Abstract：
:Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term effects of sweet/energy imbalance. In flies, chronic sweet/energy imbalance promoted hyperactivity, insomnia, glucose intolerance, enhanced sweet taste perception, and a sustained increase in food and calories consumed, effects that are reversed upon sucralose removal. Mechanistically, this response was mapped to the ancient insulin, catecholamine, and NPF/NPY systems and the energy sensor AMPK, which together comprise a novel neuronal starvation response pathway. Interestingly, chronic sweet/energy imbalance promoted increased food intake in mammals as well, and this also occurs through an NPY-dependent mechanism. Together, our data show that chronic consumption of a sweet/energy imbalanced diet triggers a conserved neuronal fasting response and increases the motivation to eat.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Wang QP,Lin YQ,Zhang L,Wilson YA,Oyston LJ,Cotterell J,Qi Y,Khuong TM,Bakhshi N,Planchenault Y,Browman DT,Lau MT,Cole TA,Wong AC,Simpson SJ,Cole AR,Penninger JM,Herzog H,Neely GGdoi
10.1016/j.cmet.2016.06.010subject
Has Abstractpub_date
2016-07-12 00:00:00pages
75-90issue
1eissn
1550-4131issn
1932-7420pii
S1550-4131(16)30296-0journal_volume
24pub_type
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