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Of mice and men: not ExAKTly the same?

Abstract：

:The serine-threonine protein kinase Akt2, also known as PKBβ, has been shown to regulate glucose and lipid metabolism in animal models. In a recent study published in Science, Hussain et al. (2011) report that in human subjects an activating mutation of Akt2 leads to hypoglycemia and, unexpectedly, asymmetric overgrowth.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Wan M,Birnbaum MJ

doi

10.1016/j.cmet.2011.11.009

subject

Has Abstract

pub_date

2011-12-07 00:00:00

pages

722-3

issue

6

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(11)00428-1

journal_volume

14

pub_type

评论,杂志文章

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