Abstract：
:Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) drives expression of genes regulating RCT, and its activity can be modified by different posttranslational modifications. Here, we show that atherosclerosis-prone mice carrying a mutation that abolishes SUMOylation of LRH-1 on K289R develop less aortic plaques than control littermates when exposed to a high-cholesterol diet. The mechanism underlying this atheroprotection involves an increase in RCT and its associated hepatic genes and is secondary to a compromised interaction of LRH-1 K289R with the corepressor prospero homeobox protein 1 (PROX1). Our study reveals that the SUMOylation status of a single nuclear receptor lysine residue can impact the development of a complex metabolic disease such as atherosclerosis.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Stein S,Oosterveer MH,Mataki C,Xu P,Lemos V,Havinga R,Dittner C,Ryu D,Menzies KJ,Wang X,Perino A,Houten SM,Melchior F,Schoonjans Kdoi
10.1016/j.cmet.2014.07.023subject
Has Abstractpub_date
2014-10-07 00:00:00pages
603-13issue
4eissn
1550-4131issn
1932-7420pii
S1550-4131(14)00331-3journal_volume
20pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract：:Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2015.02.011
更新日期：2015-03-03 00:00:00
abstract：:The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are required for ve...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2007.04.001
更新日期：2007-05-01 00:00:00
abstract：:Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of m...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.01.003
更新日期：2015-02-03 00:00:00
abstract：:The conversion of lipolysis-derived fatty acids into ketone bodies (ketogenesis) is a crucial metabolic adaptation to prolonged periods of food scarcity. The process occurs primarily in liver mitochondria and is initiated by fatty-acid-mediated stimulation of the ligand-operated transcription factor, peroxisome prolif...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.09.014
更新日期：2019-01-08 00:00:00
abstract：:One of the hallmarks of type 2 diabetes is that pancreatic beta cells fail to release sufficient amounts of insulin in the presence of elevated blood glucose levels. Insulin secretion is modulated by many hormones and neurotransmitters including acetylcholine, the major neurotransmitter of the peripheral parasympathet...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.04.009
更新日期：2006-06-01 00:00:00
abstract：:Although variants in the IGF2BP2/IMP2 gene confer risk for type 2 diabetes, IMP2, an RNA binding protein, is not known to regulate metabolism. Imp2(-/-) mice gain less lean mass after weaning and have increased lifespan. Imp2(-/-) mice are highly resistant to diet-induced obesity and fatty liver and display superior g...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.03.006
更新日期：2015-04-07 00:00:00
abstract：:Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed th...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2014.03.020
更新日期：2014-04-01 00:00:00
abstract：:RNA-targeted therapies represent a platform for drug discovery involving chemically modified oligonucleotides, a wide range of cellular RNAs, and a novel target-binding motif, Watson-Crick base pairing. Numerous hurdles considered by many to be impassable have been overcome. Today, four RNA-targeted therapies are appr...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2018.03.004
更新日期：2018-04-03 00:00:00
abstract：:Food intake and activity-induced thermogenesis are important components of energy balance regulation. The molecular mechanism underlying the coordination of food intake with locomotory behavior to maintain energy homeostasis is unclear. We report that the brain-specific homeobox transcription factor Bsx is required fo...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2007.05.007
更新日期：2007-06-01 00:00:00
abstract：:Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2015.12.013
更新日期：2016-01-12 00:00:00
abstract：:Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have been informed by stu...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2017.04.018
更新日期：2017-05-02 00:00:00
abstract：:Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and skeletal muscle, which shares a common progenitor with BAT, are dramatically decreased in mice placed on a high-fat diet and in obese humans. Expressio...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.11.005
更新日期：2012-12-05 00:00:00
abstract：:The polarization of adipose tissue-resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, the mechanisms controlling tissue macrophage activation remain unclear. Here we show that adipocytes are a source of Th2 cytokines, including I...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2008.04.002
更新日期：2008-06-01 00:00:00
abstract：:T cells promote inflammation in obesity, but how metabolic stress associated with obesity alters T cell responses remains unclear. In this issue of Cell Metabolism,Mauro et al. (2017) demonstrate that saturated fatty acids directly increase effector-memory T cell formation by amplifying T cell antigen-receptor-induced...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2017.02.012
更新日期：2017-03-07 00:00:00
abstract：:Genetic conservation allows ancient features of fat storage endocrine pathways to be explored in C. elegans. Multiple studies have used Nile red or BODIPY-labeled fatty acids to identify regulators of fat mass. When mixed with their food, E. coli bacteria, Nile red, and BODIPY-labeled fatty acids stain multiple spheri...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.10.002
更新日期：2009-11-01 00:00:00
abstract：:The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing ne...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2012.10.007
更新日期：2012-11-07 00:00:00
abstract：:Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Pemt(-/-) mice fed a choline-deficient (CD) diet develop rapid steatohepatitis ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.03.007
更新日期：2006-05-01 00:00:00
abstract：:The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mice, we show that βK...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.07.012
更新日期：2014-10-07 00:00:00
abstract：:Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD(+)) exhibits axon-protective effects in cultured neurons; however, its ability to block degeneration in vivo has been difficult to establish due to i...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.11.003
更新日期：2014-12-02 00:00:00
abstract：:Myriad strategies have been explored to compensate for the lack of dystrophin or to skip mutations that cause the lethal disease Duchenne muscular dystrophy (DMD). A new study shows that gene editing strategies used by bacteria can be applied in zygotes of a mouse model of DMD to correct the genetic defect that causes...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.11.011
更新日期：2014-12-02 00:00:00
abstract：:Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents was oxidized, cysteine-nitrosylated, and deplet...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2011.05.014
更新日期：2011-08-03 00:00:00
abstract：:Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired a...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2019.02.006
更新日期：2019-03-05 00:00:00
abstract：:Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2016.12.014
更新日期：2017-01-10 00:00:00
abstract：:The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here, we show that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues. In the inguinal depot, cold exposure resulted in elevated expression levels of brown-fat-ass...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2008.11.009
更新日期：2009-01-07 00:00:00
abstract：:We investigated relationships among immune, metabolic, and sleep abnormalities in mice with non-metastatic mammary cancer. Tumor-bearing mice displayed interleukin-6 (IL-6)-mediated peripheral inflammation, coincident with altered hepatic glucose processing and sleep. Tumor-bearing mice were hyperphagic, had reduced s...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.04.021
更新日期：2018-07-03 00:00:00
abstract：:Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However, how cold activates type 2 immunity in WAT remains obscure. Here we show that cold-induced type 2 immune responses and beiging in subcutaneous WAT (scWAT) are abro...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.08.003
更新日期：2017-09-05 00:00:00
abstract：:The biogenesis and function of the mitochondrial respiratory chain (RC) involve the organization of RC enzyme complexes in supercomplexes or respirasomes through an unknown biosynthetic process. This leads to structural interdependences between RC complexes, which are highly relevant from biological and biomedical per...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.01.015
更新日期：2012-03-07 00:00:00
abstract：:TRPM channels have emerged as key mediators of diverse physiological functions. However, the ionic permeability relevant to physiological function in vivo remains unclear for most members. We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) an...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.08.012
更新日期：2010-10-06 00:00:00
abstract：:Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not expres...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2011.03.016
更新日期：2011-05-04 00:00:00
abstract：:What are the pathways that underlie the coordinated responses of an organism to well-fed and food-deprived states? A report in this issue of Cell Metabolism suggests that starvation functions via a muscarinic acetylcholine receptor to activate MAP kinase signaling in the pharyngeal muscle of C. elegans (You et al., 20...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2006.03.002
更新日期：2006-04-01 00:00:00
