Abstract:
:Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse model of multiple sclerosis.
journal_name
Celljournal_title
Cellauthors
Osso LA,Chan JRdoi
10.1016/j.cell.2015.12.001subject
Has Abstractpub_date
2015-12-17 00:00:00pages
1574-6issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(15)01625-6journal_volume
163pub_type
评论,杂志文章相关文献
CELL文献大全abstract::Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protei...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.040
更新日期:2014-05-08 00:00:00
abstract::Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.04.008
更新日期:2014-04-24 00:00:00
abstract::Eukaryotic cells have developed mechanisms for regulating the nuclear transport of macromolecules that control various cellular events including movement through defined stages of the cell cycle. In yeast cells, where the nuclear envelope remains intact throughout the cell cycle, these transport regulatory mechanisms ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00986-3
更新日期:2003-12-26 00:00:00
abstract::The scrapie (PrPSc) and cellular (PrPC) prion proteins are encoded by the same gene, and their different properties are thought to arise from posttranslational modifications. We have found a phosphatidylinositol glycolipid on both PrPC and PrP 27-30 (derived from PrPSc by limited proteolysis at the amino terminus). Et...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90150-4
更新日期:1987-10-23 00:00:00
abstract::To search for histone domains that may regulate transcription in vivo, we made deletions and amino acid substitutions in the histone N-termini of S. cerevisiae. Histone H4 N-terminal residues 4-23, which include the extremely conserved, reversibly acetylated lysines (at positions 5, 8, 12, and 16), were found to encom...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90554-c
更新日期:1991-06-14 00:00:00
abstract::ETS transcription factors ETV2, FLI1, and ERG1 specify pluripotent stem cells into induced vascular endothelial cells (iVECs). However, iVECs are unstable and drift toward nonvascular cells. We show that human midgestation c-Kit(-) lineage-committed amniotic cells (ACs) can be reprogrammed into vascular endothelial ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.09.032
更新日期:2012-10-26 00:00:00
abstract::The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap and bring the promise of healthy l...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.02.026
更新日期:2015-02-26 00:00:00
abstract::Nuclear exclusion of the forkhead transcription factor FOXO3a by protein kinase Akt contributes to cell survival. We investigated the pathological relationship between phosphoylated-Akt (Akt-p) and FOXO3a in primary tumors. Surprisingly, FOXO3a was found to be excluded from the nuclei of some tumors lacking Akt-p, sug...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(04)00302-2
更新日期:2004-04-16 00:00:00
abstract::Designing successful microbiota-based therapies requires in-depth understanding of the ecological foundations of this community. In this issue, two studies by Whitaker et al. and Lim et al. provide refined genetic tools for dissecting the spatial organization and temporal dynamics of bacterial communities at the singl...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.04.009
更新日期:2017-04-20 00:00:00
abstract::The kinetics of association of epidermal growth factor (EGF) and diferric-transferrin (TF) with clathrin-coated membranes of KB cells were examined using anti-clathrin antibody bound to Staphylococcus aureus. The ligands were bound to cells at 4 degrees C and after warming to 30 degrees C for 5 min, both ligands were ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90006-0
更新日期:1984-12-01 00:00:00
abstract::Thrombin stimulates 32Pi incorporation into phosphatidylinositol 4-phosphate (PIP), phosphatidylinositol 4,5-bis-phosphate (PIP2), and phosphatidylinositol (PI), and initiates DNA synthesis in hamster (NIL) fibroblasts at a half-maximal concentration of 125 ng/ml. Neomycin, which binds PIP2 and PIP, inhibits both thro...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90105-9
更新日期:1985-09-01 00:00:00
abstract::The 5' terminal structure of the mRNA synthesized in vitro by the virion-associated RNA polymerase of vesicular stomatitis virus in the presence of S-adenosyl-L-methione consists of 7-methyl guanosine linked to 2'-O-methyl adenosine through a 5'-5' pyrophosphate bond as m7G(5')ppp(5')A-m-p ... The alpha and beta phosp...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90091-4
更新日期:1975-05-01 00:00:00
abstract::Serum response factor (SRF) forms a ternary complex at the c-fos serum response element (SRE) with an accessory factor, Elk-1. We constructed altered-binding specificity derivatives of SRF and Elk-1 that form a ternary complex at a mutated, inactive SRE; like Elk-1, the Elk-1 variant only binds its target as part of a...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90238-l
更新日期:1993-04-23 00:00:00
abstract::After translational termination, mRNA and P site deacylated tRNA remain associated with ribosomes in posttermination complexes (post-TCs), which must therefore be recycled by releasing mRNA and deacylated tRNA and by dissociating ribosomes into subunits. Recycling of bacterial post-TCs requires elongation factor EF-G ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.08.041
更新日期:2007-10-19 00:00:00
abstract::The structure of chicken erythrocyte and chicken liver chromatin has been studied by enzymatic digestion with micrococcal nuclease and DNAase I. Comparison of the fragments produced by brief digestion with micrococcal nuclease indicates that chicken erythrocyte chromatin has a longer nucleosome repeat than chicken liv...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(76)90045-3
更新日期:1976-12-01 00:00:00
abstract::To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We ide...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.07.009
更新日期:2012-08-03 00:00:00
abstract::The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined. The terminus of each genome exists as a Y-shaped hairpin structure involving 115 or 116 nucleotides. The sequence of this region of DNA is highly conserved and shows no evidence of internal sequence het...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90276-9
更新日期:1979-07-01 00:00:00
abstract::A 1.1 kb intron containing an open reading frame (ORF) in one allele (omega+) of the yeast mitochondrial 21S rRNA gene is nearly quantitatively inserted in crosses into a 21S rRNA allele lacking that intron (omega-). We have determined that this nonreciprocal exchange initiates soon after cells fuse to form zygotes an...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90348-4
更新日期:1985-04-01 00:00:00
abstract::Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomen...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2019.01.043
更新日期:2019-02-21 00:00:00
abstract::We have tested a model for global ribosome biosynthesis by examining the effects of increased gene dosage on the synthesis of rRNA. Increasing gene dosage does not lead to a significant increase in total rRNA transcription; i.e., rRNA synthesis from individual rRNA operons is reduced to keep total rRNA production unch...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90029-6
更新日期:1983-07-01 00:00:00
abstract::The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Dros...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90574-0
更新日期:1988-05-20 00:00:00
abstract::Nutrition presents unanswered scientific questions of high public health importance. We envision model systems composed of interacting gastrointestinal and metabolic tissues derived from human embryonic stem cells, populated by gut microbiota. The culture will be embedded in 3D scaffolds, creating a controlled experim...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.02.039
更新日期:2015-03-26 00:00:00
abstract::GAL4 derivatives containing an activation domain alleviated repression of a promoter during nucleosome assembly. A GAL4 derivative lacking an activation domain stably bound the promoter during nucleosome assembly but was not sufficient to preserve promoter function. The activation domain of GAL4 derivatives was essent...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90237-s
更新日期:1991-02-08 00:00:00
abstract::Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role for Ras-Erk-ETS signaling in aging in Drosophila. We show that inhibition of Ras is sufficient for lifespan extension downstream of reduced...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.06.023
更新日期:2015-07-02 00:00:00
abstract::Microbial populations can maximize fitness in dynamic environments through bet hedging, a process wherein a subpopulation assumes a phenotype not optimally adapted to the present environment but well adapted to an environment likely to be encountered. Here, we show that oxygen induces fluctuating expression of the tri...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.005
更新日期:2018-03-22 00:00:00
abstract::Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic functions with circa...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.04.020
更新日期:2013-05-09 00:00:00
abstract::NRK fibroblasts exposed to transforming growth factor-beta (TGF-beta) show increased binding of radiolabeled epidermal growth factor (EGF) relative to untreated cells. The binding of another growth factor, rat insulin-like growth factor-II, is unaffected. The increase in EGF binding induced by TGF-beta is not due to i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90071-0
更新日期:1984-01-01 00:00:00
abstract::Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have dev...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2017.09.021
更新日期:2017-10-05 00:00:00
abstract::Adult skeletal muscle generates force in a controlled and directed manner through the contraction of highly specialized, postmitotic, multinucleated myofibers. Life-long muscle function relies on maintenance and regeneration of myofibers through a highly regulated process beginning with activation of normally quiescen...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2005.08.021
更新日期:2005-09-09 00:00:00
abstract::Francis' office window (at the Salk) commanded a panorama of the Pacific. "This grand natural scene was a physical correlate of Francis's intellectual world: wide-ranging, brilliantly lit, a little overawing, but also immensely inviting and above all an exciting place to be." (Mitchison, 2004). ...
journal_title:Cell
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.cell.2016.11.008
更新日期:2016-12-01 00:00:00