Abstract：
:Oxidative stress causes mitochondrial dysfunction and metabolic complications through unknown mechanisms. Cardiolipin (CL) is a key mitochondrial phospholipid required for oxidative phosphorylation. Oxidative damage to CL from pathological remodeling is implicated in the etiology of mitochondrial dysfunction commonly associated with diabetes, obesity, and other metabolic diseases. Here, we show that ALCAT1, a lyso-CL acyltransferase upregulated by oxidative stress and diet-induced obesity (DIO), catalyzes the synthesis of CL species that are highly sensitive to oxidative damage, leading to mitochondrial dysfunction, ROS production, and insulin resistance. These metabolic disorders were reminiscent of those observed in type 2 diabetes and were reversed by rosiglitazone treatment. Consequently, ALCAT1 deficiency prevented the onset of DIO and significantly improved mitochondrial complex I activity, lipid oxidation, and insulin signaling in ALCAT1(-/-) mice. Collectively, these findings identify a key role of ALCAT1 in regulating CL remodeling, mitochondrial dysfunction, and susceptibility to DIO.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Li J,Romestaing C,Han X,Li Y,Hao X,Wu Y,Sun C,Liu X,Jefferson LS,Xiong J,Lanoue KF,Chang Z,Lynch CJ,Wang H,Shi Ydoi
10.1016/j.cmet.2010.07.003subject
Has Abstractpub_date
2010-08-04 00:00:00pages
154-65issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(10)00235-4journal_volume
12pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract：:Incretin hormones exert pleiotropic metabolic actions beyond the pancreas. Although the heart expresses both incretin receptors, the cardiac biology of GIP receptor (GIPR) action remains incompletely understood. Here we show that GIPR agonism did not impair the response to cardiac ischemia. In contrast, genetic elimin...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.11.003
更新日期：2018-02-06 00:00:00
abstract：:Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are not completely understood. We demonstrate that TNFalpha signaling through TNF receptor (TNFR) 1 suppresses AMPK activity via transcriptional upregulation o...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.11.005
更新日期：2006-12-01 00:00:00
abstract：:Genome-wide association studies (GWAS) have identified multiple chronic kidney disease (CKD)-associated single-nucleotide polymorphisms (SNPs) mainly localized to non-coding genomic regions. To understand which genes and which cell types are affected by these genetic variants, compartment-specific transcriptome, genom...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2018.12.009
更新日期：2019-01-08 00:00:00
abstract：:Injection of the peptide hormone ghrelin stimulates food intake in mice and humans. However, mice born without ghrelin demonstrate no significant loss of appetite. This paradox suggests either that compensation develops in mice born without ghrelin or that ghrelin is not essential for appetite control. To distinguish ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.04.007
更新日期：2014-07-01 00:00:00
abstract：:Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containin...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2015.04.023
更新日期：2015-05-05 00:00:00
abstract：:Mammalian organs are nourished by nutrients carried by the blood circulation. These nutrients originate from diet and internal stores, and can undergo various interconversions before their eventual use as tissue fuel. Here we develop isotope tracing, mass spectrometry, and mathematical analysis methods to determine th...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.07.013
更新日期：2020-10-06 00:00:00
abstract：:Macrophages infiltrate adipose tissue in obesity and are involved in the induction of inflammation, thereby contributing to the development of obesity-associated metabolic disorders. Here, we show that the macrophage-derived soluble protein AIM is endocytosed into adipocytes via CD36. Within adipocytes, AIM associates...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.04.013
更新日期：2010-06-09 00:00:00
abstract：:We caught up with some of the leading researchers in the NAD+ metabolism and signaling field as they gathered in Dublin for the 2019 FASEB Science Research Conference. Here they share their excitement from the rich history of NAD+ biology dating back over 100 years ago to a future of translation benefiting human healt...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2019.06.013
更新日期：2019-07-02 00:00:00
abstract：:High-density lipoproteins (HDLs) can inhibit inflammatory cytokine expression on innate immune cells, but sometimes they promote cytokine production as suggested in a recent article in Cell Metabolism by van der Vorst et al. (2017). Kopecky et al. point out that the origin, handling, and storage conditions of HDL prep...
journal_title：Cell metabolism
pub_type： 信件
doi：10.1016/j.cmet.2017.04.007
更新日期：2017-07-05 00:00:00
abstract：:Diabetes is a growing epidemic, and many patients depend on insulin injections to control the disease and minimize long-term complications. In a recent manuscript published in Science, Xie et al. (2016) generate insulin-producing cells from a somatic embryonic kidney cell line through minimal genetic modification capa...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2017.01.018
更新日期：2017-02-07 00:00:00
abstract：:Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging. ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2007.08.007
更新日期：2007-09-01 00:00:00
abstract：:Obesity-related morbidity and mortality are related to fat accumulation and fat distribution in humans. Two large-scale meta-analyses recently published in Nature by Shungin et al. (2015) and Locke et al. (2015) report novel genetic associations for central and overall obesity; these greatly advance our understanding ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2015.03.016
更新日期：2015-04-07 00:00:00
abstract：:In this issue of Cell Metabolism, Macdougall et al. (2018) identify two subsets of conventional dendritic cells in visceral adipose tissue and demonstrate that these subsets engage distinct adipocyte-associated signaling pathways to drive their tolerogenic phenotypes in the lean state. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2018.02.014
更新日期：2018-03-06 00:00:00
abstract：:Reducing obesity requires an elevation of energy expenditure and/or a suppression of food intake. Here we show that enhancing hepatic glycolysis reduces body weight and adiposity in obese mice. Overexpression of glucokinase or 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is used to increase hepatic glycolysis....
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2005.07.003
更新日期：2005-08-01 00:00:00
abstract：:Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a powerful technique for their functionalization. To uncover the role of the liver-specific miR-122 in the adult liver, we inhibited it in mice with a 2'-O-methoxyethyl phosphorothioate ASO. miR-12...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.01.005
更新日期：2006-02-01 00:00:00
abstract：:Glucose and hormone responsiveness of pancreatic β cells is acquired during postnatal maturation and is critical for appropriate insulin secretion. In a recent issue of Cell Metabolism, Yoshihara et al. (2016) report that estrogen-related receptor γ (ERRγ) promotes functional maturation of both mouse neonatal β cells ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2016.04.026
更新日期：2016-05-10 00:00:00
abstract：:Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key componen...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2019.10.010
更新日期：2019-11-05 00:00:00
abstract：:Humans exhibit remarkable interindividual variations in the concentration of small molecules found throughout the body, due in part to concurrent variations in each person's associated microbial communities. Recent studies have begun to uncover how microbes interface with their host during exposure to drugs, dietary c...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.07.002
更新日期：2014-11-04 00:00:00
abstract：:During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2017.03.014
更新日期：2017-04-04 00:00:00
abstract：:Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lip...
journal_title：Cell metabolism
pub_type： 信件
doi：10.1016/j.cmet.2019.05.014
更新日期：2019-07-02 00:00:00
abstract：:Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulation at the transcriptional level, much less is known about tempor...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.10.003
更新日期：2017-01-10 00:00:00
abstract：:Postprandial hypoglycemia is a disabling complication of the treatment of obesity by gastric bypass surgery. So far, no therapy exists, and the underlying mechanisms remain unclear. Here, we hypothesized that glucose-induced IL-1β leads to an exaggerated insulin response in this condition. Therefore, we conducted a pl...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.02.013
更新日期：2020-04-07 00:00:00
abstract：:Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur exclusively via the replication of existing beta cells, but clinically meaningful restoration of human beta cell mass by proliferation has never been achieved. We discovered a population of immature beta cells that is present through...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.03.017
更新日期：2017-04-04 00:00:00
abstract：:Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN prote...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.08.023
更新日期：2015-11-03 00:00:00
abstract：:Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue culture are much higher than what has been described in vivo. Here...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.09.006
更新日期：2016-11-08 00:00:00
abstract：:Reduced folate levels can cause developmental defects and megaloblastic anemia. Padmanabhan et al. (2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descend...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2013.09.016
更新日期：2013-10-01 00:00:00
abstract：:The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are required for ve...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2007.04.001
更新日期：2007-05-01 00:00:00
abstract：:Oxidants are thought to damage cells, and stem cells are viewed as particularly vulnerable to oxidative stress. Now, a new study (Morimoto et al., 2013) suggests that the self-renewal of certain stem cells may actually require reactive oxygen species (ROS). ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2013.06.007
更新日期：2013-07-02 00:00:00
abstract：:Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through wh...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2009.08.006
更新日期：2009-09-01 00:00:00
abstract：:AS160 has emerged as a key player in insulin-mediated glucose transport through controlling GLUT4 trafficking, which is thought to be regulated by insulin-stimulated phosphorylation of sites including the 14-3-3 binding phospho-Thr649 (equivalent to Thr642 in human AS160). To define physiological roles of AS160-Thr649...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.12.005
更新日期：2011-01-05 00:00:00
