Abstract：
:Recent work has identified a mouse gene (tsg101) whose inactivation in fibroblasts results in cellular transformation and the ability to produce metastatic tumors in nude mice. Here, we report that the human homolog, TSG101, which we isolated and mapped to chromosome 11, bands 15.1-15.2, a region proposed to contain tumor suppressor gene(s), is mutated at high frequency in human breast cancer. In 7 of 15 uncultured primary human breast carcinomas, intragenic deletions were shown in TSG101 genomic DNA and transcripts by gel and sequence analysis, and mutations affecting two TSG101 alleles were identified in four of these cancers. No TSG101 defects were found in matched normal breast tissue from the breast cancer patients. These findings strongly implicate TSG101 mutations in human breast cancer.
journal_name
Celljournal_title
Cellauthors
Li L,Li X,Francke U,Cohen SNdoi
10.1016/s0092-8674(00)81866-8subject
Has Abstractpub_date
1997-01-10 00:00:00pages
143-54issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81866-8journal_volume
88pub_type
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