Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation.

Abstract:

:The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Abraham RT

doi

10.1016/j.cmet.2016.02.012

subject

Has Abstract

pub_date

2016-03-08 00:00:00

pages

397-8

issue

3

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(16)30061-4

journal_volume

23

pub_type

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