听力与言语-语言病理学

行为科学

医学伦理学

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  • Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.

    abstract::CD147 is a tumor-associated glycoprotein that regulates cell metabolism. However, CD147 methylation and its subsequent role in cancer cell metabolism remain unclear. Here, we detect CD147 di-methylation in 16 non-small-cell lung cancer (NSCLC) tissues using liquid chromatography-tandem mass spectrometry. CD147 is di-m...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.12.010

    authors: Wang K,Huang W,Chen R,Lin P,Zhang T,Ni YF,Li H,Wu J,Sun XX,Geng JJ,Zhu YM,Nan G,Zhang W,Chen X,Zhu P,Bian H,Chen ZN

    更新日期:2021-01-05 00:00:00

  • Lipid Metabolism Gets in a JAML during Kidney Disease.

    abstract::It is still unclear if the ability of key regulators of actin cytoskeletal remodeling to influence lipid metabolism contributes to kidney injury. In this issue of Cell Metabolism, Fu et al. (2020) show that junctional adhesion molecule-like (JAML) is a novel mediator of glomerular disease progression while suggesting ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.11.002

    authors: Fornoni A,Merscher S

    更新日期:2020-12-01 00:00:00

  • Surprising New Players in Glia-Neuron Crosstalk: Role in CNS Regeneration.

    abstract::Glia-neuron interactions underlie a number of homeostatic processes in the brain. In this issue of Cell Metabolism, Li et al. (2020) demonstrate that the regeneration of central nervous system axons is accelerated through modulation of neuronal GABA-B receptor activity by metabolic energy intermediaries released from ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.10.009

    authors: Morrison BM

    更新日期:2020-11-03 00:00:00

  • Quantitative Fluxomics of Circulating Metabolites.

    abstract::Mammalian organs are nourished by nutrients carried by the blood circulation. These nutrients originate from diet and internal stores, and can undergo various interconversions before their eventual use as tissue fuel. Here we develop isotope tracing, mass spectrometry, and mathematical analysis methods to determine th...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.07.013

    authors: Hui S,Cowan AJ,Zeng X,Yang L,TeSlaa T,Li X,Bartman C,Zhang Z,Jang C,Wang L,Lu W,Rojas J,Baur J,Rabinowitz JD

    更新日期:2020-10-06 00:00:00

  • Getting Warmer: Following One's Gut to Build Bone.

    abstract::In this issue of the Cell Metabolism, Chevalier et al. show that a warm environment produces changes in the composition of intestinal microbiota and that these changes can prevent bone loss due to hypogonadism. Dovetailing with prior studies on the ability of probiotics to reverse hypogonadism-induced osteopenia, the ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.09.010

    authors: Iqbal J,Yuen T,Zaidi M

    更新日期:2020-10-06 00:00:00

  • Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation.

    abstract::Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes in the gut microbiota appear to be important. The inhibitory role of mic...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.07.012

    authors: Koh A,Mannerås-Holm L,Yunn NO,Nilsson PM,Ryu SH,Molinaro A,Perkins R,Smith JG,Bäckhed F

    更新日期:2020-10-06 00:00:00

  • Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.

    abstract::Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alpha-ketoglutarate (delivered in the form of a calcium salt, CaAKG) on healthspan and lifespan in C57BL...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.08.004

    authors: Asadi Shahmirzadi A,Edgar D,Liao CY,Hsu YM,Lucanic M,Asadi Shahmirzadi A,Wiley CD,Gan G,Kim DE,Kasler HG,Kuehnemann C,Kaplowitz B,Bhaumik D,Riley RR,Kennedy BK,Lithgow GJ

    更新日期:2020-09-01 00:00:00

  • Break on Through: Golgi-Derived Vesicles Aid in Mitochondrial Fission.

    abstract::Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, iden...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.05.010

    authors: Rasmussen ML,Robertson GL,Gama V

    更新日期:2020-06-02 00:00:00

  • From the Transcriptome to Electrophysiology: Searching for the Underlying Cause of Diabetes.

    abstract::Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlatio...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.04.012

    authors: Kravets V,Benninger RKP

    更新日期:2020-05-05 00:00:00

  • Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1β.

    abstract::Postprandial hypoglycemia is a disabling complication of the treatment of obesity by gastric bypass surgery. So far, no therapy exists, and the underlying mechanisms remain unclear. Here, we hypothesized that glucose-induced IL-1β leads to an exaggerated insulin response in this condition. Therefore, we conducted a pl...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.02.013

    authors: Hepprich M,Wiedemann SJ,Schelker BL,Trinh B,Stärkle A,Geigges M,Löliger J,Böni-Schnetzler M,Rudofsky G,Donath MY

    更新日期:2020-04-07 00:00:00

  • NADH Ties One-Carbon Metabolism to Cellular Respiration.

    abstract::In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.03.012

    authors: Maynard AG,Kanarek N

    更新日期:2020-04-07 00:00:00

  • Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.

    abstract::Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.02.012

    authors: Ducrocq F,Walle R,Contini A,Oummadi A,Caraballo B,van der Veldt S,Boyer ML,Aby F,Tolentino-Cortez T,Helbling JC,Martine L,Grégoire S,Cabaret S,Vancassel S,Layé S,Kang JX,Fioramonti X,Berdeaux O,Barreda-Gómez G,Masso

    更新日期:2020-04-07 00:00:00

  • AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control.

    abstract::The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are interlinked, opposing signaling pathways involved in sensing availability of nutrients and energy and regulation of cell growth. AMPK (Yin, or the "dark side") is switched on by lack of energy or nutrients and inhibits cell growth, whil...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2020.01.015

    authors: González A,Hall MN,Lin SC,Hardie DG

    更新日期:2020-03-03 00:00:00

  • Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function.

    abstract::Regulatory T cells (Tregs) subdue immune responses. Central to Treg activation are changes in lipid metabolism that support their survival and function. Fatty acid binding proteins (FABPs) are a family of lipid chaperones required to facilitate uptake and intracellular lipid trafficking. One family member, FABP5, is e...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.11.021

    authors: Field CS,Baixauli F,Kyle RL,Puleston DJ,Cameron AM,Sanin DE,Hippen KL,Loschi M,Thangavelu G,Corrado M,Edwards-Hicks J,Grzes KM,Pearce EJ,Blazar BR,Pearce EL

    更新日期:2020-02-04 00:00:00

  • Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.

    abstract::To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists. Similarly, activating CalcrNTS neurons decre...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.12.012

    authors: Cheng W,Gonzalez I,Pan W,Tsang AH,Adams J,Ndoka E,Gordian D,Khoury B,Roelofs K,Evers SS,MacKinnon A,Wu S,Frikke-Schmidt H,Flak JN,Trevaskis JL,Rhodes CJ,Fukada SI,Seeley RJ,Sandoval DA,Olson DP,Blouet C,Myers MG

    更新日期:2020-02-04 00:00:00

  • Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1.

    abstract::Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of MRI, though its ability to inform on relevant changes to biochemistry in humans remains unclear. In this work, we image pyruvate metabolism in patients, assessing the reproducibility of delivery and conversion in the setting of p...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.08.024

    authors: Granlund KL,Tee SS,Vargas HA,Lyashchenko SK,Reznik E,Fine S,Laudone V,Eastham JA,Touijer KA,Reuter VE,Gonen M,Sosa RE,Nicholson D,Guo YW,Chen AP,Tropp J,Robb F,Hricak H,Keshari KR

    更新日期:2020-01-07 00:00:00

  • Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding.

    abstract::Microglia play a crucial role in immune responses, including inflammation. Diet-induced obesity (DIO) triggers microglia activation and hypothalamic inflammation as early as 3 days after high-fat diet (HFD) exposure, before changes in body weight occur. The intracellular mechanism(s) responsible for HFD-induced microg...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.08.010

    authors: Kim JD,Yoon NA,Jin S,Diano S

    更新日期:2019-11-05 00:00:00

  • The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease.

    abstract::Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key componen...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2019.10.010

    authors: Kisseleva T,Brenner DA

    更新日期:2019-11-05 00:00:00

  • United They Stand, Divided They Fall.

    abstract::Cancer cells that leave their natural environment during metastatic spread must adapt to numerous stresses to survive. In this issue, Labuschagne et al. (2019) highlight one adaptive mechanism to overcome these stresses that involves cell clustering, which induces a hypoxic environment and metabolic rewiring to buffer...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2019.09.008

    authors: Harris IS,Brugge JS

    更新日期:2019-10-01 00:00:00

  • Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease.

    abstract::miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression and the function of...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2019.07.011

    authors: Mori MA,Ludwig RG,Garcia-Martin R,Brandão BB,Kahn CR

    更新日期:2019-10-01 00:00:00

  • Microglia Metabolic Breakdown Drives Alzheimer's Pathology.

    abstract::Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with am...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2019.08.017

    authors: Bennett FC,Liddelow SA

    更新日期:2019-09-03 00:00:00

  • Medicine in the Fourth Dimension.

    abstract::The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2019.06.019

    authors: Cederroth CR,Albrecht U,Bass J,Brown SA,Dyhrfjeld-Johnsen J,Gachon F,Green CB,Hastings MH,Helfrich-Förster C,Hogenesch JB,Lévi F,Loudon A,Lundkvist GB,Meijer JH,Rosbash M,Takahashi JS,Young M,Canlon B

    更新日期:2019-08-06 00:00:00

  • Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

    abstract::Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lip...

    journal_title:Cell metabolism

    pub_type: 信件

    doi:10.1016/j.cmet.2019.05.014

    authors: Bekkering S,Stiekema LCA,Bernelot Moens S,Verweij SL,Novakovic B,Prange K,Versloot M,Roeters van Lennep JE,Stunnenberg H,de Winther M,Stroes ESG,Joosten LAB,Netea MG,Riksen NP

    更新日期:2019-07-02 00:00:00

  • NAD+ Metabolism and Signaling.

    abstract::We caught up with some of the leading researchers in the NAD+ metabolism and signaling field as they gathered in Dublin for the 2019 FASEB Science Research Conference. Here they share their excitement from the rich history of NAD+ biology dating back over 100 years ago to a future of translation benefiting human healt...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.06.013

    authors:

    更新日期:2019-07-02 00:00:00

  • Physiological and Molecular Dissection of Daily Variance in Exercise Capacity.

    abstract::Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity betwee...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.03.012

    authors: Ezagouri S,Zwighaft Z,Sobel J,Baillieul S,Doutreleau S,Ladeuix B,Golik M,Verges S,Asher G

    更新日期:2019-07-02 00:00:00

  • Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice.

    abstract::The basis for region-specific neuronal toxicity in Huntington disease is unknown. Here, we show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes. Glucose is low in HdhQ(150/150) animals, and astrocytes in each brain region adapt by metabolically reprogramming their mitochondria ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.03.004

    authors: Polyzos AA,Lee DY,Datta R,Hauser M,Budworth H,Holt A,Mihalik S,Goldschmidt P,Frankel K,Trego K,Bennett MJ,Vockley J,Xu K,Gratton E,McMurray CT

    更新日期:2019-06-04 00:00:00

  • Metabolic Adaptation Sets the Fate of Regulatory Macrophages.

    abstract::In this issue of Cell Metabolism, Du et al. (2019) describe how insulin-like growth factor 2 (IGF-2), a protein with structural similarity to insulin, induces an anti-inflammatory phenotype in maturing macrophages through reprogramming of their mitochondrial metabolism. These anti-inflammatory properties are maintaine...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2019.05.012

    authors: Domínguez-Andrés J,Netea MG

    更新日期:2019-06-04 00:00:00

  • Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells.

    abstract::Zika virus is a pathogen that poses serious consequences, including congenital microcephaly. Although many viruses reprogram host cell metabolism, whether Zika virus alters cellular metabolism and the functional consequences of Zika-induced metabolic changes remain unknown. Here, we show that Zika virus infection diff...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.01.024

    authors: Thaker SK,Chapa T,Garcia G Jr,Gong D,Schmid EW,Arumugaswami V,Sun R,Christofk HR

    更新日期:2019-05-07 00:00:00

  • ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition.

    abstract::Metabolic reprogramming plays an important role in supporting tumor growth. However, little is known about the metabolic alterations that promote cancer metastasis. In this study, we identify acyl-CoA thioesterase 12 (ACOT12) as a key player in hepatocellular carcinoma (HCC) metastasis. The expression of ACOT12 is sig...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.12.019

    authors: Lu M,Zhu WW,Wang X,Tang JJ,Zhang KL,Yu GY,Shao WQ,Lin ZF,Wang SH,Lu L,Zhou J,Wang LX,Jia HL,Dong QZ,Chen JH,Lu JQ,Qin LX

    更新日期:2019-04-02 00:00:00

  • Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization.

    abstract::The isolation and biochemical characterization of lipid droplet (LD)-associated mitochondria revealed the capacity of the cell to produce and maintain distinct mitochondrial populations carrying disparate proteome and dissimilar capacities to oxidize fatty acids and pyruvate. With mitochondrial motility being a centra...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2019.02.011

    authors: Benador IY,Veliova M,Liesa M,Shirihai OS

    更新日期:2019-04-02 00:00:00

  • Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin.

    abstract::Mitochondria are dynamic organelles that have been linked to stem cell homeostasis. However, the mechanisms involved in mitochondrial regulation of stem cell fate determination remain elusive. Here we discover that epithelial-mesenchymal transition (EMT), a key process in cancer progression, induces mitochondrial fusi...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.11.004

    authors: Wu MJ,Chen YS,Kim MR,Chang CC,Gampala S,Zhang Y,Wang Y,Chang CY,Yang JY,Chang CJ

    更新日期:2019-04-02 00:00:00

  • Fatty Acid Desaturation Gets a NAD+ Reputation.

    abstract::delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids. In this issue, Kim et al. (2019) show that production of NAD+ by this desaturase reaction is an adaptive response to NAD+ depletion that may regulate cellular REDOX status. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2019.03.007

    authors: Lutkewitte AJ,Burgess SC,Finck BN

    更新日期:2019-04-02 00:00:00

  • Single-Cell RNA-Seq of the Pancreatic Islets--a Promise Not yet Fulfilled?

    abstract::In the past 3 years, we have seen a flurry of publications on single-cell RNA sequencing (RNA-seq) analyses of pancreatic islets from mouse and human. This technology holds the promise to refine cell-type signatures and discover cellular heterogeneity among the canonical endocrine cell types such as the glucagon-produ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2018.11.016

    authors: Wang YJ,Kaestner KH

    更新日期:2019-03-05 00:00:00

  • Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State.

    abstract::Understanding the neural framework behind appetite control is fundamental to developing effective therapies to combat the obesity epidemic. The paraventricular hypothalamus (PVH) is critical for appetite regulation, yet, the real-time, physiological response properties of PVH neurons to nutrients are unknown. Using a ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.10.016

    authors: Li C,Navarrete J,Liang-Guallpa J,Lu C,Funderburk SC,Chang RB,Liberles SD,Olson DP,Krashes MJ

    更新日期:2019-03-05 00:00:00

  • Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.

    abstract::The interaction between the immune system and endocrine cells in the pancreas is crucial for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) enables multiplexed assessment of the abundance and localization of more than 30 proteins on the same tissue section at 1-μm resolution. Her...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.01.003

    authors: Wang YJ,Traum D,Schug J,Gao L,Liu C,HPAP Consortium.,Atkinson MA,Powers AC,Feldman MD,Naji A,Chang KM,Kaestner KH

    更新日期:2019-03-05 00:00:00

  • "Deepening" Insight on Skin Aging and Anti-microbial Immunity.

    abstract::Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired a...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2019.02.006

    authors: Kobayashi T,Nagao K

    更新日期:2019-03-05 00:00:00

  • Mast Cell-Derived Histamine Regulates Liver Ketogenesis via Oleoylethanolamide Signaling.

    abstract::The conversion of lipolysis-derived fatty acids into ketone bodies (ketogenesis) is a crucial metabolic adaptation to prolonged periods of food scarcity. The process occurs primarily in liver mitochondria and is initiated by fatty-acid-mediated stimulation of the ligand-operated transcription factor, peroxisome prolif...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.09.014

    authors: Misto A,Provensi G,Vozella V,Passani MB,Piomelli D

    更新日期:2019-01-08 00:00:00

  • Moving beyond GWAS and eQTL Analysis to Validated Hits in Chronic Kidney Disease.

    abstract::Genome-wide association studies (GWAS) have identified multiple chronic kidney disease (CKD)-associated single-nucleotide polymorphisms (SNPs) mainly localized to non-coding genomic regions. To understand which genes and which cell types are affected by these genetic variants, compartment-specific transcriptome, genom...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2018.12.009

    authors: Müller-Deile J,Jobst-Schwan T,Schiffer M

    更新日期:2019-01-08 00:00:00

  • On the Complexity of PAHSA Research.

    abstract::Reporting in Cell Metabolism, Pflimlin et al. recently found no beneficial effect of PAHSAs on glucose control in mice on several high-fat diets. Kuda cautions that due to methodological differences, the data must be carefully reinterpreted, emphasizing that olive oil contains high amounts of FAHFAs, potentially maski...

    journal_title:Cell metabolism

    pub_type: 评论,信件

    doi:10.1016/j.cmet.2018.09.006

    authors: Kuda O

    更新日期:2018-10-02 00:00:00

  • Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.

    abstract::Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.05.022

    authors: Wang QA,Song A,Chen W,Schwalie PC,Zhang F,Vishvanath L,Jiang L,Ye R,Shao M,Tao C,Gupta RK,Deplancke B,Scherer PE

    更新日期:2018-08-07 00:00:00

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