Physiological and Molecular Dissection of Daily Variance in Exercise Capacity.

Abstract:

:Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity between the early and late part of their active phase. The daytime variance in mice was dependent on exercise intensity and relied on the circadian clock proteins PER1/2. High-throughput gene expression and metabolic profiling of skeletal muscle revealed metabolic pathways that are differently activated upon exercise in a daytime-dependent manner. Remarkably, we discovered that ZMP, an endogenous AMPK activator, is induced by exercise in a time-dependent manner to regulate key steps in glycolytic and fatty acid oxidation pathways and potentially enhance exercise capacity. Overall, we propose that time of day is a major modifier of exercise capacity and associated metabolic pathways.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Ezagouri S,Zwighaft Z,Sobel J,Baillieul S,Doutreleau S,Ladeuix B,Golik M,Verges S,Asher G

doi

10.1016/j.cmet.2019.03.012

subject

Has Abstract

pub_date

2019-07-02 00:00:00

pages

78-91.e4

issue

1

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(19)30141-X

journal_volume

30

pub_type

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