Lipotoxicity, β cell dysfunction, and gestational diabetes.

Abstract:

:Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Nolan CJ

doi

10.1016/j.cmet.2014.03.020

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

553-4

issue

4

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(14)00125-9

journal_volume

19

pub_type

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