Abstract：
:Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure. Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if lipolysis is important for future body weight gain and associated disturbed glucose metabolism, and this was presently investigated in subcutaneous adipocytes from two female cohorts before and after ≥10-year follow-up. High basal and low stimulated lipolysis at baseline predicted future weight gain (odds ratios ≥4.6) as well as development of insulin resistance and impaired fasting glucose/type 2 diabetes (odds ratios ≥3.2). At baseline, weight gainers displayed lower adipose expression of several established lipolysis-regulating genes. Thus, inefficient lipolysis (high basal/low stimulated) involving altered gene expression is linked to future weight gain and impaired glucose metabolism and may constitute a treatment target. Finally, low stimulated lipolysis could be accurately estimated in vivo by simple clinical/biochemical measures and may be used to identify risk individuals for intensified preventive measures.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Arner P,Andersson DP,Bäckdahl J,Dahlman I,Rydén Mdoi
10.1016/j.cmet.2018.05.004subject
Has Abstractpub_date
2018-07-03 00:00:00pages
45-54.e3issue
1eissn
1550-4131issn
1932-7420pii
S1550-4131(18)30311-5journal_volume
28pub_type
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