical, based upon mu...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81065-x

    authors: Bourne Y,Watson MH,Hickey MJ,Holmes W,Rocque W,Reed SI,Tainer JA

    更新日期:1996-03-22 00:00:00

  • Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins.

    abstract::Vanadate has been shown to inhibit phosphatases that remove phosphate groups from phosphotyrosine in cell-free systems. Addition of vanadate to the culture medium of NRK-1 cells resulted in a maximal 40-fold increase in the level of phosphotyrosine in cell protein. Also, vanadate induced transformation as evidenced by...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(85)80051-9

    authors: Klarlund JK

    更新日期:1985-07-01 00:00:00

  • Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

    abstract::A complex interplay of environmental factors impacts the metabolism of human cells, but neither traditional culture media nor mouse plasma mimic the metabolite composition of human plasma. Here, we developed a culture medium with polar metabolite concentrations comparable to those of human plasma (human plasma-like me...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2017.03.023

    authors: Cantor JR,Abu-Remaileh M,Kanarek N,Freinkman E,Gao X,Louissaint A Jr,Lewis CA,Sabatini DM

    更新日期:2017-04-06 00:00:00

  • The many faces of PPARgamma.

    abstract::In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular disease, the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) has emerged as a transcriptional regulator of metabolism whose activity can be modulated by direct binding of small molecules. As the master ...

    journal_title:Cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.cell.2005.11.026

    authors: Lehrke M,Lazar MA

    更新日期:2005-12-16 00:00:00

  • Intron sequences involved in lariat formation during pre-mRNA splicing.

    abstract::We have shown that lariat formation during in vitro splicing of several RNA precursors, from Drosophila to man, occurs at a unique and identifiable but weakly conserved site, 18 to 37 nucleotides proximal to the 3' splice site. Lariat formation within an artificial intron lacking a normal branch-point sequence occurs ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(85)90064-9

    authors: Reed R,Maniatis T

    更新日期:1985-05-01 00:00:00

  • Chicken myeloid stem cells infected by retroviruses carrying the v-fps oncogene do not require exogenous growth factors to differentiate in vitro.

    abstract::To determine the function of c-fps in chicken macrophages and granulocytic cells we have infected chicken bone marrow cells with retroviruses containing the v-fps oncogene. Normal chicken macrophage progenitors, M-CFCs, give rise to macrophage colonies in semisolid cultures when macrophage colony stimulating factor (M...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(86)90494-0

    authors: Carmier JF,Samarut J

    更新日期:1986-01-17 00:00:00

  • A Smad transcriptional corepressor.

    abstract::Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)80712-6

    authors: Wotton D,Lo RS,Lee S,Massagué J

    更新日期:1999-04-02 00:00:00

  • TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective.

    abstract::T cells detect infection of cells by recognizing peptide fragments of foreign proteins bound to class I molecules of the major histocompatibility complex (MHC) on the surface of the infected cell. MHC class I molecules bind peptide in the endoplasmic reticulum, and analysis of mutant cells has demonstrated that an ade...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(93)80058-m

    authors: Shepherd JC,Schumacher TN,Ashton-Rickardt PG,Imaeda S,Ploegh HL,Janeway CA Jr,Tonegawa S

    更新日期:1993-08-13 00:00:00

  • Presence of histone H1 on an active Balbiani ring gene.

    abstract::We have investigated whether histone H1 is present on active Balbiani ring genes in the salivary glands of Chironomus tentans using immunoelectron microscopy. The genes were studied in two activity states: maximally activated genes with a fully extended template and repressed genes in a 30 nm fiber conformation. Histo...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(90)90717-s

    authors: Ericsson C,Grossbach U,Björkroth B,Daneholt B

    更新日期:1990-01-12 00:00:00

  • Temperature-sensitive mutants of avian erythroblastosis virus: surface expression of the erbB product correlates with transformation.

    abstract::The v-erbB gene of avian erythroblastosis virus (AEV) codes for an integral plasma membrane glycoprotein, gp74erbB. Expression of gp74erbB and its intracellular precursors, gp66erbB and gp68erbB, has been studied in cells transformed by two temperature-sensitive mutants of AEV. After shift to 42 degrees C, the process...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(84)90046-1

    authors: Beug H,Hayman MJ

    更新日期:1984-04-01 00:00:00

  • Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy.

    abstract::Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important drivers of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer mo...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2020.11.018

    authors: Rehman SK,Haynes J,Collignon E,Brown KR,Wang Y,Nixon AML,Bruce JP,Wintersinger JA,Singh Mer A,Lo EBL,Leung C,Lima-Fernandes E,Pedley NM,Soares F,McGibbon S,He HH,Pollet A,Pugh TJ,Haibe-Kains B,Morris Q,Ramalho-San

    更新日期:2021-01-07 00:00:00