Abstract:
:Cholesteryl ester accumulation by macrophages is a critical early event in atherogenesis. To test the hypothesis that sterol loading promotes foam cell formation and vascular disease by perturbing a network of interacting proteins, we used a global approach to identify proteins that are differentially expressed when macrophages are loaded with cholesterol in vivo. Our analysis revealed a sterol-responsive network that is highly enriched in proteins with known physical interactions, established roles in vesicular transport, and demonstrated atherosclerotic phenotypes in mice. Pharmacologic intervention with a statin or rosiglitazone and use of mice deficient in LDL receptor or apolipoprotein E implicated the network in atherosclerosis. Biochemical fractionation revealed that most of the sterol-responsive proteins resided in microvesicles, providing a physical basis for the network's functional and biochemical properties. These observations identify a highly integrated network of proteins whose expression is influenced by environmental, genetic, and pharmacological factors implicated in atherogenesis.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Becker L,Gharib SA,Irwin AD,Wijsman E,Vaisar T,Oram JF,Heinecke JWdoi
10.1016/j.cmet.2010.01.003subject
Has Abstractpub_date
2010-02-03 00:00:00pages
125-35issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(10)00004-5journal_volume
11pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract::Glia-neuron interactions underlie a number of homeostatic processes in the brain. In this issue of Cell Metabolism, Li et al. (2020) demonstrate that the regeneration of central nervous system axons is accelerated through modulation of neuronal GABA-B receptor activity by metabolic energy intermediaries released from ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.10.009
更新日期:2020-11-03 00:00:00
abstract::Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD(+) biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in mammals. However, the significance of eNAMPT secretion remains unclear. Here we demonstrate that deacetylation of iNAMPT by the mammalian NAD(+)-dependent deacet...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.04.002
更新日期:2015-05-05 00:00:00
abstract::Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and c...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.10.005
更新日期:2007-11-01 00:00:00
abstract::Circadian clocks, which underlie the daily rhythms in virtually all organisms, are entrained by diurnal changes in light, temperature, nutrients, and even sound. Simoni et al. (2014) demonstrate that diurnal variation in mechanical vibrations can reset circadian clock phase, providing a potential mechanism for integra...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2014.04.011
更新日期:2014-05-06 00:00:00
abstract::You are what you eat; but when you eat also seems to be important for a healthy metabolism. In this issue of Cell Metabolism, Benegiamo et al. (2018) uncover a mechanism by which the RNA-binding protein NONO promotes the time-of-day-dependent expression of key metabolic genes at a post-transcriptional level in respons...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2018.01.009
更新日期:2018-02-06 00:00:00
abstract::Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlatio...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.04.012
更新日期:2020-05-05 00:00:00
abstract::Impaired angiogenesis has been implicated in adipose tissue dysfunction and the development of obesity and associated metabolic disorders. Here, we report the unexpected finding that vascular endothelial growth factor B (VEGFB) gene transduction into mice inhibits obesity-associated inflammation and improves metabolic...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.03.004
更新日期:2016-04-12 00:00:00
abstract::Nuclear receptor signaling plays an important role in energy metabolism. In this study we demonstrate that the nuclear receptor corepressor RIP140 is a key regulator of metabolism in skeletal muscle. RIP140 is expressed in a fiber type-specific manner, and manipulation of its levels in null, heterozygous, and transgen...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.08.004
更新日期:2007-09-01 00:00:00
abstract::Repression of mitochondrial respiration represents an evolutionarily ancient cellular adaptation to hypoxia and profoundly influences cell survival and function; however, the underlying molecular mechanisms are incompletely understood. Primarily utilizing pulmonary arterial endothelial cells as a representative hypoxi...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.08.015
更新日期:2009-10-01 00:00:00
abstract::The fibroblast growth factor receptor 4 (FGFR4)-R388 single-nucleotide polymorphism has been associated with cancer risk and prognosis. Here we show that the FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3/5 signaling. This STAT activation transcriptionally induces Grb14 in pancreatic en...
journal_title:Cell metabolism
pub_type: 杂志文章,收录出版
doi:10.1016/j.cmet.2013.05.002
更新日期:2013-06-04 00:00:00
abstract::Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the contr...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.01.006
更新日期:2013-02-05 00:00:00
abstract::Reducing obesity requires an elevation of energy expenditure and/or a suppression of food intake. Here we show that enhancing hepatic glycolysis reduces body weight and adiposity in obese mice. Overexpression of glucokinase or 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is used to increase hepatic glycolysis....
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2005.07.003
更新日期:2005-08-01 00:00:00
abstract::Over the past years, plenty of evidence has emerged illustrating how metabolism supports many aspects of cellular function and how metabolic reprogramming can drive cell differentiation and fate. Here, we present a method to assess the metabolic configuration of single cells within their native tissue microenvironment...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2017.08.014
更新日期:2017-11-07 00:00:00
abstract::Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycer...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2008.02.002
更新日期:2008-03-01 00:00:00
abstract::Obese adipose tissue is characterized by infiltration of macrophages. We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue. This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-asso...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.08.015
更新日期:2008-10-01 00:00:00
abstract::Metabolic reprogramming plays an important role in supporting tumor growth. However, little is known about the metabolic alterations that promote cancer metastasis. In this study, we identify acyl-CoA thioesterase 12 (ACOT12) as a key player in hepatocellular carcinoma (HCC) metastasis. The expression of ACOT12 is sig...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.12.019
更新日期:2019-04-02 00:00:00
abstract::Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.12.013
更新日期:2016-01-12 00:00:00
abstract::Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be optimized by intermittent dietary energy restriction (ER) and exercise. Such energetic challenges engage adaptive cellular stress-response signaling pathways in neu...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2012.08.012
更新日期:2012-12-05 00:00:00
abstract::Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.03.006
更新日期:2008-05-01 00:00:00
abstract::The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.02.004
更新日期:2010-03-03 00:00:00
abstract::The trace element copper (Cu) is a cofactor for biochemical functions ranging from energy generation to iron (Fe) acquisition, angiogenesis, and free radical detoxification. While Cu is essential for life, the molecules that mediate dietary Cu uptake have not been identified. Ctr1 is a homotrimeric protein, conserved ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2006.08.009
更新日期:2006-09-01 00:00:00
abstract::AMPK is a kinase involved in cell energy homeostasis. In this issue of Cell Metabolism, Chopra and colleagues (2011) reveal a new function of AMPK in stimulating fat absorption. AMPK enhances the expression of the bile acid transporter, BSEP, by activating the coactivator SRC-2, thus promoting bile acid secretion. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2010.12.009
更新日期:2011-01-05 00:00:00
abstract::The final steps in the production of adenosine triphosphate (ATP) in mitochondria are executed by a series of multisubunit complexes and electron carriers, which together constitute the oxidative phosphorylation (OXPHOS) system. OXPHOS is under dual genetic control, with communication between the nuclear and mitochond...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2005.12.001
更新日期:2006-01-01 00:00:00
abstract::Bile acid metabolism is tightly controlled due to the toxic effects of bile acid overload. In this issue, research from the Feng lab reports Shp2 as a novel integrator of hepatic bile acid and FGF15/FGF19 signaling, adding another layer of complexity to the control of bile acid biosynthesis. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2014.07.019
更新日期:2014-08-05 00:00:00
abstract::Glucagon drives hepatic gluconeogenesis and maintains blood glucose levels during fasting. The mechanism that attenuates glucagon action following refeeding is not understood. The present study demonstrates an increase in perivenous liver hypoxia immediately after feeding, which stabilizes hypoxia-inducible factor 2α ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.01.004
更新日期:2016-03-08 00:00:00
abstract::Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2007.11.006
更新日期:2008-02-01 00:00:00
abstract::Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic signaling molecule involved in cardiovascular and metabolic regulation. More recently, an alternative pathway for the formation of this free radical has been explored. The inorganic anions nitrate (NO3-) and nitrite (NO2-), origi...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2018.06.007
更新日期:2018-07-03 00:00:00
abstract::Aging is driven by changes of the epigenetic state that are only partially understood. We performed a comprehensive epigenomic analysis of the pancreatic β cell, key player in glucose homeostasis, in adolescent and very old mice. We observe a global methylation drift resulting in an overall more leveled methylome in o...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.07.025
更新日期:2015-10-06 00:00:00
abstract::Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containin...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.04.023
更新日期:2015-05-05 00:00:00
abstract::Zika virus is a pathogen that poses serious consequences, including congenital microcephaly. Although many viruses reprogram host cell metabolism, whether Zika virus alters cellular metabolism and the functional consequences of Zika-induced metabolic changes remain unknown. Here, we show that Zika virus infection diff...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.01.024
更新日期:2019-05-07 00:00:00