Metabolic switches linked to pluripotency and embryonic stem cell differentiation.

Abstract:

:Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Shyh-Chang N,Daley GQ

doi

10.1016/j.cmet.2015.02.011

subject

Has Abstract

pub_date

2015-03-03 00:00:00

pages

349-50

issue

3

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(15)00063-7

journal_volume

21

pub_type

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