Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory.

Abstract:

:While mesenchymal stem cells (MSCs) are rapidly cleared from the body following systemic transplantation, their therapeutic benefits typically persist. In this issue, Liu et al. (2015) reveal that the ability of transplanted MSCs to alleviate osteoporosis in systemic lupus erythematosus is maintained through epigenetic changes conferred by secretory action of the MSCs.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Ng KS,Kuncewicz TM,Karp JM

doi

10.1016/j.cmet.2015.09.019

subject

Has Abstract

pub_date

2015-10-06 00:00:00

pages

541-3

issue

4

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(15)00476-3

journal_volume

22

pub_type

评论,杂志文章
  • One-Carbon Metabolism in Health and Disease.

    abstract::One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid homeostasis (glycine, serine, and methionine), epigenetic maintenance, and redox defense. Both within eukaryotic cells and across organs, 1C metabolic r...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2016.08.009

    authors: Ducker GS,Rabinowitz JD

    更新日期:2017-01-10 00:00:00

  • Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis.

    abstract::Leptin activates the long form of the leptin receptor (LRb) to control feeding and neuroendocrine function and thus regulate adiposity. While adiposity influences insulin sensitivity, leptin also regulates glucose homeostasis independently of energy balance. Disruption of the LRb/STAT3 signal in s/s mice results in hy...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2005.02.001

    authors: Bates SH,Kulkarni RN,Seifert M,Myers MG Jr

    更新日期:2005-03-01 00:00:00

  • The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease.

    abstract::Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key componen...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2019.10.010

    authors: Kisseleva T,Brenner DA

    更新日期:2019-11-05 00:00:00

  • Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation.

    abstract::Mammalian cells detect decreases in oxygen concentrations to activate a variety of responses that help cells adapt to low oxygen levels (hypoxia). One such response is stabilization of the protein HIF-1 alpha, a component of the transcription factor HIF-1. Here we show that a small interfering RNA (siRNA) against the ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2005.05.002

    authors: Brunelle JK,Bell EL,Quesada NM,Vercauteren K,Tiranti V,Zeviani M,Scarpulla RC,Chandel NS

    更新日期:2005-06-01 00:00:00

  • Hypothalamic tanycytes: gatekeepers to metabolic control.

    abstract::How circulating signals of hunger and satiety enter the brain to reach neurons that govern energy balance has long remained a matter of controversy and speculation. Balland et al. (2014) now elucidate molecular mechanisms by which a highly specialized hypothalamic glial cell regulates transport of leptin across the bl...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2014.01.008

    authors: Gao Y,Tschöp MH,Luquet S

    更新日期:2014-02-04 00:00:00

  • Fasting the Microbiota to Improve Metabolism?

    abstract::While intermittent or periodic fasting provides a variety of favorable health benefits, the molecular mediators of these effects are poorly understood. In this issue of Cell Metabolism, Li and colleagues (2017) highlight the role of gut microbiota in mediating benefits of intermittent fasting through activation of adi...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.09.013

    authors: Haas JT,Staels B

    更新日期:2017-10-03 00:00:00

  • The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity.

    abstract::Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However, how cold activates type 2 immunity in WAT remains obscure. Here we show that cold-induced type 2 immune responses and beiging in subcutaneous WAT (scWAT) are abro...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.08.003

    authors: Huang Z,Zhong L,Lee JTH,Zhang J,Wu D,Geng L,Wang Y,Wong CM,Xu A

    更新日期:2017-09-05 00:00:00

  • Dynamics of an Aging Genome.

    abstract::The genetic mechanisms mediating longevity and maximum lifespan of the human species are likely different than those explaining differences in life expectancy and healthspan across individuals. Both of these perspectives are important and can be separated and explored using genomic data. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.06.002

    authors: Telenti A,Perkins BA,Venter JC

    更新日期:2016-06-14 00:00:00

  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

    abstract::CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or oxidative metabolic programs in vitro, requirements and mechanisms that control T cell glucose uptake and metabolism in viv...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2014.05.004

    authors: Macintyre AN,Gerriets VA,Nichols AG,Michalek RD,Rudolph MC,Deoliveira D,Anderson SM,Abel ED,Chen BJ,Hale LP,Rathmell JC

    更新日期:2014-07-01 00:00:00

  • Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.

    abstract::Oxidative stress causes mitochondrial dysfunction and metabolic complications through unknown mechanisms. Cardiolipin (CL) is a key mitochondrial phospholipid required for oxidative phosphorylation. Oxidative damage to CL from pathological remodeling is implicated in the etiology of mitochondrial dysfunction commonly ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2010.07.003

    authors: Li J,Romestaing C,Han X,Li Y,Hao X,Wu Y,Sun C,Liu X,Jefferson LS,Xiong J,Lanoue KF,Chang Z,Lynch CJ,Wang H,Shi Y

    更新日期:2010-08-04 00:00:00

  • Can exercise mimetics substitute for exercise?

    abstract::Exercise leads to changes in muscle phenotype with important implications for exercise performance and health. A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2008.07.004

    authors: Richter EA,Kiens B,Wojtaszewski JF

    更新日期:2008-08-01 00:00:00

  • SHIPing news: a new way to keep your weight down.

    abstract::Almost always, obesity is an obligate prerequisite for the development of type 2 diabetes mellitus. Loss of a well-known lipid phosphatase appears to prevent insulin-resistant diabetes in mice by removal of a positive regulator of adiposity. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2005.01.007

    authors: Birnbaum MJ

    更新日期:2005-02-01 00:00:00

  • Increased internal and external bacterial load during Drosophila aging without life-span trade-off.

    abstract::The role of microbial load during aging of the adult fruit fly Drosophila melanogaster is incompletely understood. Here we show dramatic increases in aerobic and anaerobic bacterial load during aging, both inside the body and on the surface. Scanning electron microscopy and cell staining analyses of the surface of age...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2007.06.006

    authors: Ren C,Webster P,Finkel SE,Tower J

    更新日期:2007-08-01 00:00:00

  • BDNF (I)rising from exercise.

    abstract::Exercise produces many beneficial effects on brain health, in part by increasing hippocampal BDNF levels; however, the mechanism underlying BDNF gene regulation remains unknown. In this issue of Cell Metabolism, Wrann et al. (2013) show that exercise induces hippocampal Bdnf expression by stimulating expression of FND...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2013.10.008

    authors: Xu B

    更新日期:2013-11-05 00:00:00

  • Setting the tone: reactive oxygen species and the control of appetitive melanocortin neurons.

    abstract::The brain melanocortin system is a primary gateway through which energy balance is controlled. Diano and colleagues report a novel cellular mechanism mediated via reactive oxygen species (ROS) that regulates the activity of these melanocortin neurons in response to energy status, thereby modulating appetitive behavior...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2011.10.004

    authors: Rochford JJ,Myers MG Jr,Heisler LK

    更新日期:2011-11-02 00:00:00

  • Palatability Can Drive Feeding Independent of AgRP Neurons.

    abstract::Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.07.011

    authors: Denis RG,Joly-Amado A,Webber E,Langlet F,Schaeffer M,Padilla SL,Cansell C,Dehouck B,Castel J,Delbès AS,Martinez S,Lacombe A,Rouch C,Kassis N,Fehrentz JA,Martinez J,Verdié P,Hnasko TS,Palmiter RD,Krashes MJ,Güler A

    更新日期:2015-10-06 00:00:00

  • Mitochondrial medicine: a metabolic perspective on the pathology of oxidative phosphorylation disorders.

    abstract::The final steps in the production of adenosine triphosphate (ATP) in mitochondria are executed by a series of multisubunit complexes and electron carriers, which together constitute the oxidative phosphorylation (OXPHOS) system. OXPHOS is under dual genetic control, with communication between the nuclear and mitochond...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2005.12.001

    authors: Smeitink JA,Zeviani M,Turnbull DM,Jacobs HT

    更新日期:2006-01-01 00:00:00

  • Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.

    abstract::CD147 is a tumor-associated glycoprotein that regulates cell metabolism. However, CD147 methylation and its subsequent role in cancer cell metabolism remain unclear. Here, we detect CD147 di-methylation in 16 non-small-cell lung cancer (NSCLC) tissues using liquid chromatography-tandem mass spectrometry. CD147 is di-m...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.12.010

    authors: Wang K,Huang W,Chen R,Lin P,Zhang T,Ni YF,Li H,Wu J,Sun XX,Geng JJ,Zhu YM,Nan G,Zhang W,Chen X,Zhu P,Bian H,Chen ZN

    更新日期:2021-01-05 00:00:00

  • A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.

    abstract::One of the hallmarks of type 2 diabetes is that pancreatic beta cells fail to release sufficient amounts of insulin in the presence of elevated blood glucose levels. Insulin secretion is modulated by many hormones and neurotransmitters including acetylcholine, the major neurotransmitter of the peripheral parasympathet...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2006.04.009

    authors: Gautam D,Han SJ,Hamdan FF,Jeon J,Li B,Li JH,Cui Y,Mears D,Lu H,Deng C,Heard T,Wess J

    更新日期:2006-06-01 00:00:00

  • Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.

    abstract::Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue culture are much higher than what has been described in vivo. Here...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.09.006

    authors: Gui DY,Sullivan LB,Luengo A,Hosios AM,Bush LN,Gitego N,Davidson SM,Freinkman E,Thomas CJ,Vander Heiden MG

    更新日期:2016-11-08 00:00:00

  • Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step.

    abstract::A hypothesis that accounts for most of the available literature on insulin-stimulated GLUT4 translocation is that insulin action controls the access of GLUT4 vesicles to a constitutively active plasma-membrane fusion process. However, using an in vitro fusion assay, we show here that fusion is not constitutively activ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2005.08.007

    authors: Koumanov F,Jin B,Yang J,Holman GD

    更新日期:2005-09-01 00:00:00

  • Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments.

    abstract::Over the past years, plenty of evidence has emerged illustrating how metabolism supports many aspects of cellular function and how metabolic reprogramming can drive cell differentiation and fate. Here, we present a method to assess the metabolic configuration of single cells within their native tissue microenvironment...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.08.014

    authors: Miller A,Nagy C,Knapp B,Laengle J,Ponweiser E,Groeger M,Starkl P,Bergmann M,Wagner O,Haschemi A

    更新日期:2017-11-07 00:00:00

  • Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation.

    abstract::The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.02.012

    authors: Abraham RT

    更新日期:2016-03-08 00:00:00

  • The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.

    abstract::Polg mtDNA mutator mice are important models for investigating the role of acquired mtDNA mutations in aging. Despite extensive study, there remains little consensus on either the etiology of the progeroid phenotype or the mtDNA mutation spectrum induced by disrupted polymerase-γ function. To investigate the latter, w...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2010.11.012

    authors: Williams SL,Huang J,Edwards YJ,Ulloa RH,Dillon LM,Prolla TA,Vance JM,Moraes CT,Züchner S

    更新日期:2010-12-01 00:00:00

  • The emerging genetic architecture of type 2 diabetes.

    abstract::Type 2 diabetes is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. Previous studies using a candidate gene approach, family linkage studies, and gene expression profiling uncov...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2008.08.006

    authors: Doria A,Patti ME,Kahn CR

    更新日期:2008-09-01 00:00:00

  • Enriching the Circadian Proteome.

    abstract::Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2016.12.014

    authors: Takahashi JS

    更新日期:2017-01-10 00:00:00

  • Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response.

    abstract::Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.06.010

    authors: Wang QP,Lin YQ,Zhang L,Wilson YA,Oyston LJ,Cotterell J,Qi Y,Khuong TM,Bakhshi N,Planchenault Y,Browman DT,Lau MT,Cole TA,Wong AC,Simpson SJ,Cole AR,Penninger JM,Herzog H,Neely GG

    更新日期:2016-07-12 00:00:00

  • NAD+ Metabolism and Signaling.

    abstract::We caught up with some of the leading researchers in the NAD+ metabolism and signaling field as they gathered in Dublin for the 2019 FASEB Science Research Conference. Here they share their excitement from the rich history of NAD+ biology dating back over 100 years ago to a future of translation benefiting human healt...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.06.013

    authors:

    更新日期:2019-07-02 00:00:00

  • Purloined mechanisms of bacterial immunity can cure muscular dystrophy.

    abstract::Myriad strategies have been explored to compensate for the lack of dystrophin or to skip mutations that cause the lethal disease Duchenne muscular dystrophy (DMD). A new study shows that gene editing strategies used by bacteria can be applied in zygotes of a mouse model of DMD to correct the genetic defect that causes...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2014.11.011

    authors: Tidball JG,Bertoni C

    更新日期:2014-12-02 00:00:00

  • Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in Western societies, affecting one in four adults in the USA, and is strongly associated with hepatic insulin resistance, a major risk factor in the pathogenesis of type 2 diabetes. Although the cellular mechanisms underlying this...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2012.03.005

    authors: Jornayvaz FR,Shulman GI

    更新日期:2012-05-02 00:00:00