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Insulin resistance in the defense against obesity.

Abstract：

:In the face of the current obesity epidemic, the nature of the relationship between overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state of excessive insulin action that elicits a series of cellular homeostatic responses, producing systemic insulin resistance. These responses occur in four steps: homologous desensitization to insulin action, leptin secretion, inflammation, and, finally, a counter-inflammatory phase that serves to conserve energy storage. The molecular mechanisms underlying these steps are discussed in the context of potential new therapeutic approaches.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Saltiel AR

doi

10.1016/j.cmet.2012.03.001

subject

Has Abstract

pub_date

2012-06-06 00:00:00

pages

798-804

issue

6

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(12)00095-2

journal_volume

15

pub_type

杂志文章

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