Abstract：
:Understanding the neural framework behind appetite control is fundamental to developing effective therapies to combat the obesity epidemic. The paraventricular hypothalamus (PVH) is critical for appetite regulation, yet, the real-time, physiological response properties of PVH neurons to nutrients are unknown. Using a combination of fiber photometry, electrophysiology, immunohistochemistry, and neural manipulation strategies, we determined the population dynamics of four molecularly delineated PVH subsets implicated in feeding behavior: glucagon-like peptide 1 receptor (PVHGlp1r), melanocortin-4 receptor (PVHMc4r), oxytocin (PVHOxt), and corticotropin-releasing hormone (PVHCrh). We identified both calorie- and state-dependent sustained activity increases and decreases in PVHGlp1r and PVHCrh populations, respectively, while observing transient bulk changes of PVHMc4r, but no response in PVHOxt, neurons to food. Furthermore, we highlight the role of PVHGlp1r neurons in orchestrating acute feeding behavior, independent of the anti-obesity drug liraglutide, and demonstrate the indispensability of PVHGlp1r and PVHMc4r, but not PVHOxt or PVHCrh neurons, in body weight maintenance.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Li C,Navarrete J,Liang-Guallpa J,Lu C,Funderburk SC,Chang RB,Liberles SD,Olson DP,Krashes MJdoi
10.1016/j.cmet.2018.10.016subject
Has Abstractpub_date
2019-03-05 00:00:00pages
681-694.e5issue
3eissn
1550-4131issn
1932-7420pii
S1550-4131(18)30648-Xjournal_volume
29pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract：:Reductionist in vitro T cell assays have identified metabolic pathways critical for T cell function within the tumor microenvironment. We discuss the challenges of testing these concepts using in vivo tumor models. ...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2018.07.009
更新日期：2018-08-07 00:00:00
abstract：:Conservation of the rapamycin-sensitive TOR signaling network among eukaryotes has been instrumental to the rapid progress made in this field in recent years. A recent report in Molecular Cell (Urban et al., 2007) now extends this conservation to include Sch9, an AGC protein kinase family member from S. cerevisiae, wh...
journal_title：Cell metabolism
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cmet.2007.06.009
更新日期：2007-07-01 00:00:00
abstract：:Obese adipose tissue is characterized by infiltration of macrophages. We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue. This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-asso...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2008.08.015
更新日期：2008-10-01 00:00:00
abstract：:With the identification of its receptor in a highly specific region of the brain, interesting issues come to light regarding the normal physiological functions of GDF15, a secreted protein long identified as a biomarker of diverse disease states. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2017.10.017
更新日期：2017-12-05 00:00:00
abstract：:High sodium intake is a major risk factor for developing hypertension in diabetes. Promotion of sodium excretion reduces cardiometabolic lesions in diabetes. However, the interaction between sodium intake and glucose homeostasis remains elusive. Here, we report that high sodium intake remarkably increased natriuresis ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.02.019
更新日期：2016-04-12 00:00:00
abstract：:Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed th...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2014.03.020
更新日期：2014-04-01 00:00:00
abstract：:Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in turn leads to a potent profibrotic transcriptional program. The pathophysiological impact of adipose tissue fibrosis is likely to play an e...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2013.06.016
更新日期：2013-10-01 00:00:00
abstract：:A hypothesis that accounts for most of the available literature on insulin-stimulated GLUT4 translocation is that insulin action controls the access of GLUT4 vesicles to a constitutively active plasma-membrane fusion process. However, using an in vitro fusion assay, we show here that fusion is not constitutively activ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2005.08.007
更新日期：2005-09-01 00:00:00
abstract：:Mammary epithelial cells transition between periods of proliferation and quiescence during development, menstrual cycles, and pregnancy, and as a result of oncogenic transformation. Utilizing an organotypic 3D tissue culture model coupled with quantitative metabolomics and proteomics, we identified significant differe...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.03.016
更新日期：2016-05-10 00:00:00
abstract：:Over the past years, plenty of evidence has emerged illustrating how metabolism supports many aspects of cellular function and how metabolic reprogramming can drive cell differentiation and fate. Here, we present a method to assess the metabolic configuration of single cells within their native tissue microenvironment...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.08.014
更新日期：2017-11-07 00:00:00
abstract：:It is still unclear if the ability of key regulators of actin cytoskeletal remodeling to influence lipid metabolism contributes to kidney injury. In this issue of Cell Metabolism, Fu et al. (2020) show that junctional adhesion molecule-like (JAML) is a novel mediator of glomerular disease progression while suggesting ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.11.002
更新日期：2020-12-01 00:00:00
abstract：:Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we demonstrate that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (BCSCs) and cancer chemoresistance. Inhibiting JAK/STAT3 blocks BCSC self...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.11.001
更新日期：2018-01-09 00:00:00
abstract：:Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria. Although these core enzymes are well studied, additional mitochondrial transporters and regulatory factors are predicted to be required. To discover such unkn...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.06.012
更新日期：2009-08-01 00:00:00
abstract：:Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with am...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2019.08.017
更新日期：2019-09-03 00:00:00
abstract：:Hallmarks of aging that negatively impact health include weight gain and reduced physical fitness, which can increase insulin resistance and risk for many diseases, including type 2 diabetes. The underlying mechanism(s) for these phenomena is poorly understood. Here we report that aging increases DNA breaks and activa...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.04.008
更新日期：2017-05-02 00:00:00
abstract：:We investigated relationships among immune, metabolic, and sleep abnormalities in mice with non-metastatic mammary cancer. Tumor-bearing mice displayed interleukin-6 (IL-6)-mediated peripheral inflammation, coincident with altered hepatic glucose processing and sleep. Tumor-bearing mice were hyperphagic, had reduced s...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.04.021
更新日期：2018-07-03 00:00:00
abstract：:Signaling cascades during adipogenesis culminate in the expression of two essential adipogenic factors, PPARgamma and C/EBPalpha. Here we demonstrate that the IRE1alpha-XBP1 pathway, the most conserved branch of the unfolded protein response (UPR), is indispensable for adipogenesis. Indeed, XBP1-deficient mouse embryo...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.04.009
更新日期：2009-06-01 00:00:00
abstract：:Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD(+) biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in mammals. However, the significance of eNAMPT secretion remains unclear. Here we demonstrate that deacetylation of iNAMPT by the mammalian NAD(+)-dependent deacet...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.04.002
更新日期：2015-05-05 00:00:00
abstract：:Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these factors to the establishment of epigenetic patterns in human gametes is unknown. Here, we hypothesized that weight loss rem...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.11.004
更新日期：2016-02-09 00:00:00
abstract：:Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulation at the transcriptional level, much less is known about tempor...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.10.003
更新日期：2017-01-10 00:00:00
abstract：:BAD, a proapoptotic member of the Bcl-2 family of proteins, is regulated by phosphorylation. A recent study (Danial et al., 2008) suggests a phosphorylation-state-dependent bifunctional role of BAD in the regulation of glucose-stimulated insulin secretion and beta cell mass. ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2008.03.009
更新日期：2008-04-01 00:00:00
abstract：:Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD(+)) exhibits axon-protective effects in cultured neurons; however, its ability to block degeneration in vivo has been difficult to establish due to i...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.11.003
更新日期：2014-12-02 00:00:00
abstract：:Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-elusive metabolic circuitries. Here, we show that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autopha...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.02.010
更新日期：2014-03-04 00:00:00
abstract：:Lipid droplets (LDs) are cellular storage organelles for neutral lipids that vary in size and abundance according to cellular needs. Physiological conditions that promote lipid storage rapidly and markedly increase LD volume and surface. How the need for surface phospholipids is sensed and balanced during this process...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2011.07.013
更新日期：2011-10-05 00:00:00
abstract：:Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlatio...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.04.012
更新日期：2020-05-05 00:00:00
abstract：:AMPK is a kinase involved in cell energy homeostasis. In this issue of Cell Metabolism, Chopra and colleagues (2011) reveal a new function of AMPK in stimulating fat absorption. AMPK enhances the expression of the bile acid transporter, BSEP, by activating the coactivator SRC-2, thus promoting bile acid secretion. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2010.12.009
更新日期：2011-01-05 00:00:00
abstract：:Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the pathogenesis of microvascular complications of diabetes, including diabetic nephropathy. However, the signaling pathways by which hyperglycemia leads to mitochondrial dysfunction are not fully understood. Here we examined the...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.01.009
更新日期：2012-02-08 00:00:00
abstract：:In mice, interleukin-6 (IL-6) improves glucose tolerance via stimulation of glucagon-like peptide 1 (GLP-1) secretion. In this issue of Cell Metabolism, Lang Lehrskov et al. (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an ov...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2018.05.013
更新日期：2018-06-05 00:00:00
abstract：:Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be optimized by intermittent dietary energy restriction (ER) and exercise. Such energetic challenges engage adaptive cellular stress-response signaling pathways in neu...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2012.08.012
更新日期：2012-12-05 00:00:00
abstract：:Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, dec...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.05.024
更新日期：2016-06-14 00:00:00
