The Limits of Exercise Physiology: From Performance to Health.


:Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have been informed by studying highly trained athletes, in addition to healthy or unhealthy people. Recent progress has been made in regard to skeletal muscle metabolism and personalized exercise regimes. In this perspective, we review some of the historical milestones of exercise physiology, discuss how these inform contemporary knowledge, and speculate on future questions.


Cell Metab


Cell metabolism


Gabriel BM,Zierath JR




Has Abstract


2017-05-02 00:00:00














  • Iron and diabetes risk.

    abstract::Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failur...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Simcox JA,McClain DA

    更新日期:2013-03-05 00:00:00

  • Aging: all in the head?

    abstract::Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Bartke A

    更新日期:2007-09-01 00:00:00

  • Mitochondrial complex I plays an essential role in human respirasome assembly.

    abstract::The biogenesis and function of the mitochondrial respiratory chain (RC) involve the organization of RC enzyme complexes in supercomplexes or respirasomes through an unknown biosynthetic process. This leads to structural interdependences between RC complexes, which are highly relevant from biological and biomedical per...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Moreno-Lastres D,Fontanesi F,García-Consuegra I,Martín MA,Arenas J,Barrientos A,Ugalde C

    更新日期:2012-03-07 00:00:00

  • Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans.

    abstract::Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, dec...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Roux AE,Langhans K,Huynh W,Kenyon C

    更新日期:2016-06-14 00:00:00

  • New uses for old drugs: neonatal diabetes and sulphonylureas.

    abstract::The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Ashcroft FM

    更新日期:2010-03-03 00:00:00

  • Break on Through: Golgi-Derived Vesicles Aid in Mitochondrial Fission.

    abstract::Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, iden...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Rasmussen ML,Robertson GL,Gama V

    更新日期:2020-06-02 00:00:00

  • Single-Cell RNA-Seq of the Pancreatic Islets--a Promise Not yet Fulfilled?

    abstract::In the past 3 years, we have seen a flurry of publications on single-cell RNA sequencing (RNA-seq) analyses of pancreatic islets from mouse and human. This technology holds the promise to refine cell-type signatures and discover cellular heterogeneity among the canonical endocrine cell types such as the glucagon-produ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Wang YJ,Kaestner KH

    更新日期:2019-03-05 00:00:00

  • Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response.

    abstract::Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Wang QP,Lin YQ,Zhang L,Wilson YA,Oyston LJ,Cotterell J,Qi Y,Khuong TM,Bakhshi N,Planchenault Y,Browman DT,Lau MT,Cole TA,Wong AC,Simpson SJ,Cole AR,Penninger JM,Herzog H,Neely GG

    更新日期:2016-07-12 00:00:00

  • A bitter aftertaste: unintended effects of artificial sweeteners on the gut microbiome.

    abstract::Intestinal microbial communities regulate a range of host physiological functions, from energy harvest and glucose homeostasis to immune development and regulation. Suez et al. (2014) recently demonstrated that artificial sweeteners alter gut microbial communities, leading to glucose intolerance in both mice and human...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Bokulich NA,Blaser MJ

    更新日期:2014-11-04 00:00:00

  • mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc.

    abstract::Aerobic glycolysis (the Warburg effect) is a core hallmark of cancer, but the molecular mechanisms underlying it remain unclear. Here, we identify an unexpected central role for mTORC2 in cancer metabolic reprogramming where it controls glycolytic metabolism by ultimately regulating the cellular level of c-Myc. We sho...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Masui K,Tanaka K,Akhavan D,Babic I,Gini B,Matsutani T,Iwanami A,Liu F,Villa GR,Gu Y,Campos C,Zhu S,Yang H,Yong WH,Cloughesy TF,Mellinghoff IK,Cavenee WK,Shaw RJ,Mischel PS

    更新日期:2013-11-05 00:00:00

  • Mast Cell-Derived Histamine Regulates Liver Ketogenesis via Oleoylethanolamide Signaling.

    abstract::The conversion of lipolysis-derived fatty acids into ketone bodies (ketogenesis) is a crucial metabolic adaptation to prolonged periods of food scarcity. The process occurs primarily in liver mitochondria and is initiated by fatty-acid-mediated stimulation of the ligand-operated transcription factor, peroxisome prolif...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Misto A,Provensi G,Vozella V,Passani MB,Piomelli D

    更新日期:2019-01-08 00:00:00

  • Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation.

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    journal_title:Cell metabolism

    pub_type: 杂志文章


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  • PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.

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    journal_title:Cell metabolism

    pub_type: 杂志文章


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  • Mapping out starvation responses.

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    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Ashrafi K

    更新日期:2006-04-01 00:00:00

  • Metabolic Effects of Dietary Nitrate in Health and Disease.

    abstract::Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic signaling molecule involved in cardiovascular and metabolic regulation. More recently, an alternative pathway for the formation of this free radical has been explored. The inorganic anions nitrate (NO3-) and nitrite (NO2-), origi...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Lundberg JO,Carlström M,Weitzberg E

    更新日期:2018-07-03 00:00:00

  • Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance.

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    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Rubio-Patiño C,Bossowski JP,De Donatis GM,Mondragón L,Villa E,Aira LE,Chiche J,Mhaidly R,Lebeaupin C,Marchetti S,Voutetakis K,Chatziioannou A,Castelli FA,Lamourette P,Chu-Van E,Fenaille F,Avril T,Passeron T,Patterson

    更新日期:2018-04-03 00:00:00

  • Enriching the Circadian Proteome.

    abstract::Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Takahashi JS

    更新日期:2017-01-10 00:00:00

  • The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

    abstract::Peroxisome proliferator-activated receptor gamma coactivator-1 beta (PGC-1beta) is known to be a transcriptional coactivator for SREBP-1, the master regulator of hepatic lipogenesis. Here, we evaluated the role of PGC-1beta in the pathogenesis of fructose-induced insulin resistance by using an antisense oligonucletoid...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Nagai Y,Yonemitsu S,Erion DM,Iwasaki T,Stark R,Weismann D,Dong J,Zhang D,Jurczak MJ,Löffler MG,Cresswell J,Yu XX,Murray SF,Bhanot S,Monia BP,Bogan JS,Samuel V,Shulman GI

    更新日期:2009-03-01 00:00:00

  • Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans.

    abstract::Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Chen KY,Cypess AM,Laughlin MR,Haft CR,Hu HH,Bredella MA,Enerbäck S,Kinahan PE,Lichtenbelt Wv,Lin FI,Sunderland JJ,Virtanen KA,Wahl RL

    更新日期:2016-08-09 00:00:00

  • Mitohormesis.

    abstract::For many years, mitochondria were viewed as semiautonomous organelles, required only for cellular energetics. This view has been largely supplanted by the concept that mitochondria are fully integrated into the cell and that mitochondrial stresses rapidly activate cytosolic signaling pathways that ultimately alter nuc...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Yun J,Finkel T

    更新日期:2014-05-06 00:00:00

  • Can exercise mimetics substitute for exercise?

    abstract::Exercise leads to changes in muscle phenotype with important implications for exercise performance and health. A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Richter EA,Kiens B,Wojtaszewski JF

    更新日期:2008-08-01 00:00:00

  • Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.

    abstract::Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are not completely understood. We demonstrate that TNFalpha signaling through TNF receptor (TNFR) 1 suppresses AMPK activity via transcriptional upregulation o...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Steinberg GR,Michell BJ,van Denderen BJ,Watt MJ,Carey AL,Fam BC,Andrikopoulos S,Proietto J,Görgün CZ,Carling D,Hotamisligil GS,Febbraio MA,Kay TW,Kemp BE

    更新日期:2006-12-01 00:00:00

  • Setting the tone: reactive oxygen species and the control of appetitive melanocortin neurons.

    abstract::The brain melanocortin system is a primary gateway through which energy balance is controlled. Diano and colleagues report a novel cellular mechanism mediated via reactive oxygen species (ROS) that regulates the activity of these melanocortin neurons in response to energy status, thereby modulating appetitive behavior...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Rochford JJ,Myers MG Jr,Heisler LK

    更新日期:2011-11-02 00:00:00

  • The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity.

    abstract::Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However, how cold activates type 2 immunity in WAT remains obscure. Here we show that cold-induced type 2 immune responses and beiging in subcutaneous WAT (scWAT) are abro...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Huang Z,Zhong L,Lee JTH,Zhang J,Wu D,Geng L,Wang Y,Wong CM,Xu A

    更新日期:2017-09-05 00:00:00

  • Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle.

    abstract::Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN prote...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Sanders MA,Madoux F,Mladenovic L,Zhang H,Ye X,Angrish M,Mottillo EP,Caruso JA,Halvorsen G,Roush WR,Chase P,Hodder P,Granneman JG

    更新日期:2015-11-03 00:00:00

  • Physiological and Molecular Dissection of Daily Variance in Exercise Capacity.

    abstract::Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity betwee...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Ezagouri S,Zwighaft Z,Sobel J,Baillieul S,Doutreleau S,Ladeuix B,Golik M,Verges S,Asher G

    更新日期:2019-07-02 00:00:00

  • Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

    abstract::"Beige" adipocytes reside in white adipose tissue (WAT) and dissipate energy as heat. Several studies have shown that cold temperature can activate pro-opiomelanocortin-expressing (POMC) neurons and increase sympathetic neuronal tone to regulate WAT beiging. WAT, however, is traditionally known to be sparsely innervat...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Zhu Y,Gao Y,Tao C,Shao M,Zhao S,Huang W,Yao T,Johnson JA,Liu T,Cypess AM,Gupta O,Holland WL,Gupta RK,Spray DC,Tanowitz HB,Cao L,Lynes MD,Tseng YH,Elmquist JK,Williams KW,Lin HV,Scherer PE

    更新日期:2016-09-13 00:00:00

  • Hypothalamic tanycytes: gatekeepers to metabolic control.

    abstract::How circulating signals of hunger and satiety enter the brain to reach neurons that govern energy balance has long remained a matter of controversy and speculation. Balland et al. (2014) now elucidate molecular mechanisms by which a highly specialized hypothalamic glial cell regulates transport of leptin across the bl...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Gao Y,Tschöp MH,Luquet S

    更新日期:2014-02-04 00:00:00

  • Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness.

    abstract::Mitochondria undergo architectural/functional changes in response to metabolic inputs. How this process is regulated in physiological feeding/fasting states remains unclear. Here we show that mitochondrial dynamics (notably fission and mitophagy) and biogenesis are transcriptional targets of the circadian regulator Bm...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Jacobi D,Liu S,Burkewitz K,Kory N,Knudsen NH,Alexander RK,Unluturk U,Li X,Kong X,Hyde AL,Gangl MR,Mair WB,Lee CH

    更新日期:2015-10-06 00:00:00

  • An Emerging Technology Framework for the Neurobiology of Appetite.

    abstract::Advances in neuro-technology for mapping, manipulating, and monitoring molecularly defined cell types are rapidly advancing insight into neural circuits that regulate appetite. Here, we review these important tools and their applications in circuits that control food seeking and consumption. Technical capabilities pro...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Sternson SM,Atasoy D,Betley JN,Henry FE,Xu S

    更新日期:2016-02-09 00:00:00