Abstract：
:A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (∼20% of the normal weight adult population) have a greater than 3-fold higher risk of all-cause mortality and/or cardiovascular events. Here we address to what extent major risk phenotypes determine metabolic health in lean compared to overweight and obese people and provide support for the existence of a lipodystrophy-like phenotype in the general population. Furthermore, we highlight the molecular mechanisms that induce this phenotype. Finally, we propose strategies as to how this knowledge could be implemented in the prevention and treatment of cardiometabolic diseases in different stages of adiposity in routine clinical practice.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Stefan N,Schick F,Häring HUdoi
10.1016/j.cmet.2017.07.008subject
Has Abstractpub_date
2017-08-01 00:00:00pages
292-300issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(17)30429-1journal_volume
26pub_type
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