Tracing the retrograde route in protein trafficking.

abstract：:The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear, which unde...

journal_title：Cell

authors： Karavani E,Zuk O,Zeevi D,Barzilai N,Stefanis NC,Hatzimanolis A,Smyrnis N,Avramopoulos D,Kruglyak L,Atzmon G,Lam M,Lencz T,Carmi S

更新日期：2019-11-27 00:00:00

abstract：:How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after vi...

journal_title：Cell

authors： Kaech SM,Hemby S,Kersh E,Ahmed R

更新日期：2002-12-13 00:00:00

abstract：:The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle arrest, apoptosis, and the maintenance of genome stability. We have identified a p53-inducible gene named TIGAR (TP53-induced glycolysis and apoptosis regulator). TIGAR expression lowered fruc...

journal_title：Cell

authors： Bensaad K,Tsuruta A,Selak MA,Vidal MN,Nakano K,Bartrons R,Gottlieb E,Vousden KH

更新日期：2006-07-14 00:00:00

abstract：:The kinetics of association of epidermal growth factor (EGF) and diferric-transferrin (TF) with clathrin-coated membranes of KB cells were examined using anti-clathrin antibody bound to Staphylococcus aureus. The ligands were bound to cells at 4 degrees C and after warming to 30 degrees C for 5 min, both ligands were ...

journal_title：Cell

authors： Hanover JA,Willingham MC,Pastan I

更新日期：1984-12-01 00:00:00

abstract：:The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally associates with a cohort of highly conserved cofactors to form a macromolecular complex that includes menin, a product of the MEN1 tumor suppressor ...

journal_title：Cell

authors： Yokoyama A,Somervaille TC,Smith KS,Rozenblatt-Rosen O,Meyerson M,Cleary ML

更新日期：2005-10-21 00:00:00

abstract：:Multiple proteins act co-operatively in mammalian clathrin-mediated endocytosis (CME) to generate endocytic vesicles from the plasma membrane. The principles controlling the activation and organization of the actin cytoskeleton during mammalian CME are, however, not fully understood. Here, we show that the protein FCH...

journal_title：Cell

authors： Almeida-Souza L,Frank RAW,García-Nafría J,Colussi A,Gunawardana N,Johnson CM,Yu M,Howard G,Andrews B,Vallis Y,McMahon HT

更新日期：2018-07-12 00:00:00

abstract：:To determine the structural features responsible for the curvature of kinetoplast DNA, we studied 13 adenine tracts in Crithidia fasciculata kinetoplast DNA. The structures of the A tracts were analyzed by cutting the DNA with hydroxyl radical. Reactivity of hydroxyl radical toward the DNA backbone progressively decre...

journal_title：Cell

authors： Burkhoff AM,Tullius TD

更新日期：1987-03-27 00:00:00

abstract：:We present the first isolation of the terminal DNA of an intact Drosophila telomere. It differs from those isolated from other eukaryotes by the lack of short tandem repeats at the terminus. The terminal 14.5 kb is composed of four tandem elements derived from two families of non-long terminal repeat retrotransposons ...

journal_title：Cell

authors： Levis RW,Ganesan R,Houtchens K,Tolar LA,Sheen FM

更新日期：1993-12-17 00:00:00

abstract：:Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role for Ras-Erk-ETS signaling in aging in Drosophila. We show that inhibition of Ras is sufficient for lifespan extension downstream of reduced...

journal_title：Cell

authors： Slack C,Alic N,Foley A,Cabecinha M,Hoddinott MP,Partridge L

更新日期：2015-07-02 00:00:00

abstract：:Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then f...

journal_title：Cell

authors： Barasch J,Yang J,Ware CB,Taga T,Yoshida K,Erdjument-Bromage H,Tempst P,Parravicini E,Malach S,Aranoff T,Oliver JA

更新日期：1999-11-12 00:00:00

abstract：:Treatment of guinea pig neutrophils with pertussis toxin (islet-activating protein; IAP) results in inhibition of N-formyl peptide receptor-mediated release of arachidonic acid and granular enzymes. Inhibition by the toxin is specific, in that responses to the calcium ionophore A23187 are not affected. The action of t...

journal_title：Cell

authors： Bokoch GM,Gilman AG

更新日期：1984-12-01 00:00:00

abstract：:The scrapie (PrPSc) and cellular (PrPC) prion proteins are encoded by the same gene, and their different properties are thought to arise from posttranslational modifications. We have found a phosphatidylinositol glycolipid on both PrPC and PrP 27-30 (derived from PrPSc by limited proteolysis at the amino terminus). Et...

journal_title：Cell

authors： Stahl N,Borchelt DR,Hsiao K,Prusiner SB

更新日期：1987-10-23 00:00:00

abstract：:Antisense Piwi-interacting RNAs (piRNAs) guide silencing of established transposons during germline development, and sense piRNAs drive ping-pong amplification of the antisense pool, but how the germline responds to genome invasion is not understood. The KoRV-A gammaretrovirus infects the soma and germline and is swee...

journal_title：Cell

authors： Yu T,Koppetsch BS,Pagliarani S,Johnston S,Silverstein NJ,Luban J,Chappell K,Weng Z,Theurkauf WE

更新日期：2019-10-17 00:00:00

abstract：:The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show he...

journal_title：Cell

authors： Lee JJ,von Kessler DP,Parks S,Beachy PA

更新日期：1992-10-02 00:00:00

abstract：:Following EMS mutagenesis we recovered a mutant of D. melanogaster that grows at concentrations of alpha-amanitin lethal to wild-type. To our knowledge this mutant represents the first example of an amanitin-resistant eucaryotic organism. The amanitin resistance of the mutant (AmaC4) is due to an alteration in its DNA...

journal_title：Cell

authors： Greenleaf AL,Borsett LM,Jiamachello PF,Coulter DE

更新日期：1979-11-01 00:00:00

abstract：:Human autoantibodies that recognize the spindle poles of mammals, plants, and insects were found to recognize two antigens in yeast. One of these proteins, called SPA1 (for Spindle Pole Antigen), is antigenically related to the spindle poles of a diverse set of organisms. The gene encoding SPA1 was cloned by immunoscr...

journal_title：Cell

authors： Snyder M,Davis RW

更新日期：1988-09-09 00:00:00

abstract：:During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. H...

journal_title：Cell

authors： Linneweber GA,Jacobson J,Busch KE,Hudry B,Christov CP,Dormann D,Yuan M,Otani T,Knust E,de Bono M,Miguel-Aliaga I

更新日期：2014-01-16 00:00:00

abstract：:M-MuLV-specific DNA probes were used to establish the state of integration and amplification of recombinant proviral sequences in Moloney virus-induced tumors of Balb/Mo, Balb/c and 129 mice. The somatically acquired viral sequences contain both authentic M-MuLV genomes and recombinants of M-MuLV with endogenous viral...

journal_title：Cell

authors： van der Putten H,Quint W,van Raaij J,Maandag ER,Verma IM,Berns A

更新日期：1981-06-01 00:00:00

abstract：:The structure of the complex formed by the arginine-rich motif of the transcriptional antitermination protein N of phage lambda and boxB RNA was determined by heteronuclear magnetic resonance spectroscopy. A bent alpha helix in N recognizes primarily the shape and negatively charged surface of the boxB hairpin through...

journal_title：Cell

authors： Legault P,Li J,Mogridge J,Kay LE,Greenblatt J

更新日期：1998-04-17 00:00:00

abstract：:Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at...

journal_title：Cell

authors： Chan SK,Struhl G

更新日期：2002-10-18 00:00:00

abstract：:The structure of the initiator binding protein from the primitive eukaryote Trichomonas vaginalis reveals how a single protein can orchestrate promoter recognition, RNA polymerase II recruitment, and start site selection, and provides an evolutionary link with transcription initiation in higher eukaryotes. ...

journal_title：Cell

authors： Marmorstein R

更新日期：2003-11-14 00:00:00

abstract：:We have isolated two adenylyl cyclase genes, designated ACA and ACG, from Dictyostelium. The proposed structure for ACA resembles that proposed for mammalian adenylyl cyclases: two large hydrophilic domains and two sets of six transmembrane spans. ACG has a novel structure, reminiscent of the membrane-bound guanylyl c...

journal_title：Cell

authors： Pitt GS,Milona N,Borleis J,Lin KC,Reed RR,Devreotes PN

更新日期：1992-04-17 00:00:00

abstract：:Rare diseases are powerful windows into biological processes and can serve as models for the development of therapeutic strategies. The progress made on the premature aging disorder Progeria is a shining example of the impact that studies of rare diseases can have. ...

journal_title：Cell

authors： Gordon LB,Rothman FG,López-Otín C,Misteli T

更新日期：2014-01-30 00:00:00

abstract：:Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses' silencing machinery of embryonic stem cells to stably silence three highly expressed genes in somatic cells by epigenetics. This was achieved by transiently expres...

journal_title：Cell

authors： Amabile A,Migliara A,Capasso P,Biffi M,Cittaro D,Naldini L,Lombardo A

更新日期：2016-09-22 00:00:00

abstract：:Long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding was observed from the upper respiratory tract of a female immunocompromised individual with chronic lymphocytic leukemia and acquired hypogammaglobulinemia. Shedding of infectious SARS-CoV-2 was observed up to 70 days, and of genomic and s...

journal_title：Cell

authors： Avanzato VA,Matson MJ,Seifert SN,Pryce R,Williamson BN,Anzick SL,Barbian K,Judson SD,Fischer ER,Martens C,Bowden TA,de Wit E,Riedo FX,Munster VJ

更新日期：2020-12-23 00:00:00

abstract：:The sigma factor sigma 70 of E. coli RNA polymerase acts not only in initiation, but also at an early stage of elongation to induce a transcription pause, and simultaneously to allow the phage lambda gene Q transcription antiterminator to act. We identify the signal in DNA that induces early pausing to be a version of...

journal_title：Cell

authors： Ring BZ,Yarnell WS,Roberts JW

更新日期：1996-08-09 00:00:00

abstract：:Abiotic stress, such as salinity, drought, and cold, causes detrimental yield losses for all major plant crop species. Understanding mechanisms that improve plants' ability to produce biomass, which largely is constituted by the plant cell wall, is therefore of upmost importance for agricultural activities. Cellulose ...

journal_title：Cell

authors： Endler A,Kesten C,Schneider R,Zhang Y,Ivakov A,Froehlich A,Funke N,Persson S

更新日期：2015-09-10 00:00:00

abstract：:The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins. ...

journal_title：Cell

authors： Zhang YZ,Holmes EC

更新日期：2020-04-16 00:00:00

abstract：:Mutations in four nuclear genes, kar1 cdc4, 28, and 37, block or impair nuclear fusion during conjugation of Saccharomyces cerevisiae. Mutations in all four genes are recessive for the caryogamy defect; in matings between diploid cells both of which are heterozygous for any one of the four mutations (-/+ X -/+), caryo...

journal_title：Cell

authors： Dutcher SK,Hartwell LH

更新日期：1983-05-01 00:00:00

abstract：:Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the...

journal_title：Cell

authors： Salmena L,Poliseno L,Tay Y,Kats L,Pandolfi PP

更新日期：2011-08-05 00:00:00