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Iron and diabetes risk.

Abstract：

:Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failure and insulin resistance. Iron also regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role. The underlying molecular mechanisms mediating these effects are numerous and incompletely understood but include oxidant stress and modulation of adipokines and intracellular signal transduction pathways.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Simcox JA,McClain DA

doi

10.1016/j.cmet.2013.02.007

subject

Has Abstract

pub_date

2013-03-05 00:00:00

pages

329-41

issue

3

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(13)00055-7

journal_volume

17

pub_type

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