Abstract:
:The interplay of genetics and the environment in the etiology of Alzheimer's disease (AD) is not well understood. Now, Lazarov and coworkers show that a simple paradigm of environmental enrichment alleviates amyloid burden and alters disease-associated gene expression changes in a double transgenic mouse model of AD.
journal_name
Celljournal_title
Cellauthors
Karsten SL,Geschwind DHdoi
10.1016/j.cell.2005.02.027subject
Has Abstractpub_date
2005-03-11 00:00:00pages
572-4issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(05)00194-7journal_volume
120pub_type
评论,杂志文章,评审相关文献
CELL文献大全abstract::Previous work from our laboratory has demonstrated that a subclass of the aminoglycoside antibiotics, those containing the drug fragment paromamine, stimulates mistranslation in cell-free protein-synthesizing systems derived from eucaryotic cells. We report here experiments which show that the ciliate Tetrahymena ther...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(78)90201-5
更新日期:1978-02-01 00:00:00
abstract::Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured mammospheres, on the basis of their ability to retain the lipophilic dye PKH26 as a consequence of their quiescent nature. PKH26-positive cells po...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.12.007
更新日期:2010-01-08 00:00:00
abstract::Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a mo...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.12.045
更新日期:2016-01-14 00:00:00
abstract::Transcriptional analysis of SV40 late promoter mutants indicates that the DNA sequence 5'-GGTACCTAACC-3' (map positions 294-304) is important in the control of SV40 late RNA expression. C to T base substitutions at map positions 298, 299 and 304 increased initiation of late RNA synthesis at map position 325 five to te...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90318-x
更新日期:1982-12-01 00:00:00
abstract::Most inducible transcriptional programs consist of primary and secondary response genes (PRGs and SRGs) that differ in their kinetics of expression and in their requirements for new protein synthesis and chromatin remodeling. Here we show that many PRGs, in contrast to SRGs, have preassembled RNA polymerase II (Pol II...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.05.047
更新日期:2009-07-10 00:00:00
abstract::Receptor dimerization is ubiquitous to the action of all receptor tyrosine kinases, and in the case of dimeric ligands, such as the stem cell factor (SCF), it was attributed to ligand bivalency. However, by using a dimerization-inhibitory monoclonal antibody to the SCF receptor, we confined a putative dimerization sit...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90455-7
更新日期:1995-01-13 00:00:00
abstract::Retrograde transport, in which proteins and lipids are shuttled between endosomes and biosynthetic/secretory compartments such as the Golgi apparatus, is crucial for a diverse range of cellular functions. Mechanistic studies that explore the molecular machinery involved in this retrograde trafficking route are sheddin...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2008.12.009
更新日期:2008-12-26 00:00:00
abstract::Although current immune-checkpoint therapy (ICT) mainly targets lymphoid cells, it is associated with a broader remodeling of the tumor micro-environment. Here, using complementary forms of high-dimensional profiling, we define differences across all hematopoietic cells from syngeneic mouse tumors during unrestrained ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.09.030
更新日期:2018-11-01 00:00:00
abstract::The functional consequences of glycan structural changes associated with cellular differentiation are ill defined. Herein, we investigate the role of glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8alphabeta coreceptor to the thymocyte surface. We show that immature CD4(+)CD8(+) double-positive...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00577-3
更新日期:2001-11-16 00:00:00
abstract::p25rum1 from the fission yeast S. pombe is shown to act as a specific in vitro inhibitor of the p34cdc2/p56cdc13 mitotic kinase. It is also shown that early G1 cells contain p25rum1, which associates with and inhibits the mitotic kinase, and maintains p56cdc13 mitotic B cyclin at a low level, ensuring that these cells...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90215-5
更新日期:1995-12-15 00:00:00
abstract::We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks. Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidly developed immature T and B lymphomas and solid tumors. Moreover, H2AX haploinsufficiency caused genomic instability in normal...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00566-x
更新日期:2003-08-08 00:00:00
abstract::The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and thrombosis, but the mechanistic details underlying these processes remain to be determined. In this study, we demonstrate endothelial disrupti...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.10.005
更新日期:2020-11-25 00:00:00
abstract::A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles). Consistent with the fact that light ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81638-4
更新日期:1998-11-25 00:00:00
abstract::Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(03)01031-6
更新日期:2004-01-23 00:00:00
abstract::Minimal hammerhead ribozymes have been characterized extensively by static and time-resolved crystallography as well as numerous biochemical analyses, leading to mutually contradictory mechanistic explanations for catalysis. We present the 2.2 A resolution crystal structure of a full-length Schistosoma mansoni hammerh...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.06.036
更新日期:2006-07-28 00:00:00
abstract::In this issue of Cell, use live-fluorescence microscopy to monitor individual genomic loci as they replicate in budding yeast. They confirm that DNA is recruited to replication factories and show that sister replication forks initiated from the same origin are held together within a single replication factory. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2006.06.014
更新日期:2006-06-30 00:00:00
abstract::The effects of beta-estradiol (estrogen; a minor component of yeast cells) on S. cerevisiae cells in the G0 and G1 phases were examined. Results showed that estrogen stimulated the recovery of growth from G0 arrest induced by nutrient limitation or ts mutation of cdc35 (adenylate cyclase) in the early G1 phase, and in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90136-0
更新日期:1989-05-19 00:00:00
abstract::The ELH prohormone is proteolytically processed into at least nine peptides which govern egg-laying behavior in Aplysia. Quantitative immunocytochemistry demonstrates that peptides derived from the prohormone are packaged into distinct vesicle classes. Further experiments suggest the segregation occurs via a rapid ini...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(88)91131-2
更新日期:1988-09-09 00:00:00
abstract::Syntaxin 1A plays a central role in neurotransmitter release through multiple protein-protein interactions. We have used NMR spectroscopy to identify an autonomously folded N-terminal domain in syntaxin 1A and to elucidate its three-dimensional structure. This 120-residue N-terminal domain is conserved in plasma membr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81742-0
更新日期:1998-09-18 00:00:00
abstract::In the ciliated protozoan Paramecium tetraurelia, Piwi-associated small RNAs are generated upon the elimination of tens of thousands of short transposon-derived DNA segments as part of development. These RNAs then target complementary DNA for elimination in a positive feedback process, contributing to germline defense...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.02.020
更新日期:2017-03-09 00:00:00
abstract::Radioactive alpha factor is degraded to discrete biologically inactive fragments by the target a cells of S. cerevisiae, but not by alpha cells which make the pheromone. The pattern of cleavage products and sequence analysis of one fragment indicated that the first scission occurred between leucine 6 and lysine 7. The...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90117-x
更新日期:1979-11-01 00:00:00
abstract::Activation of plasma membrane calcium channels by depletion of endoplasmic reticulum (ER) calcium stores is important for calcium entry in many cell types. Park et al. (2009) now show that direct binding of the ER protein STIM to tetramers of the Orai1 calcium channel in the plasma membrane triggers opening of this ch...
journal_title:Cell
pub_type: 评论,社论
doi:10.1016/j.cell.2009.02.022
更新日期:2009-03-06 00:00:00
abstract::A large (approximately 200 kd) subunit of cellular RNA polymerase II (Pol II) and a virus-encoded subunit of rabbit poxvirus (RPV) RNA polymerase (137 kd) react with common monoclonal antibodies. Hybridization studies with viral and cellular DNA clones confirm that the viral and cellular proteins are related. Followin...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90268-0
更新日期:1986-02-28 00:00:00
abstract::We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(85)80132-x
更新日期:1985-08-01 00:00:00
abstract::Mature HIV-1 particles contain conical-shaped capsids that enclose the viral RNA genome and perform essential functions in the virus life cycle. Previous structural analysis of two- and three-dimensional arrays of the capsid protein (CA) hexamer revealed three interfaces. Here, we present a cryoEM study of a tubular a...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.10.010
更新日期:2009-11-13 00:00:00
abstract::We have tested the hypothesis that DNA methylation patterns are replicated in the somatic cells of vertebrates. Using M-Hpa II, the modification enzyme from Haemophilus parainfluenzae which methylates the internal cytosine residues in the sequence 5'CCGG 3' GGCC, we methylated bacteriophage phi X174 RF DNA and the clo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90498-0
更新日期:1981-04-01 00:00:00
abstract::Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and h...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.12.009
更新日期:2014-12-18 00:00:00
abstract::We present an integrated analysis of the clinical measurements, immune cells, and plasma multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial blood draws collected during the first week of infection following diagnosis. We identify a major shift between mild and moderate diseas...
journal_title:Cell
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.cell.2020.10.037
更新日期:2020-12-10 00:00:00
abstract::Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing di...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.06.043
更新日期:2016-07-28 00:00:00
abstract::Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tiss...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.12.021
更新日期:2015-01-15 00:00:00