Abstract：
:Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates the metabolic enzyme acetyl-coenzyme A (acetyl-CoA) synthetase. The earliest function of sirtuins therefore may have been regulation of cellular metabolism in response to nutrient availability. Recent findings support the idea that sirtuins play a pivotal role in metabolic control in higher organisms, including mammals. This review surveys evidence for an emerging role of sirtuins as regulators of metabolism in mammals.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Schwer B,Verdin Edoi
10.1016/j.cmet.2007.11.006subject
Has Abstractpub_date
2008-02-01 00:00:00pages
104-12issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(07)00341-5journal_volume
7pub_type
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