Abstract：
:Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of Socs-3, or those with neuronal deletion of Socs-3, are lean and more leptin and insulin sensitive. To examine the role of Socs-3 within specific neurons critical to energy balance, we created mice with selective deletion of Socs-3 within pro-opiomelanocortin (POMC)-expressing cells. These mice had enhanced leptin sensitivity, measured by weight loss and food intake after leptin infusion. On chow diet, glucose homeostasis was improved despite normal weight gain. On a high-fat diet, the rate of weight gain was reduced, due to increased energy expenditure rather than decreased food intake; glucose homeostasis and insulin sensitivity were substantially improved. These studies demonstrate that Socs-3 within POMC neurons regulates leptin sensitivity and glucose homeostasis, and plays a key role in linking high-fat diet to disordered metabolism.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Kievit P,Howard JK,Badman MK,Balthasar N,Coppari R,Mori H,Lee CE,Elmquist JK,Yoshimura A,Flier JSdoi
10.1016/j.cmet.2006.06.010subject
Has Abstractpub_date
2006-08-01 00:00:00pages
123-32issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(06)00242-7journal_volume
4pub_type
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