Abstract：
:Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key components of the xCT-glutamate→mGluR5-2-AG→CB1R-SREBP1-FASN paracrine communication system, Choi et al. identified potential new targets for drugs for ALD.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Kisseleva T,Brenner DAdoi
10.1016/j.cmet.2019.10.010subject
Has Abstractpub_date
2019-11-05 00:00:00pages
850-852issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(19)30566-2journal_volume
30pub_type
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