Abstract：
:Lipid droplets (LDs) are cellular storage organelles for neutral lipids that vary in size and abundance according to cellular needs. Physiological conditions that promote lipid storage rapidly and markedly increase LD volume and surface. How the need for surface phospholipids is sensed and balanced during this process is unknown. Here, we show that phosphatidylcholine (PC) acts as a surfactant to prevent LD coalescence, which otherwise yields large, lipolysis-resistant LDs and triglyceride (TG) accumulation. The need for additional PC to coat the enlarging surface during LD expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase (CCT), to growing LD surfaces. The requirement, targeting, and activation of CCT to growing LDs were similar in cells of Drosophila and mice. Our results reveal a mechanism to maintain PC homeostasis at the expanding LD monolayer through targeted activation of a key PC synthesis enzyme.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Krahmer N,Guo Y,Wilfling F,Hilger M,Lingrell S,Heger K,Newman HW,Schmidt-Supprian M,Vance DE,Mann M,Farese RV Jr,Walther TCdoi
10.1016/j.cmet.2011.07.013subject
Has Abstractpub_date
2011-10-05 00:00:00pages
504-15issue
4eissn
1550-4131issn
1932-7420pii
S1550-4131(11)00336-6journal_volume
14pub_type
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