Abstract:
:Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity between the early and late part of their active phase. The daytime variance in mice was dependent on exercise intensity and relied on the circadian clock proteins PER1/2. High-throughput gene expression and metabolic profiling of skeletal muscle revealed metabolic pathways that are differently activated upon exercise in a daytime-dependent manner. Remarkably, we discovered that ZMP, an endogenous AMPK activator, is induced by exercise in a time-dependent manner to regulate key steps in glycolytic and fatty acid oxidation pathways and potentially enhance exercise capacity. Overall, we propose that time of day is a major modifier of exercise capacity and associated metabolic pathways.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Ezagouri S,Zwighaft Z,Sobel J,Baillieul S,Doutreleau S,Ladeuix B,Golik M,Verges S,Asher Gdoi
10.1016/j.cmet.2019.03.012subject
Has Abstractpub_date
2019-07-02 00:00:00pages
78-91.e4issue
1eissn
1550-4131issn
1932-7420pii
S1550-4131(19)30141-Xjournal_volume
30pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract::Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and skeletal muscle, which shares a common progenitor with BAT, are dramatically decreased in mice placed on a high-fat diet and in obese humans. Expressio...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.11.005
更新日期:2012-12-05 00:00:00
abstract::Mutations resulting in reduced signaling of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis are associated with increased life- and healthspan across model organisms. Similar findings have been noted in human cohorts with functional mutations in the somatotropic axis, suggesting that this pathway may a...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2016.05.014
更新日期:2016-06-14 00:00:00
abstract::Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be optimized by intermittent dietary energy restriction (ER) and exercise. Such energetic challenges engage adaptive cellular stress-response signaling pathways in neu...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2012.08.012
更新日期:2012-12-05 00:00:00
abstract::One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid homeostasis (glycine, serine, and methionine), epigenetic maintenance, and redox defense. Both within eukaryotic cells and across organs, 1C metabolic r...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2016.08.009
更新日期:2017-01-10 00:00:00
abstract::The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing ne...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2012.10.007
更新日期:2012-11-07 00:00:00
abstract::The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mice, we show that βK...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2014.07.012
更新日期:2014-10-07 00:00:00
abstract::The brain is the most cholesterol-rich organ in the body, most of which comes from in situ synthesis. Here we demonstrate that in insulin-deficient diabetic mice, there is a reduction in expression of the major transcriptional regulator of cholesterol metabolism, SREBP-2, and its downstream genes in the hypothalamus a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.11.006
更新日期:2010-12-01 00:00:00
abstract::Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in g...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.04.005
更新日期:2009-05-01 00:00:00
abstract::Leptin activates the long form of the leptin receptor (LRb) to control feeding and neuroendocrine function and thus regulate adiposity. While adiposity influences insulin sensitivity, leptin also regulates glucose homeostasis independently of energy balance. Disruption of the LRb/STAT3 signal in s/s mice results in hy...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2005.02.001
更新日期:2005-03-01 00:00:00
abstract::Pancreatic islet beta cell mass expands in response to certain physiological conditions such as pregnancy and obesity, but the signaling pathways involved are not well understood. Possible insights come from a newly described regulatory circuit through which obesity-enhanced kinase signaling in the liver triggers expa...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.12.009
更新日期:2009-01-07 00:00:00
abstract::Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, dec...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.05.024
更新日期:2016-06-14 00:00:00
abstract::Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and c...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.10.005
更新日期:2007-11-01 00:00:00
abstract::Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA translation through PERK-mediated phosphorylation of eukaryotic initiation factor 2 on Ser51 of the alpha subunit (eIF2alpha). To elucidate the role of eIF2alpha phosphorylation, we engineered mice for conditional expression of homo...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.06.002
更新日期:2009-07-01 00:00:00
abstract::Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2016.07.014
更新日期:2016-08-09 00:00:00
abstract::Although variants in the IGF2BP2/IMP2 gene confer risk for type 2 diabetes, IMP2, an RNA binding protein, is not known to regulate metabolism. Imp2(-/-) mice gain less lean mass after weaning and have increased lifespan. Imp2(-/-) mice are highly resistant to diet-induced obesity and fatty liver and display superior g...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.03.006
更新日期:2015-04-07 00:00:00
abstract::Because MYC plays a causal role in many human cancers, including those with hypoxic and nutrient-poor tumor microenvironments, we have determined the metabolic responses of a MYC-inducible human Burkitt lymphoma model P493 cell line to aerobic and hypoxic conditions, and to glucose deprivation, using stable isotope-re...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.12.009
更新日期:2012-01-04 00:00:00
abstract::Defects in insulin secretion play a central role in the pathogenesis of type 2 diabetes, yet the mechanisms driving beta-cell dysfunction remain poorly understood, and therapies to preserve glucose-dependent insulin release are inadequate. We report a luminescent insulin secretion assay that enables large-scale invest...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2014.12.010
更新日期:2015-01-06 00:00:00
abstract::We caught up with some of the leading researchers in the NAD+ metabolism and signaling field as they gathered in Dublin for the 2019 FASEB Science Research Conference. Here they share their excitement from the rich history of NAD+ biology dating back over 100 years ago to a future of translation benefiting human healt...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.06.013
更新日期:2019-07-02 00:00:00
abstract::Mammalian organs are nourished by nutrients carried by the blood circulation. These nutrients originate from diet and internal stores, and can undergo various interconversions before their eventual use as tissue fuel. Here we develop isotope tracing, mass spectrometry, and mathematical analysis methods to determine th...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.07.013
更新日期:2020-10-06 00:00:00
abstract::Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.02.012
更新日期:2020-04-07 00:00:00
abstract::Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3 was shown to promote the expression of autophagy-related genes in skeletal muscle, the mechanisms triggering autophagy are unclear. We show that TSC1-deficient m...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.03.015
更新日期:2013-05-07 00:00:00
abstract::Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with am...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.08.017
更新日期:2019-09-03 00:00:00
abstract::The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are interlinked, opposing signaling pathways involved in sensing availability of nutrients and energy and regulation of cell growth. AMPK (Yin, or the "dark side") is switched on by lack of energy or nutrients and inhibits cell growth, whil...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2020.01.015
更新日期:2020-03-03 00:00:00
abstract::Over the past years, plenty of evidence has emerged illustrating how metabolism supports many aspects of cellular function and how metabolic reprogramming can drive cell differentiation and fate. Here, we present a method to assess the metabolic configuration of single cells within their native tissue microenvironment...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2017.08.014
更新日期:2017-11-07 00:00:00
abstract::Almost always, obesity is an obligate prerequisite for the development of type 2 diabetes mellitus. Loss of a well-known lipid phosphatase appears to prevent insulin-resistant diabetes in mice by removal of a positive regulator of adiposity. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2005.01.007
更新日期:2005-02-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse that we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.02.004
更新日期:2015-03-03 00:00:00
abstract::Type 2 diabetes is an epidemic disease worldwide, but it is difficult to predict its appearance in the general population. A recent study demonstrates that circulating concentrations of a small group of essential amino acids predict risk for diabetes, contributing to a recent resurgence of interest in these common ana...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2011.04.003
更新日期:2011-05-04 00:00:00
abstract::Sphingolipids have garnered attention for their role in insulin resistance and lipotoxic cell death. We have developed transgenic mice inducibly expressing acid ceramidase that display a reduction in ceramides in adult mouse tissues. Hepatic overexpression of acid ceramidase prevents hepatic steatosis and prompts impr...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.06.007
更新日期:2015-08-04 00:00:00
abstract::The mitochondrial contact site and cristae organizing system (MICOS) is a conserved multi-subunit complex crucial for maintaining the characteristic architecture of mitochondria. Studies with deletion mutants identified Mic10 and Mic60 as core subunits of MICOS. Mic60 has been studied in detail; however, topogenesis a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.04.007
更新日期:2015-05-05 00:00:00
abstract::The past 25 years have witnessed major advances in our knowledge of how exercise activates cellular, molecular, and biochemical pathways with regulatory roles in training response adaptation, and how muscle "cross-talk" with other organs is a mechanism by which physical activity exerts its beneficial effects on "whole...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2015.06.016
更新日期:2015-07-07 00:00:00