Abstract：
:Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC) and other regions in the brainstem. Consistent with this, Arc NPY signaling decreased sympathetically innervated BAT thermogenesis, involving the downregulation of uncoupling protein 1 (UCP1) expression in BAT. Taken together, these data reveal a powerful Arc-NPY-regulated neuronal circuit that controls BAT thermogenesis and sympathetic output via TH neurons.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Shi YC,Lau J,Lin Z,Zhang H,Zhai L,Sperk G,Heilbronn R,Mietzsch M,Weger S,Huang XF,Enriquez RF,Baldock PA,Zhang L,Sainsbury A,Herzog H,Lin Sdoi
10.1016/j.cmet.2013.01.006subject
Has Abstractpub_date
2013-02-05 00:00:00pages
236-48issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(13)00014-4journal_volume
17pub_type
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