Abstract:
:The brain melanocortin system is a primary gateway through which energy balance is controlled. Diano and colleagues report a novel cellular mechanism mediated via reactive oxygen species (ROS) that regulates the activity of these melanocortin neurons in response to energy status, thereby modulating appetitive behavior (Diano et al., 2011).
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Rochford JJ,Myers MG Jr,Heisler LKdoi
10.1016/j.cmet.2011.10.004subject
Has Abstractpub_date
2011-11-02 00:00:00pages
573-4issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(11)00390-1journal_volume
14pub_type
评论,杂志文章相关文献
Cell Metabolism文献大全abstract::Mammalian cells detect decreases in oxygen concentrations to activate a variety of responses that help cells adapt to low oxygen levels (hypoxia). One such response is stabilization of the protein HIF-1 alpha, a component of the transcription factor HIF-1. Here we show that a small interfering RNA (siRNA) against the ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2005.05.002
更新日期:2005-06-01 00:00:00
abstract::The ability of hormones such as insulin, leptin, and cholecystokinin to alter food intake is influenced by intricate interactions between homeostatic and non-homeostatic factors. Consequently, when administered exogenously, the likelihood of these hormones influencing food intake is probabilistic, leading to difficult...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.08.017
更新日期:2015-09-01 00:00:00
abstract::Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD(+) biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in mammals. However, the significance of eNAMPT secretion remains unclear. Here we demonstrate that deacetylation of iNAMPT by the mammalian NAD(+)-dependent deacet...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.04.002
更新日期:2015-05-05 00:00:00
abstract::Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue culture are much higher than what has been described in vivo. Here...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.09.006
更新日期:2016-11-08 00:00:00
abstract::Nuclear receptor signaling plays an important role in energy metabolism. In this study we demonstrate that the nuclear receptor corepressor RIP140 is a key regulator of metabolism in skeletal muscle. RIP140 is expressed in a fiber type-specific manner, and manipulation of its levels in null, heterozygous, and transgen...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.08.004
更新日期:2007-09-01 00:00:00
abstract::Mammary epithelial cells transition between periods of proliferation and quiescence during development, menstrual cycles, and pregnancy, and as a result of oncogenic transformation. Utilizing an organotypic 3D tissue culture model coupled with quantitative metabolomics and proteomics, we identified significant differe...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.03.016
更新日期:2016-05-10 00:00:00
abstract::In the face of the current obesity epidemic, the nature of the relationship between overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state of excessive insulin action that elicits a series of cellular homeostatic responses, producing systemic insulin resistance. These responses occ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.03.001
更新日期:2012-06-06 00:00:00
abstract::Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-elusive metabolic circuitries. Here, we show that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autopha...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2014.02.010
更新日期:2014-03-04 00:00:00
abstract::Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed th...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2014.03.020
更新日期:2014-04-01 00:00:00
abstract::Macrophages infiltrate adipose tissue in obesity and are involved in the induction of inflammation, thereby contributing to the development of obesity-associated metabolic disorders. Here, we show that the macrophage-derived soluble protein AIM is endocytosed into adipocytes via CD36. Within adipocytes, AIM associates...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.04.013
更新日期:2010-06-09 00:00:00
abstract::Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of Socs-3, or those with neuronal deletion of Socs-3, are lean and more leptin and insulin sensitive. To examine the role of Socs-3 within...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2006.06.010
更新日期:2006-08-01 00:00:00
abstract::Medial nucleus tractus solitarius (mNTS) neurons express leptin receptors (LepRs), and intra-mNTS delivery of leptin reduces food intake and body weight. Here, the contribution of endogenous LepR signaling in mNTS neurons to energy balance control was examined. Knockdown of LepR in mNTS and area postrema (AP) neurons ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.10.009
更新日期:2010-01-01 00:00:00
abstract::Despite the prevalence of obesity and its related diseases, the signaling pathways for appetite control and satiety are not clearly understood. Here we report C. elegans quiescence behavior, a cessation of food intake and movement that is possibly a result of satiety. C. elegans quiescence shares several characteristi...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.01.005
更新日期:2008-03-01 00:00:00
abstract::Studying ciliopathies, like the Bardet-Biedl syndrome (BBS), allow the identification of signaling pathways potentially involved in common diseases, sharing phenotypic features like obesity or type 2 diabetes. Given the close association between obesity and insulin resistance, obese BBS patients would be expected to b...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.08.005
更新日期:2012-09-05 00:00:00
abstract::Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents was oxidized, cysteine-nitrosylated, and deplet...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.05.014
更新日期:2011-08-03 00:00:00
abstract::The polarization of adipose tissue-resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, the mechanisms controlling tissue macrophage activation remain unclear. Here we show that adipocytes are a source of Th2 cytokines, including I...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.04.002
更新日期:2008-06-01 00:00:00
abstract::Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not expres...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.03.016
更新日期:2011-05-04 00:00:00
abstract::Virus infections trigger metabolic changes in host cells that support the bioenergetic and biosynthetic demands of viral replication. Although recent studies have characterized virus-induced changes in host cell metabolism (Munger et al., 2008; Terry et al., 2012), the molecular mechanisms by which viruses reprogram c...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2014.03.009
更新日期:2014-04-01 00:00:00
abstract::Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy metabolism in the heart. Here, we propose a mechanism that integrates two deleterious characteristics of heart failure, hypoxia and a metabolic shift toward glycolysis, involving the microRNA cluster miR-199a∼214 and PPARδ. We demon...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.08.009
更新日期:2013-09-03 00:00:00
abstract::Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlatio...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.04.012
更新日期:2020-05-05 00:00:00
abstract::Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.02.012
更新日期:2020-04-07 00:00:00
abstract::The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2014.09.010
更新日期:2014-11-04 00:00:00
abstract::Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and c...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.10.005
更新日期:2007-11-01 00:00:00
abstract::Cholesteryl ester accumulation by macrophages is a critical early event in atherogenesis. To test the hypothesis that sterol loading promotes foam cell formation and vascular disease by perturbing a network of interacting proteins, we used a global approach to identify proteins that are differentially expressed when m...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.01.003
更新日期:2010-02-03 00:00:00
abstract::Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycer...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2008.02.002
更新日期:2008-03-01 00:00:00
abstract::Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN prote...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.08.023
更新日期:2015-11-03 00:00:00
abstract::In flies, ecdysone integrates growth with developmental transitions by antagonizing insulin signaling, which links growth with nutritional status. Work in Developmental Cell (Delanoue et. al, 2010) finds that ecdysone represses the transcription factor Myc in the larval fat body to inhibit systemic growth, revealing a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.06.003
更新日期:2010-07-07 00:00:00
abstract::Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.12.013
更新日期:2016-01-12 00:00:00
abstract::VEGF (vascular endothelial growth factor) signaling inhibitors are widely used in different cancer types; however, patient selection remains a challenge. Analyses of samples from a phase III clinical trial in metastatic colorectal cancer testing chemotherapy versus chemotherapy with the small molecule VEGF receptors i...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.10.015
更新日期:2016-01-12 00:00:00
abstract::With the identification of its receptor in a highly specific region of the brain, interesting issues come to light regarding the normal physiological functions of GDF15, a secreted protein long identified as a biomarker of diverse disease states. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2017.10.017
更新日期:2017-12-05 00:00:00