Abstract：
:Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR) in median eminence tanycytes followed by MBH neurons, a process requiring tanycytic ERK signaling and the passage of leptin through the cerebrospinal fluid. In mice lacking the signal-transducing LepRb isoform or with diet-induced obesity, leptin taken up by tanycytes accumulates in the median eminence and fails to reach the MBH. Triggering ERK signaling in tanycytes with EGF reestablishes leptin transport, elicits MBH neuron activation and energy expenditure in obese animals, and accelerates the restoration of leptin sensitivity upon the return to a normal-fat diet. ERK-dependent leptin transport by tanycytes could thus play a critical role in the pathophysiology of leptin resistance, and holds therapeutic potential for treating obesity.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Balland E,Dam J,Langlet F,Caron E,Steculorum S,Messina A,Rasika S,Falluel-Morel A,Anouar Y,Dehouck B,Trinquet E,Jockers R,Bouret SG,Prévot Vdoi
10.1016/j.cmet.2013.12.015subject
Has Abstractpub_date
2014-02-04 00:00:00pages
293-301issue
2eissn
1550-4131issn
1932-7420journal_volume
19pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract：:Obesity and atherosclerosis-related diseases account for over one-third of deaths in the western world. Controlling these conditions remains a major challenge due to an incomplete understanding of the molecular pathways involved. Here, we show that Wip1 phosphatase, a known negative regulator of Atm-dependent signalin...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.06.003
更新日期：2012-07-03 00:00:00
abstract：:Reductionist in vitro T cell assays have identified metabolic pathways critical for T cell function within the tumor microenvironment. We discuss the challenges of testing these concepts using in vivo tumor models. ...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2018.07.009
更新日期：2018-08-07 00:00:00
abstract：:Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic signaling molecule involved in cardiovascular and metabolic regulation. More recently, an alternative pathway for the formation of this free radical has been explored. The inorganic anions nitrate (NO3-) and nitrite (NO2-), origi...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2018.06.007
更新日期：2018-07-03 00:00:00
abstract：:Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue culture are much higher than what has been described in vivo. Here...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.09.006
更新日期：2016-11-08 00:00:00
abstract：:What are the pathways that underlie the coordinated responses of an organism to well-fed and food-deprived states? A report in this issue of Cell Metabolism suggests that starvation functions via a muscarinic acetylcholine receptor to activate MAP kinase signaling in the pharyngeal muscle of C. elegans (You et al., 20...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2006.03.002
更新日期：2006-04-01 00:00:00
abstract：:To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists. Similarly, activating CalcrNTS neurons decre...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2019.12.012
更新日期：2020-02-04 00:00:00
abstract：:Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.05.022
更新日期：2018-08-07 00:00:00
abstract：:Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2017.06.019
更新日期：2017-07-05 00:00:00
abstract：:The complexes of the electron transport chain associate into large macromolecular assemblies, which are believed to facilitate efficient electron flow. We have identified a conserved mitochondrial protein, named respiratory supercomplex factor 1 (Rcf1-Yml030w), that is required for the normal assembly of respiratory s...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.02.006
更新日期：2012-03-07 00:00:00
abstract：:In mice, interleukin-6 (IL-6) improves glucose tolerance via stimulation of glucagon-like peptide 1 (GLP-1) secretion. In this issue of Cell Metabolism, Lang Lehrskov et al. (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an ov...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2018.05.013
更新日期：2018-06-05 00:00:00
abstract：:Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2016.12.014
更新日期：2017-01-10 00:00:00
abstract：:The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here, we show that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues. In the inguinal depot, cold exposure resulted in elevated expression levels of brown-fat-ass...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2008.11.009
更新日期：2009-01-07 00:00:00
abstract：:delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids. In this issue, Kim et al. (2019) show that production of NAD+ by this desaturase reaction is an adaptive response to NAD+ depletion that may regulate cellular REDOX status. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2019.03.007
更新日期：2019-04-02 00:00:00
abstract：:The delivery of blood-borne molecules conveying metabolic information to neural networks that regulate energy homeostasis is restricted by brain barriers. The fenestrated endothelium of median eminence microvessels and tight junctions between tanycytes together compose one of these. Here, we show that the decrease in ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2013.03.004
更新日期：2013-04-02 00:00:00
abstract：:Small-molecule ligands of nuclear hormone receptors (NHRs) govern the transcriptional regulation of metazoan development, cell differentiation, and metabolism. However, the physiological ligands of many NHRs remain poorly characterized, primarily due to lack of robust analytical techniques. Using comparative metabolom...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2013.11.024
更新日期：2014-01-07 00:00:00
abstract：:Lipid droplets (LDs) are cellular storage organelles for neutral lipids that vary in size and abundance according to cellular needs. Physiological conditions that promote lipid storage rapidly and markedly increase LD volume and surface. How the need for surface phospholipids is sensed and balanced during this process...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2011.07.013
更新日期：2011-10-05 00:00:00
abstract：:Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the role of LRP5 in human...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.01.009
更新日期：2015-02-03 00:00:00
abstract：:Myriad strategies have been explored to compensate for the lack of dystrophin or to skip mutations that cause the lethal disease Duchenne muscular dystrophy (DMD). A new study shows that gene editing strategies used by bacteria can be applied in zygotes of a mouse model of DMD to correct the genetic defect that causes...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.11.011
更新日期：2014-12-02 00:00:00
abstract：:The ability of hormones such as insulin, leptin, and cholecystokinin to alter food intake is influenced by intricate interactions between homeostatic and non-homeostatic factors. Consequently, when administered exogenously, the likelihood of these hormones influencing food intake is probabilistic, leading to difficult...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.08.017
更新日期：2015-09-01 00:00:00
abstract：:Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria. Although these core enzymes are well studied, additional mitochondrial transporters and regulatory factors are predicted to be required. To discover such unkn...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.06.012
更新日期：2009-08-01 00:00:00
abstract：:The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and resistance, we have generated mice with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency (IL-6Ralpha(L-KO) mice). These anima...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.06.011
更新日期：2010-09-08 00:00:00
abstract：:The fibroblast growth factor receptor 4 (FGFR4)-R388 single-nucleotide polymorphism has been associated with cancer risk and prognosis. Here we show that the FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3/5 signaling. This STAT activation transcriptionally induces Grb14 in pancreatic en...
journal_title：Cell metabolism
pub_type： 杂志文章,收录出版
doi：10.1016/j.cmet.2013.05.002
更新日期：2013-06-04 00:00:00
abstract：:In this issue of the Cell Metabolism, Chevalier et al. show that a warm environment produces changes in the composition of intestinal microbiota and that these changes can prevent bone loss due to hypogonadism. Dovetailing with prior studies on the ability of probiotics to reverse hypogonadism-induced osteopenia, the ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.09.010
更新日期：2020-10-06 00:00:00
abstract：:Type 2 diabetes is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. Previous studies using a candidate gene approach, family linkage studies, and gene expression profiling uncov...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2008.08.006
更新日期：2008-09-01 00:00:00
abstract：:In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support c...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2017.11.008
更新日期：2017-12-05 00:00:00
abstract：:The trace element copper (Cu) is a cofactor for biochemical functions ranging from energy generation to iron (Fe) acquisition, angiogenesis, and free radical detoxification. While Cu is essential for life, the molecules that mediate dietary Cu uptake have not been identified. Ctr1 is a homotrimeric protein, conserved ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.08.009
更新日期：2006-09-01 00:00:00
abstract：:Mammary epithelial cells transition between periods of proliferation and quiescence during development, menstrual cycles, and pregnancy, and as a result of oncogenic transformation. Utilizing an organotypic 3D tissue culture model coupled with quantitative metabolomics and proteomics, we identified significant differe...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.03.016
更新日期：2016-05-10 00:00:00
abstract：:Reducing obesity requires an elevation of energy expenditure and/or a suppression of food intake. Here we show that enhancing hepatic glycolysis reduces body weight and adiposity in obese mice. Overexpression of glucokinase or 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is used to increase hepatic glycolysis....
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2005.07.003
更新日期：2005-08-01 00:00:00
abstract：:Mitochondrial dysfunction is associated with skeletal muscle pathology, including cachexia, sarcopenia, and the muscular dystrophies. ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA. Here we report that activation of ACL in skeletal muscle resu...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.05.006
更新日期：2015-06-02 00:00:00
abstract：:Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging. ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2007.08.007
更新日期：2007-09-01 00:00:00
