Fatty Acid Desaturation Gets a NAD+ Reputation.

Abstract:

:delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids. In this issue, Kim et al. (2019) show that production of NAD+ by this desaturase reaction is an adaptive response to NAD+ depletion that may regulate cellular REDOX status.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Lutkewitte AJ,Burgess SC,Finck BN

doi

10.1016/j.cmet.2019.03.007

subject

Has Abstract

pub_date

2019-04-02 00:00:00

pages

790-792

issue

4

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(19)30135-4

journal_volume

29

pub_type

评论,杂志文章
  • A CRTCal link between energy and life span.

    abstract::Cutting down calories prolongs life, but how this works remains largely unknown. A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2011.03.012

    authors: Brunet A

    更新日期:2011-04-06 00:00:00

  • Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans.

    abstract::Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, dec...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.05.024

    authors: Roux AE,Langhans K,Huynh W,Kenyon C

    更新日期:2016-06-14 00:00:00

  • The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.

    abstract::The PAR-domain basic leucine zipper (PAR bZip) transcription factors DBP, TEF, and HLF accumulate in a highly circadian manner in several peripheral tissues, including liver and kidney. Mice devoid of all three of these proteins are born at expected Mendelian ratios, but are epilepsy prone, age at an accelerated rate,...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2006.04.015

    authors: Gachon F,Olela FF,Schaad O,Descombes P,Schibler U

    更新日期:2006-07-01 00:00:00

  • Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy.

    abstract::Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3 was shown to promote the expression of autophagy-related genes in skeletal muscle, the mechanisms triggering autophagy are unclear. We show that TSC1-deficient m...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2013.03.015

    authors: Castets P,Lin S,Rion N,Di Fulvio S,Romanino K,Guridi M,Frank S,Tintignac LA,Sinnreich M,Rüegg MA

    更新日期:2013-05-07 00:00:00

  • Metabolic Effects of Dietary Nitrate in Health and Disease.

    abstract::Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic signaling molecule involved in cardiovascular and metabolic regulation. More recently, an alternative pathway for the formation of this free radical has been explored. The inorganic anions nitrate (NO3-) and nitrite (NO2-), origi...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2018.06.007

    authors: Lundberg JO,Carlström M,Weitzberg E

    更新日期:2018-07-03 00:00:00

  • Medicine in the Fourth Dimension.

    abstract::The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2019.06.019

    authors: Cederroth CR,Albrecht U,Bass J,Brown SA,Dyhrfjeld-Johnsen J,Gachon F,Green CB,Hastings MH,Helfrich-Förster C,Hogenesch JB,Lévi F,Loudon A,Lundkvist GB,Meijer JH,Rosbash M,Takahashi JS,Young M,Canlon B

    更新日期:2019-08-06 00:00:00

  • Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism.

    abstract::Circulating levels of insulin and glucagon reflect the nutritional state of animals and elicit regulatory responses in the liver that maintain glucose and lipid homeostasis. The transcription factor Foxa2 activates lipid metabolism and ketogenesis during fasting and is inhibited via insulin-PI3K-Akt signaling-mediated...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2013.01.014

    authors: von Meyenn F,Porstmann T,Gasser E,Selevsek N,Schmidt A,Aebersold R,Stoffel M

    更新日期:2013-03-05 00:00:00

  • Insulin resistance in the defense against obesity.

    abstract::In the face of the current obesity epidemic, the nature of the relationship between overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state of excessive insulin action that elicits a series of cellular homeostatic responses, producing systemic insulin resistance. These responses occ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2012.03.001

    authors: Saltiel AR

    更新日期:2012-06-06 00:00:00

  • Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization.

    abstract::The isolation and biochemical characterization of lipid droplet (LD)-associated mitochondria revealed the capacity of the cell to produce and maintain distinct mitochondrial populations carrying disparate proteome and dissimilar capacities to oxidize fatty acids and pyruvate. With mitochondrial motility being a centra...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2019.02.011

    authors: Benador IY,Veliova M,Liesa M,Shirihai OS

    更新日期:2019-04-02 00:00:00

  • Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

    abstract::Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2008.03.006

    authors: López M,Lage R,Saha AK,Pérez-Tilve D,Vázquez MJ,Varela L,Sangiao-Alvarellos S,Tovar S,Raghay K,Rodríguez-Cuenca S,Deoliveira RM,Castañeda T,Datta R,Dong JZ,Culler M,Sleeman MW,Alvarez CV,Gallego R,Lelliott CJ,Carlin

    更新日期:2008-05-01 00:00:00

  • Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects.

    abstract::Nuclear receptors (NRs) are key regulators of gene expression and physiology. Nearly half of all human NRs lack endogenous ligands including estrogen-related receptor α (ERRα). ERRα has important roles in cancer, metabolism, and skeletal homeostasis. Affinity chromatography of tissue lipidomes with the ERRα ligand-bin...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.12.010

    authors: Wei W,Schwaid AG,Wang X,Wang X,Chen S,Chu Q,Saghatelian A,Wan Y

    更新日期:2016-03-08 00:00:00

  • Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.

    abstract::Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-elusive metabolic circuitries. Here, we show that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autopha...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2014.02.010

    authors: Eisenberg T,Schroeder S,Andryushkova A,Pendl T,Küttner V,Bhukel A,Mariño G,Pietrocola F,Harger A,Zimmermann A,Moustafa T,Sprenger A,Jany E,Büttner S,Carmona-Gutierrez D,Ruckenstuhl C,Ring J,Reichelt W,Schimmel K,Lee

    更新日期:2014-03-04 00:00:00

  • Feeding mistiming decreases reproductive fitness in flies.

    abstract::The diurnally active fruit flies prefer a major meal in the morning. Feeding the flies in the evening uncouples their metabolic cycle from circadian activity rhythms. A paper by Xu et al. in this issue of Cell Metabolism found that such uncoupled rhythms reduce egg laying. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2011.05.003

    authors: Gill S,Panda S

    更新日期:2011-06-08 00:00:00

  • Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile.

    abstract::C. difficile infection is a deadly disease that is influenced by the microbiome. In a recent article in Nature, Buffie et al. (2014) demonstrate that the ability of C. scindens to synthesize secondary bile acids is crucial to providing resistance to C. difficile infection. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2014.12.016

    authors: Greathouse KL,Harris CC,Bultman SJ

    更新日期:2015-01-06 00:00:00

  • Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness.

    abstract::Mitochondria undergo architectural/functional changes in response to metabolic inputs. How this process is regulated in physiological feeding/fasting states remains unclear. Here we show that mitochondrial dynamics (notably fission and mitophagy) and biogenesis are transcriptional targets of the circadian regulator Bm...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.08.006

    authors: Jacobi D,Liu S,Burkewitz K,Kory N,Knudsen NH,Alexander RK,Unluturk U,Li X,Kong X,Hyde AL,Gangl MR,Mair WB,Lee CH

    更新日期:2015-10-06 00:00:00

  • TOR regulation: sorting out the answers.

    abstract::Components involved in vesicle trafficking processes such as secretion, endocytosis, and autophagy are gaining recognition as important regulators and effectors of target of rapamycin (TOR) signaling. A recent report by now implicates Pmr1, a secretory pathway Ca(2+)/Mn(2+) ATPase located in the Golgi apparatus, as a ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2006.12.008

    authors: Neufeld TP

    更新日期:2007-01-01 00:00:00

  • Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

    abstract::XBP1 is a key regulator of the unfolded protein response (UPR), which is involved in a wide range of physiological and pathological processes. XBP1 ablation in liver causes profound hypolipidemia in mice, highlighting its critical role in lipid metabolism. XBP1 deficiency triggers feedback activation of its upstream e...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2012.09.004

    authors: So JS,Hur KY,Tarrio M,Ruda V,Frank-Kamenetsky M,Fitzgerald K,Koteliansky V,Lichtman AH,Iwawaki T,Glimcher LH,Lee AH

    更新日期:2012-10-03 00:00:00

  • Clking on PGC-1alpha to inhibit gluconeogenesis.

    abstract::The link between Akt activation and gluconeogenic repression remains unclear, despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1alpha, blunting hepatic glucose production. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2009.12.003

    authors: Cantó C,Auwerx J

    更新日期:2010-01-01 00:00:00

  • Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation.

    abstract::The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.02.012

    authors: Abraham RT

    更新日期:2016-03-08 00:00:00

  • Food for Thought: Revisiting the Complexity of Food Intake.

    abstract::The ability of hormones such as insulin, leptin, and cholecystokinin to alter food intake is influenced by intricate interactions between homeostatic and non-homeostatic factors. Consequently, when administered exogenously, the likelihood of these hormones influencing food intake is probabilistic, leading to difficult...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.08.017

    authors: Woods SC,Begg DP

    更新日期:2015-09-01 00:00:00

  • Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action.

    abstract::The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and resistance, we have generated mice with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency (IL-6Ralpha(L-KO) mice). These anima...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2010.06.011

    authors: Wunderlich FT,Ströhle P,Könner AC,Gruber S,Tovar S,Brönneke HS,Juntti-Berggren L,Li LS,van Rooijen N,Libert C,Berggren PO,Brüning JC

    更新日期:2010-09-08 00:00:00

  • MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2.

    abstract::Repression of mitochondrial respiration represents an evolutionarily ancient cellular adaptation to hypoxia and profoundly influences cell survival and function; however, the underlying molecular mechanisms are incompletely understood. Primarily utilizing pulmonary arterial endothelial cells as a representative hypoxi...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2009.08.015

    authors: Chan SY,Zhang YY,Hemann C,Mahoney CE,Zweier JL,Loscalzo J

    更新日期:2009-10-01 00:00:00

  • Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1.

    abstract::Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of MRI, though its ability to inform on relevant changes to biochemistry in humans remains unclear. In this work, we image pyruvate metabolism in patients, assessing the reproducibility of delivery and conversion in the setting of p...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.08.024

    authors: Granlund KL,Tee SS,Vargas HA,Lyashchenko SK,Reznik E,Fine S,Laudone V,Eastham JA,Touijer KA,Reuter VE,Gonen M,Sosa RE,Nicholson D,Guo YW,Chen AP,Tropp J,Robb F,Hricak H,Keshari KR

    更新日期:2020-01-07 00:00:00

  • Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy.

    abstract::Peroxisomes play a central role in lipid metabolism, and their function depends on molecular oxygen. Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1α and Hif-2α) to mediate adaptive responses, but it remains unknown if peroxisome homeosta...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2014.09.017

    authors: Walter KM,Schönenberger MJ,Trötzmüller M,Horn M,Elsässer HP,Moser AB,Lucas MS,Schwarz T,Gerber PA,Faust PL,Moch H,Köfeler HC,Krek W,Kovacs WJ

    更新日期:2014-11-04 00:00:00

  • Transgenerational inheritance of longevity: epigenetic mysteries abound.

    abstract::Transgenerational inheritance of epigenetic characteristics in plants has been reported, whereas nongenetic persistence of complex phenotypes in animals is controversial. A recent report by Anne Brunet and colleagues describes a fascinating example of persistence across generations of extended life span in worm and ex...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2011.12.012

    authors: Berger SL

    更新日期:2012-01-04 00:00:00

  • FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.

    abstract::The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mice, we show that βK...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2014.07.012

    authors: Owen BM,Ding X,Morgan DA,Coate KC,Bookout AL,Rahmouni K,Kliewer SA,Mangelsdorf DJ

    更新日期:2014-10-07 00:00:00

  • Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

    abstract::Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria. Although these core enzymes are well studied, additional mitochondrial transporters and regulatory factors are predicted to be required. To discover such unkn...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2009.06.012

    authors: Nilsson R,Schultz IJ,Pierce EL,Soltis KA,Naranuntarat A,Ward DM,Baughman JM,Paradkar PN,Kingsley PD,Culotta VC,Kaplan J,Palis J,Paw BH,Mootha VK

    更新日期:2009-08-01 00:00:00

  • An Emerging Technology Framework for the Neurobiology of Appetite.

    abstract::Advances in neuro-technology for mapping, manipulating, and monitoring molecularly defined cell types are rapidly advancing insight into neural circuits that regulate appetite. Here, we review these important tools and their applications in circuits that control food seeking and consumption. Technical capabilities pro...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2015.12.002

    authors: Sternson SM,Atasoy D,Betley JN,Henry FE,Xu S

    更新日期:2016-02-09 00:00:00

  • Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.

    abstract::Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.02.012

    authors: Ducrocq F,Walle R,Contini A,Oummadi A,Caraballo B,van der Veldt S,Boyer ML,Aby F,Tolentino-Cortez T,Helbling JC,Martine L,Grégoire S,Cabaret S,Vancassel S,Layé S,Kang JX,Fioramonti X,Berdeaux O,Barreda-Gómez G,Masso

    更新日期:2020-04-07 00:00:00

  • Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle.

    abstract::Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN prote...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.08.023

    authors: Sanders MA,Madoux F,Mladenovic L,Zhang H,Ye X,Angrish M,Mottillo EP,Caruso JA,Halvorsen G,Roush WR,Chase P,Hodder P,Granneman JG

    更新日期:2015-11-03 00:00:00