Food for Thought: Revisiting the Complexity of Food Intake.


:The ability of hormones such as insulin, leptin, and cholecystokinin to alter food intake is influenced by intricate interactions between homeostatic and non-homeostatic factors. Consequently, when administered exogenously, the likelihood of these hormones influencing food intake is probabilistic, leading to difficulties replicating previously reported outcomes both within and between labs.


Cell Metab


Cell metabolism


Woods SC,Begg DP




Has Abstract


2015-09-01 00:00:00














  • Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin.

    abstract::Mitochondria are dynamic organelles that have been linked to stem cell homeostasis. However, the mechanisms involved in mitochondrial regulation of stem cell fate determination remain elusive. Here we discover that epithelial-mesenchymal transition (EMT), a key process in cancer progression, induces mitochondrial fusi...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Wu MJ,Chen YS,Kim MR,Chang CC,Gampala S,Zhang Y,Wang Y,Chang CY,Yang JY,Chang CJ

    更新日期:2019-04-02 00:00:00

  • The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis.

    abstract::Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Pemt(-/-) mice fed a choline-deficient (CD) diet develop rapid steatohepatitis ...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Li Z,Agellon LB,Allen TM,Umeda M,Jewell L,Mason A,Vance DE

    更新日期:2006-05-01 00:00:00

  • Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN.

    abstract::Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the contr...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Shi YC,Lau J,Lin Z,Zhang H,Zhai L,Sperk G,Heilbronn R,Mietzsch M,Weger S,Huang XF,Enriquez RF,Baldock PA,Zhang L,Sainsbury A,Herzog H,Lin S

    更新日期:2013-02-05 00:00:00

  • Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments.

    abstract::Over the past years, plenty of evidence has emerged illustrating how metabolism supports many aspects of cellular function and how metabolic reprogramming can drive cell differentiation and fate. Here, we present a method to assess the metabolic configuration of single cells within their native tissue microenvironment...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Miller A,Nagy C,Knapp B,Laengle J,Ponweiser E,Groeger M,Starkl P,Bergmann M,Wagner O,Haschemi A

    更新日期:2017-11-07 00:00:00

  • ERRγ-A New Player in β Cell Maturation.

    abstract::Glucose and hormone responsiveness of pancreatic β cells is acquired during postnatal maturation and is critical for appropriate insulin secretion. In a recent issue of Cell Metabolism, Yoshihara et al. (2016) report that estrogen-related receptor γ (ERRγ) promotes functional maturation of both mouse neonatal β cells ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Shirakawa J,Kulkarni RN

    更新日期:2016-05-10 00:00:00

  • Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases.

    abstract::Most mitochondrial proteins are imported by the translocase of the outer mitochondrial membrane (TOM). Tom22 functions as central receptor and transfers preproteins to the import pore. Casein kinase 2 (CK2) constitutively phosphorylates the cytosolic precursor of Tom22 at Ser44 and Ser46 and, thus, promotes its import...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Gerbeth C,Schmidt O,Rao S,Harbauer AB,Mikropoulou D,Opalińska M,Guiard B,Pfanner N,Meisinger C

    更新日期:2013-10-01 00:00:00

  • The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.

    abstract::The two p160 transcriptional coregulator family members SRC-1 and TIF2 have important metabolic functions in white and brown adipose tissues as well as in the liver. To analyze TIF2 cell-autonomous functions in skeletal muscles, we generated TIF2((i)skm)⁻(/)⁻ mice in which TIF2 was selectively ablated in skeletal musc...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Duteil D,Chambon C,Ali F,Malivindi R,Zoll J,Kato S,Geny B,Chambon P,Metzger D

    更新日期:2010-11-03 00:00:00

  • Light activates the adrenal gland: timing of gene expression and glucocorticoid release.

    abstract::Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to improve metabolic and hormonal status of circadian rhythm sleep disorders, although its mechanism is poorly understood. In the present study, we revealed that light induces gene expression in the adrenal gland via the supra...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Ishida A,Mutoh T,Ueyama T,Bando H,Masubuchi S,Nakahara D,Tsujimoto G,Okamura H

    更新日期:2005-11-01 00:00:00

  • Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

    abstract::Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: López M,Lage R,Saha AK,Pérez-Tilve D,Vázquez MJ,Varela L,Sangiao-Alvarellos S,Tovar S,Raghay K,Rodríguez-Cuenca S,Deoliveira RM,Castañeda T,Datta R,Dong JZ,Culler M,Sleeman MW,Alvarez CV,Gallego R,Lelliott CJ,Carlin

    更新日期:2008-05-01 00:00:00

  • Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.

    abstract::Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 mon...

    journal_title:Cell metabolism

    pub_type: 临床试验,杂志文章


    authors: Greggio C,Jha P,Kulkarni SS,Lagarrigue S,Broskey NT,Boutant M,Wang X,Conde Alonso S,Ofori E,Auwerx J,Cantó C,Amati F

    更新日期:2017-02-07 00:00:00

  • A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.

    abstract::One of the hallmarks of type 2 diabetes is that pancreatic beta cells fail to release sufficient amounts of insulin in the presence of elevated blood glucose levels. Insulin secretion is modulated by many hormones and neurotransmitters including acetylcholine, the major neurotransmitter of the peripheral parasympathet...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Gautam D,Han SJ,Hamdan FF,Jeon J,Li B,Li JH,Cui Y,Mears D,Lu H,Deng C,Heard T,Wess J

    更新日期:2006-06-01 00:00:00

  • Imaging obesity: fMRI, food reward, and feeding.

    abstract::Animal studies have revealed brain regions that control homeostatic feeding, but the rampant overeating contributing to the obesity epidemic suggests the participation of "nonhomeostatic" control centers. Recent papers by Batterham et al. (2007) and Farooqi et al. (2007) link peptide YY(3-36) and leptin to the activat...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Grill HJ,Skibicka KP,Hayes MR

    更新日期:2007-12-01 00:00:00

  • Insulin resistance in the defense against obesity.

    abstract::In the face of the current obesity epidemic, the nature of the relationship between overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state of excessive insulin action that elicits a series of cellular homeostatic responses, producing systemic insulin resistance. These responses occ...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Saltiel AR

    更新日期:2012-06-06 00:00:00

  • The metabolic sensor GCN2 branches out.

    abstract::GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid depr...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Towle HC

    更新日期:2007-02-01 00:00:00

  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

    abstract::CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or oxidative metabolic programs in vitro, requirements and mechanisms that control T cell glucose uptake and metabolism in viv...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Macintyre AN,Gerriets VA,Nichols AG,Michalek RD,Rudolph MC,Deoliveira D,Anderson SM,Abel ED,Chen BJ,Hale LP,Rathmell JC

    更新日期:2014-07-01 00:00:00

  • DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and me...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Ahrens M,Ammerpohl O,von Schönfels W,Kolarova J,Bens S,Itzel T,Teufel A,Herrmann A,Brosch M,Hinrichsen H,Erhart W,Egberts J,Sipos B,Schreiber S,Häsler R,Stickel F,Becker T,Krawczak M,Röcken C,Siebert R,Schafmayer

    更新日期:2013-08-06 00:00:00

  • Setting the tone: reactive oxygen species and the control of appetitive melanocortin neurons.

    abstract::The brain melanocortin system is a primary gateway through which energy balance is controlled. Diano and colleagues report a novel cellular mechanism mediated via reactive oxygen species (ROS) that regulates the activity of these melanocortin neurons in response to energy status, thereby modulating appetitive behavior...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Rochford JJ,Myers MG Jr,Heisler LK

    更新日期:2011-11-02 00:00:00

  • Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans.

    abstract::Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Chen KY,Cypess AM,Laughlin MR,Haft CR,Hu HH,Bredella MA,Enerbäck S,Kinahan PE,Lichtenbelt Wv,Lin FI,Sunderland JJ,Virtanen KA,Wahl RL

    更新日期:2016-08-09 00:00:00

  • RNA-Targeted Therapeutics.

    abstract::RNA-targeted therapies represent a platform for drug discovery involving chemically modified oligonucleotides, a wide range of cellular RNAs, and a novel target-binding motif, Watson-Crick base pairing. Numerous hurdles considered by many to be impassable have been overcome. Today, four RNA-targeted therapies are appr...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Crooke ST,Witztum JL,Bennett CF,Baker BF

    更新日期:2018-04-03 00:00:00

  • Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation.

    abstract::Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes in the gut microbiota appear to be important. The inhibitory role of mic...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Koh A,Mannerås-Holm L,Yunn NO,Nilsson PM,Ryu SH,Molinaro A,Perkins R,Smith JG,Bäckhed F

    更新日期:2020-10-06 00:00:00

  • TOR signaling and S6 kinase 1: Yeast catches up.

    abstract::Conservation of the rapamycin-sensitive TOR signaling network among eukaryotes has been instrumental to the rapid progress made in this field in recent years. A recent report in Molecular Cell (Urban et al., 2007) now extends this conservation to include Sch9, an AGC protein kinase family member from S. cerevisiae, wh...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章,评审


    authors: Powers T

    更新日期:2007-07-01 00:00:00

  • Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.

    abstract::The canonical notion that type 1 diabetes (T1D) results following a complete destruction of β cells has recently been questioned as small amounts of C-peptide are detectable in patients with long-standing disease. We analyzed protein and gene expression levels for proinsulin, insulin, C-peptide, and islet amyloid poly...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Wasserfall C,Nick HS,Campbell-Thompson M,Beachy D,Haataja L,Kusmartseva I,Posgai A,Beery M,Rhodes C,Bonifacio E,Arvan P,Atkinson M

    更新日期:2017-09-05 00:00:00

  • Leptin does not directly affect CNS serotonin neurons to influence appetite.

    abstract::Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not expres...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Lam DD,Leinninger GM,Louis GW,Garfield AS,Marston OJ,Leshan RL,Scheller EL,Christensen L,Donato J Jr,Xia J,Evans ML,Elias C,Dalley JW,Burdakov DI,Myers MG Jr,Heisler LK

    更新日期:2011-05-04 00:00:00

  • Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.

    abstract::Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulation at the transcriptional level, much less is known about tempor...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Wang J,Mauvoisin D,Martin E,Atger F,Galindo AN,Dayon L,Sizzano F,Palini A,Kussmann M,Waridel P,Quadroni M,Dulić V,Naef F,Gachon F

    更新日期:2017-01-10 00:00:00

  • Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.

    abstract::Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur exclusively via the replication of existing beta cells, but clinically meaningful restoration of human beta cell mass by proliferation has never been achieved. We discovered a population of immature beta cells that is present through...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: van der Meulen T,Mawla AM,DiGruccio MR,Adams MW,Nies V,Dólleman S,Liu S,Ackermann AM,Cáceres E,Hunter AE,Kaestner KH,Donaldson CJ,Huising MO

    更新日期:2017-04-04 00:00:00

  • SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.

    abstract::Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) drives expression of genes regulating RCT, and its activity can be ...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Stein S,Oosterveer MH,Mataki C,Xu P,Lemos V,Havinga R,Dittner C,Ryu D,Menzies KJ,Wang X,Perino A,Houten SM,Melchior F,Schoonjans K

    更新日期:2014-10-07 00:00:00

  • Hypoxia-independent angiogenesis in adipose tissues during cold acclimation.

    abstract::The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here, we show that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues. In the inguinal depot, cold exposure resulted in elevated expression levels of brown-fat-ass...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Xue Y,Petrovic N,Cao R,Larsson O,Lim S,Chen S,Feldmann HM,Liang Z,Zhu Z,Nedergaard J,Cannon B,Cao Y

    更新日期:2009-01-07 00:00:00

  • JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.

    abstract::Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we demonstrate that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (BCSCs) and cancer chemoresistance. Inhibiting JAK/STAT3 blocks BCSC self...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Wang T,Fahrmann JF,Lee H,Li YJ,Tripathi SC,Yue C,Zhang C,Lifshitz V,Song J,Yuan Y,Somlo G,Jandial R,Ann D,Hanash S,Jove R,Yu H

    更新日期:2018-01-09 00:00:00

  • Bypassing Intestinal Sugar Enhancement of Sweet Appetite.

    abstract::Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Sclafani A

    更新日期:2016-01-12 00:00:00

  • Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk.

    abstract::The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing ne...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Holmes E,Li JV,Marchesi JR,Nicholson JK

    更新日期:2012-11-07 00:00:00