Enriching the Circadian Proteome.

Abstract:

:Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of the nuclear and phosphoproteome.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Takahashi JS

doi

10.1016/j.cmet.2016.12.014

subject

Has Abstract

pub_date

2017-01-10 00:00:00

pages

1-2

issue

1

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(16)30647-7

journal_volume

25

pub_type

评论,杂志文章
  • Enhancing hepatic glycolysis reduces obesity: differential effects on lipogenesis depend on site of glycolytic modulation.

    abstract::Reducing obesity requires an elevation of energy expenditure and/or a suppression of food intake. Here we show that enhancing hepatic glycolysis reduces body weight and adiposity in obese mice. Overexpression of glucokinase or 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is used to increase hepatic glycolysis....

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2005.07.003

    authors: Wu C,Kang JE,Peng LJ,Li H,Khan SA,Hillard CJ,Okar DA,Lange AJ

    更新日期:2005-08-01 00:00:00

  • Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments.

    abstract::Over the past years, plenty of evidence has emerged illustrating how metabolism supports many aspects of cellular function and how metabolic reprogramming can drive cell differentiation and fate. Here, we present a method to assess the metabolic configuration of single cells within their native tissue microenvironment...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.08.014

    authors: Miller A,Nagy C,Knapp B,Laengle J,Ponweiser E,Groeger M,Starkl P,Bergmann M,Wagner O,Haschemi A

    更新日期:2017-11-07 00:00:00

  • A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition.

    abstract::Insulin rapidly suppresses hepatic glucose production and slowly decreases expression of genes encoding gluconeogenic proteins. In this study, we show that an immediate effect of insulin is to redirect newly synthesized glucose-6-phosphate to glycogen without changing the rate of gluconeogenesis. This process requires...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2013.06.001

    authors: Wan M,Leavens KF,Hunter RW,Koren S,von Wilamowitz-Moellendorff A,Lu M,Satapati S,Chu Q,Sakamoto K,Burgess SC,Birnbaum MJ

    更新日期:2013-07-02 00:00:00

  • Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.

    abstract::Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 mon...

    journal_title:Cell metabolism

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.cmet.2016.11.004

    authors: Greggio C,Jha P,Kulkarni SS,Lagarrigue S,Broskey NT,Boutant M,Wang X,Conde Alonso S,Ofori E,Auwerx J,Cantó C,Amati F

    更新日期:2017-02-07 00:00:00

  • Surprising New Players in Glia-Neuron Crosstalk: Role in CNS Regeneration.

    abstract::Glia-neuron interactions underlie a number of homeostatic processes in the brain. In this issue of Cell Metabolism, Li et al. (2020) demonstrate that the regeneration of central nervous system axons is accelerated through modulation of neuronal GABA-B receptor activity by metabolic energy intermediaries released from ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.10.009

    authors: Morrison BM

    更新日期:2020-11-03 00:00:00

  • Pro- versus Anti-inflammatory Actions of HDLs in Innate Immunity.

    abstract::High-density lipoproteins (HDLs) can inhibit inflammatory cytokine expression on innate immune cells, but sometimes they promote cytokine production as suggested in a recent article in Cell Metabolism by van der Vorst et al. (2017). Kopecky et al. point out that the origin, handling, and storage conditions of HDL prep...

    journal_title:Cell metabolism

    pub_type: 信件

    doi:10.1016/j.cmet.2017.04.007

    authors: Kopecky C,Michlits G,Säemann MD,Weichhart T

    更新日期:2017-07-05 00:00:00

  • How is the hungry brain like a sieve?

    abstract::Whether some hypothalamic neurons have direct access to circulating metabolic cues represents a crucial question that has been intensely debated. New findings reveal that fasting promotes "leakiness" of some hypothalamic blood vessels, increasing the access of circulating factors to certain hypothalamic neurons that c...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2013.03.007

    authors: Myers MG Jr

    更新日期:2013-04-02 00:00:00

  • TOR regulation: sorting out the answers.

    abstract::Components involved in vesicle trafficking processes such as secretion, endocytosis, and autophagy are gaining recognition as important regulators and effectors of target of rapamycin (TOR) signaling. A recent report by now implicates Pmr1, a secretory pathway Ca(2+)/Mn(2+) ATPase located in the Golgi apparatus, as a ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2006.12.008

    authors: Neufeld TP

    更新日期:2007-01-01 00:00:00

  • Moving beyond GWAS and eQTL Analysis to Validated Hits in Chronic Kidney Disease.

    abstract::Genome-wide association studies (GWAS) have identified multiple chronic kidney disease (CKD)-associated single-nucleotide polymorphisms (SNPs) mainly localized to non-coding genomic regions. To understand which genes and which cell types are affected by these genetic variants, compartment-specific transcriptome, genom...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2018.12.009

    authors: Müller-Deile J,Jobst-Schwan T,Schiffer M

    更新日期:2019-01-08 00:00:00

  • DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and me...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2013.07.004

    authors: Ahrens M,Ammerpohl O,von Schönfels W,Kolarova J,Bens S,Itzel T,Teufel A,Herrmann A,Brosch M,Hinrichsen H,Erhart W,Egberts J,Sipos B,Schreiber S,Häsler R,Stickel F,Becker T,Krawczak M,Röcken C,Siebert R,Schafmayer

    更新日期:2013-08-06 00:00:00

  • Getting a "Hold" on NPC2.

    abstract::Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through wh...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2009.08.006

    authors: Ory DS

    更新日期:2009-09-01 00:00:00

  • mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc.

    abstract::Aerobic glycolysis (the Warburg effect) is a core hallmark of cancer, but the molecular mechanisms underlying it remain unclear. Here, we identify an unexpected central role for mTORC2 in cancer metabolic reprogramming where it controls glycolytic metabolism by ultimately regulating the cellular level of c-Myc. We sho...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2013.09.013

    authors: Masui K,Tanaka K,Akhavan D,Babic I,Gini B,Matsutani T,Iwanami A,Liu F,Villa GR,Gu Y,Campos C,Zhu S,Yang H,Yong WH,Cloughesy TF,Mellinghoff IK,Cavenee WK,Shaw RJ,Mischel PS

    更新日期:2013-11-05 00:00:00

  • The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle.

    abstract::Nuclear receptor signaling plays an important role in energy metabolism. In this study we demonstrate that the nuclear receptor corepressor RIP140 is a key regulator of metabolism in skeletal muscle. RIP140 is expressed in a fiber type-specific manner, and manipulation of its levels in null, heterozygous, and transgen...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2007.08.004

    authors: Seth A,Steel JH,Nichol D,Pocock V,Kumaran MK,Fritah A,Mobberley M,Ryder TA,Rowlerson A,Scott J,Poutanen M,White R,Parker M

    更新日期:2007-09-01 00:00:00

  • Transgenerational inheritance of longevity: epigenetic mysteries abound.

    abstract::Transgenerational inheritance of epigenetic characteristics in plants has been reported, whereas nongenetic persistence of complex phenotypes in animals is controversial. A recent report by Anne Brunet and colleagues describes a fascinating example of persistence across generations of extended life span in worm and ex...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2011.12.012

    authors: Berger SL

    更新日期:2012-01-04 00:00:00

  • Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain.

    abstract::High-fat diets cause peripheral leptin resistance, and dietary lipid composition affects sensitivity to leptin. We examined the role of n-3 polyunsaturated fatty acid (PUFA) in peripheral leptin resistance. Dietary PUFAs (0.4% wt/wt) caused insensitivity to peripherally but not intracerebroventricularly administered l...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2005.04.004

    authors: Oh-I S,Shimizu H,Sato T,Uehara Y,Okada S,Mori M

    更新日期:2005-05-01 00:00:00

  • Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.

    abstract::Mammary epithelial cells transition between periods of proliferation and quiescence during development, menstrual cycles, and pregnancy, and as a result of oncogenic transformation. Utilizing an organotypic 3D tissue culture model coupled with quantitative metabolomics and proteomics, we identified significant differe...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.03.016

    authors: Coloff JL,Murphy JP,Braun CR,Harris IS,Shelton LM,Kami K,Gygi SP,Selfors LM,Brugge JS

    更新日期:2016-05-10 00:00:00

  • Ancillary Activity: Beyond Core Metabolism in Immune Cells.

    abstract::Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2017.06.019

    authors: Puleston DJ,Villa M,Pearce EL

    更新日期:2017-07-05 00:00:00

  • Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation.

    abstract::The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.02.012

    authors: Abraham RT

    更新日期:2016-03-08 00:00:00

  • Physiological and Molecular Dissection of Daily Variance in Exercise Capacity.

    abstract::Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity betwee...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.03.012

    authors: Ezagouri S,Zwighaft Z,Sobel J,Baillieul S,Doutreleau S,Ladeuix B,Golik M,Verges S,Asher G

    更新日期:2019-07-02 00:00:00

  • Hypoxia-independent angiogenesis in adipose tissues during cold acclimation.

    abstract::The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here, we show that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues. In the inguinal depot, cold exposure resulted in elevated expression levels of brown-fat-ass...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2008.11.009

    authors: Xue Y,Petrovic N,Cao R,Larsson O,Lim S,Chen S,Feldmann HM,Liang Z,Zhu Z,Nedergaard J,Cannon B,Cao Y

    更新日期:2009-01-07 00:00:00

  • Break on Through: Golgi-Derived Vesicles Aid in Mitochondrial Fission.

    abstract::Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, iden...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.05.010

    authors: Rasmussen ML,Robertson GL,Gama V

    更新日期:2020-06-02 00:00:00

  • Macrophage autophagy plays a protective role in advanced atherosclerosis.

    abstract::In advanced atherosclerosis, macrophage apoptosis coupled with defective phagocytic clearance of the apoptotic cells (efferocytosis) promotes plaque necrosis, which precipitates acute atherothrombotic cardiovascular events. Oxidative and endoplasmic reticulum (ER) stress in macrophages are important causes of advanced...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2012.01.022

    authors: Liao X,Sluimer JC,Wang Y,Subramanian M,Brown K,Pattison JS,Robbins J,Martinez J,Tabas I

    更新日期:2012-04-04 00:00:00

  • Identification of a protein mediating respiratory supercomplex stability.

    abstract::The complexes of the electron transport chain associate into large macromolecular assemblies, which are believed to facilitate efficient electron flow. We have identified a conserved mitochondrial protein, named respiratory supercomplex factor 1 (Rcf1-Yml030w), that is required for the normal assembly of respiratory s...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2012.02.006

    authors: Chen YC,Taylor EB,Dephoure N,Heo JM,Tonhato A,Papandreou I,Nath N,Denko NC,Gygi SP,Rutter J

    更新日期:2012-03-07 00:00:00

  • Conserved metabolic regulatory functions of sirtuins.

    abstract::Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2007.11.006

    authors: Schwer B,Verdin E

    更新日期:2008-02-01 00:00:00

  • The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis.

    abstract::Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Pemt(-/-) mice fed a choline-deficient (CD) diet develop rapid steatohepatitis ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2006.03.007

    authors: Li Z,Agellon LB,Allen TM,Umeda M,Jewell L,Mason A,Vance DE

    更新日期:2006-05-01 00:00:00

  • Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State.

    abstract::Understanding the neural framework behind appetite control is fundamental to developing effective therapies to combat the obesity epidemic. The paraventricular hypothalamus (PVH) is critical for appetite regulation, yet, the real-time, physiological response properties of PVH neurons to nutrients are unknown. Using a ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.10.016

    authors: Li C,Navarrete J,Liang-Guallpa J,Lu C,Funderburk SC,Chang RB,Liberles SD,Olson DP,Krashes MJ

    更新日期:2019-03-05 00:00:00

  • Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step.

    abstract::A hypothesis that accounts for most of the available literature on insulin-stimulated GLUT4 translocation is that insulin action controls the access of GLUT4 vesicles to a constitutively active plasma-membrane fusion process. However, using an in vitro fusion assay, we show here that fusion is not constitutively activ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2005.08.007

    authors: Koumanov F,Jin B,Yang J,Holman GD

    更新日期:2005-09-01 00:00:00

  • Energy intake and exercise as determinants of brain health and vulnerability to injury and disease.

    abstract::Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be optimized by intermittent dietary energy restriction (ER) and exercise. Such energetic challenges engage adaptive cellular stress-response signaling pathways in neu...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2012.08.012

    authors: Mattson MP

    更新日期:2012-12-05 00:00:00

  • Single-Cell RNA-Seq of the Pancreatic Islets--a Promise Not yet Fulfilled?

    abstract::In the past 3 years, we have seen a flurry of publications on single-cell RNA sequencing (RNA-seq) analyses of pancreatic islets from mouse and human. This technology holds the promise to refine cell-type signatures and discover cellular heterogeneity among the canonical endocrine cell types such as the glucagon-produ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2018.11.016

    authors: Wang YJ,Kaestner KH

    更新日期:2019-03-05 00:00:00

  • Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.

    abstract::The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic ...

    journal_title:Cell metabolism

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.cmet.2017.02.009

    authors: Robinson MM,Dasari S,Konopka AR,Johnson ML,Manjunatha S,Esponda RR,Carter RE,Lanza IR,Nair KS

    更新日期:2017-03-07 00:00:00