解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::CD147 is a tumor-associated glycoprotein that regulates cell metabolism. However, CD147 methylation and its subsequent role in cancer cell metabolism remain unclear. Here, we detect CD147 di-methylation in 16 non-small-cell lung cancer (NSCLC) tissues using liquid chromatography-tandem mass spectrometry. CD147 is di-m...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.12.010
更新日期:2021-01-05 00:00:00
abstract::It is still unclear if the ability of key regulators of actin cytoskeletal remodeling to influence lipid metabolism contributes to kidney injury. In this issue of Cell Metabolism, Fu et al. (2020) show that junctional adhesion molecule-like (JAML) is a novel mediator of glomerular disease progression while suggesting ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.11.002
更新日期:2020-12-01 00:00:00
abstract::Glia-neuron interactions underlie a number of homeostatic processes in the brain. In this issue of Cell Metabolism, Li et al. (2020) demonstrate that the regeneration of central nervous system axons is accelerated through modulation of neuronal GABA-B receptor activity by metabolic energy intermediaries released from ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.10.009
更新日期:2020-11-03 00:00:00
abstract::Mammalian organs are nourished by nutrients carried by the blood circulation. These nutrients originate from diet and internal stores, and can undergo various interconversions before their eventual use as tissue fuel. Here we develop isotope tracing, mass spectrometry, and mathematical analysis methods to determine th...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.07.013
更新日期:2020-10-06 00:00:00
abstract::In this issue of the Cell Metabolism, Chevalier et al. show that a warm environment produces changes in the composition of intestinal microbiota and that these changes can prevent bone loss due to hypogonadism. Dovetailing with prior studies on the ability of probiotics to reverse hypogonadism-induced osteopenia, the ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.09.010
更新日期:2020-10-06 00:00:00
abstract::Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes in the gut microbiota appear to be important. The inhibitory role of mic...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.07.012
更新日期:2020-10-06 00:00:00
abstract::Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alpha-ketoglutarate (delivered in the form of a calcium salt, CaAKG) on healthspan and lifespan in C57BL...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.08.004
更新日期:2020-09-01 00:00:00
abstract::Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, iden...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.05.010
更新日期:2020-06-02 00:00:00
abstract::Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlatio...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.04.012
更新日期:2020-05-05 00:00:00
abstract::Postprandial hypoglycemia is a disabling complication of the treatment of obesity by gastric bypass surgery. So far, no therapy exists, and the underlying mechanisms remain unclear. Here, we hypothesized that glucose-induced IL-1β leads to an exaggerated insulin response in this condition. Therefore, we conducted a pl...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.02.013
更新日期:2020-04-07 00:00:00
abstract::In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.03.012
更新日期:2020-04-07 00:00:00
abstract::Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.02.012
更新日期:2020-04-07 00:00:00
abstract::The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are interlinked, opposing signaling pathways involved in sensing availability of nutrients and energy and regulation of cell growth. AMPK (Yin, or the "dark side") is switched on by lack of energy or nutrients and inhibits cell growth, whil...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2020.01.015
更新日期:2020-03-03 00:00:00
abstract::Regulatory T cells (Tregs) subdue immune responses. Central to Treg activation are changes in lipid metabolism that support their survival and function. Fatty acid binding proteins (FABPs) are a family of lipid chaperones required to facilitate uptake and intracellular lipid trafficking. One family member, FABP5, is e...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.11.021
更新日期:2020-02-04 00:00:00
abstract::To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists. Similarly, activating CalcrNTS neurons decre...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.12.012
更新日期:2020-02-04 00:00:00
abstract::Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of MRI, though its ability to inform on relevant changes to biochemistry in humans remains unclear. In this work, we image pyruvate metabolism in patients, assessing the reproducibility of delivery and conversion in the setting of p...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.08.024
更新日期:2020-01-07 00:00:00
abstract::Microglia play a crucial role in immune responses, including inflammation. Diet-induced obesity (DIO) triggers microglia activation and hypothalamic inflammation as early as 3 days after high-fat diet (HFD) exposure, before changes in body weight occur. The intracellular mechanism(s) responsible for HFD-induced microg...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.08.010
更新日期:2019-11-05 00:00:00
abstract::Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key componen...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.10.010
更新日期:2019-11-05 00:00:00
abstract::Cancer cells that leave their natural environment during metastatic spread must adapt to numerous stresses to survive. In this issue, Labuschagne et al. (2019) highlight one adaptive mechanism to overcome these stresses that involves cell clustering, which induces a hypoxic environment and metabolic rewiring to buffer...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.09.008
更新日期:2019-10-01 00:00:00
abstract::miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression and the function of...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2019.07.011
更新日期:2019-10-01 00:00:00
abstract::Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with am...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.08.017
更新日期:2019-09-03 00:00:00
abstract::The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2019.06.019
更新日期:2019-08-06 00:00:00
abstract::Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lip...
journal_title:Cell metabolism
pub_type: 信件
doi:10.1016/j.cmet.2019.05.014
更新日期:2019-07-02 00:00:00
abstract::We caught up with some of the leading researchers in the NAD+ metabolism and signaling field as they gathered in Dublin for the 2019 FASEB Science Research Conference. Here they share their excitement from the rich history of NAD+ biology dating back over 100 years ago to a future of translation benefiting human healt...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.06.013
更新日期:2019-07-02 00:00:00
abstract::Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity betwee...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.03.012
更新日期:2019-07-02 00:00:00
abstract::The basis for region-specific neuronal toxicity in Huntington disease is unknown. Here, we show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes. Glucose is low in HdhQ(150/150) animals, and astrocytes in each brain region adapt by metabolically reprogramming their mitochondria ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.03.004
更新日期:2019-06-04 00:00:00
abstract::In this issue of Cell Metabolism, Du et al. (2019) describe how insulin-like growth factor 2 (IGF-2), a protein with structural similarity to insulin, induces an anti-inflammatory phenotype in maturing macrophages through reprogramming of their mitochondrial metabolism. These anti-inflammatory properties are maintaine...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.05.012
更新日期:2019-06-04 00:00:00
abstract::Zika virus is a pathogen that poses serious consequences, including congenital microcephaly. Although many viruses reprogram host cell metabolism, whether Zika virus alters cellular metabolism and the functional consequences of Zika-induced metabolic changes remain unknown. Here, we show that Zika virus infection diff...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.01.024
更新日期:2019-05-07 00:00:00
abstract::Metabolic reprogramming plays an important role in supporting tumor growth. However, little is known about the metabolic alterations that promote cancer metastasis. In this study, we identify acyl-CoA thioesterase 12 (ACOT12) as a key player in hepatocellular carcinoma (HCC) metastasis. The expression of ACOT12 is sig...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.12.019
更新日期:2019-04-02 00:00:00
abstract::The isolation and biochemical characterization of lipid droplet (LD)-associated mitochondria revealed the capacity of the cell to produce and maintain distinct mitochondrial populations carrying disparate proteome and dissimilar capacities to oxidize fatty acids and pyruvate. With mitochondrial motility being a centra...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2019.02.011
更新日期:2019-04-02 00:00:00
abstract::Mitochondria are dynamic organelles that have been linked to stem cell homeostasis. However, the mechanisms involved in mitochondrial regulation of stem cell fate determination remain elusive. Here we discover that epithelial-mesenchymal transition (EMT), a key process in cancer progression, induces mitochondrial fusi...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.11.004
更新日期:2019-04-02 00:00:00
abstract::delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids. In this issue, Kim et al. (2019) show that production of NAD+ by this desaturase reaction is an adaptive response to NAD+ depletion that may regulate cellular REDOX status. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.03.007
更新日期:2019-04-02 00:00:00
abstract::In the past 3 years, we have seen a flurry of publications on single-cell RNA sequencing (RNA-seq) analyses of pancreatic islets from mouse and human. This technology holds the promise to refine cell-type signatures and discover cellular heterogeneity among the canonical endocrine cell types such as the glucagon-produ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2018.11.016
更新日期:2019-03-05 00:00:00
abstract::Understanding the neural framework behind appetite control is fundamental to developing effective therapies to combat the obesity epidemic. The paraventricular hypothalamus (PVH) is critical for appetite regulation, yet, the real-time, physiological response properties of PVH neurons to nutrients are unknown. Using a ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.10.016
更新日期:2019-03-05 00:00:00
abstract::The interaction between the immune system and endocrine cells in the pancreas is crucial for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) enables multiplexed assessment of the abundance and localization of more than 30 proteins on the same tissue section at 1-μm resolution. Her...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.01.003
更新日期:2019-03-05 00:00:00
abstract::Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired a...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.02.006
更新日期:2019-03-05 00:00:00
abstract::The conversion of lipolysis-derived fatty acids into ketone bodies (ketogenesis) is a crucial metabolic adaptation to prolonged periods of food scarcity. The process occurs primarily in liver mitochondria and is initiated by fatty-acid-mediated stimulation of the ligand-operated transcription factor, peroxisome prolif...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.09.014
更新日期:2019-01-08 00:00:00
abstract::Genome-wide association studies (GWAS) have identified multiple chronic kidney disease (CKD)-associated single-nucleotide polymorphisms (SNPs) mainly localized to non-coding genomic regions. To understand which genes and which cell types are affected by these genetic variants, compartment-specific transcriptome, genom...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2018.12.009
更新日期:2019-01-08 00:00:00
abstract::Reporting in Cell Metabolism, Pflimlin et al. recently found no beneficial effect of PAHSAs on glucose control in mice on several high-fat diets. Kuda cautions that due to methodological differences, the data must be carefully reinterpreted, emphasizing that olive oil contains high amounts of FAHFAs, potentially maski...
journal_title:Cell metabolism
pub_type: 评论,信件
doi:10.1016/j.cmet.2018.09.006
更新日期:2018-10-02 00:00:00
abstract::Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.05.022
更新日期:2018-08-07 00:00:00