Abstract：
:Plasticity in growth and reproductive behavior is found in many vertebrate species, but is common in male teleost fish. Typically, "bourgeois" males are considerably larger and defend breeding territories while "parasitic" variants are small and use opportunistic breeding strategies. The P locus mediates this phenotypic variation in Xiphophorus and encodes variant alleles of the melanocortin-4 receptor (MC4R). However, deletion of the MC4R has modest effects on somatic growth and reproduction in mammals, suggesting a fundamental difference in the neuroendocrine function of central melanocortin signaling in teleosts. Here we show in a teleost that the hypothalamic pro-opiomelanocortin and AgRP neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones. Indeed, AgRP-mediated suppression of MC4R appears essential for early larval growth. This identifies the mechanism by which the central melanocortin system coordinately regulates growth and reproduction in teleosts and suggests it is an important anatomical substrate for evolutionary adaptation.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Zhang C,Forlano PM,Cone RDdoi
10.1016/j.cmet.2011.12.014subject
Has Abstractpub_date
2012-02-08 00:00:00pages
256-64issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(11)00497-9journal_volume
15pub_type
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