Abstract：
:One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid homeostasis (glycine, serine, and methionine), epigenetic maintenance, and redox defense. Both within eukaryotic cells and across organs, 1C metabolic reactions are compartmentalized. Here we review the fundamentals of mammalian 1C metabolism, including the pathways active in different compartments, cell types, and biological states. Emphasis is given to recent discoveries enabled by modern genetics, analytical chemistry, and isotope tracing. An emerging theme is the biological importance of mitochondrial 1C reactions, both for producing 1C units that are exported to the cytosol and for making additional products, including glycine and NADPH. Increased clarity regarding differential folate pathway usage in cancer, stem cells, development, and adult physiology is reviewed and highlights new opportunities for selective therapeutic intervention.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Ducker GS,Rabinowitz JDdoi
10.1016/j.cmet.2016.08.009subject
Has Abstractpub_date
2017-01-10 00:00:00pages
27-42issue
1eissn
1550-4131issn
1932-7420pii
S1550-4131(16)30425-9journal_volume
25pub_type
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