Abstract:
:Dietary lipid digestion is critical for body fat storage control, but little is known about the regulation of genes involved in fat breakdown and absorption in the gastrointestinal tract. A Drosophila study (Sieber and Thummel, 2009 [this issue of Cell Metabolism]) now demonstrates that the orphan nuclear receptor DHR96 adjusts fat storage in flies by tuning gastric lipase expression.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Kühnlein RPdoi
10.1016/j.cmet.2009.11.004subject
Has Abstractpub_date
2009-12-01 00:00:00pages
438-9issue
6eissn
1550-4131issn
1932-7420pii
S1550-4131(09)00341-6journal_volume
10pub_type
评论,杂志文章相关文献
Cell Metabolism文献大全abstract::XBP1 is a key regulator of the unfolded protein response (UPR), which is involved in a wide range of physiological and pathological processes. XBP1 ablation in liver causes profound hypolipidemia in mice, highlighting its critical role in lipid metabolism. XBP1 deficiency triggers feedback activation of its upstream e...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.09.004
更新日期:2012-10-03 00:00:00
abstract::Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN prote...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.08.023
更新日期:2015-11-03 00:00:00
abstract::Cancer cells frequently hijack normal metabolic pathways to promote their growth and metastasis. Two recent papers by Knott et al. (2018) and Pavlova et al. (2018) demonstrate that asparagine and glutamine work in concert to drive tumor growth and metastasis through modulation of cell survival, growth, and EMT regulat...
journal_title:Cell metabolism
pub_type: 评论
doi:10.1016/j.cmet.2018.04.012
更新日期:2018-05-01 00:00:00
abstract::Diabetes is a growing epidemic, and many patients depend on insulin injections to control the disease and minimize long-term complications. In a recent manuscript published in Science, Xie et al. (2016) generate insulin-producing cells from a somatic embryonic kidney cell line through minimal genetic modification capa...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2017.01.018
更新日期:2017-02-07 00:00:00
abstract::Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycer...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2008.02.002
更新日期:2008-03-01 00:00:00
abstract::In this issue of Cell Metabolism, Mounier et al. (2013) show that AMPKα1 is a crucial contributor to the regeneration of damaged muscle tissues, acting in macrophages at the nexus between proinflammatory debris removal and resolution of muscle tissue inflammation. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2013.07.011
更新日期:2013-08-06 00:00:00
abstract::miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression and the function of...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2019.07.011
更新日期:2019-10-01 00:00:00
abstract::The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here, we show that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues. In the inguinal depot, cold exposure resulted in elevated expression levels of brown-fat-ass...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.11.009
更新日期:2009-01-07 00:00:00
abstract::Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lip...
journal_title:Cell metabolism
pub_type: 信件
doi:10.1016/j.cmet.2019.05.014
更新日期:2019-07-02 00:00:00
abstract::The "Rosies" of Cell Metabolism are back for the third part of the "Women in Metabolism" 2015 series. We are closing our anniversary celebrations with 14 inspiring and engaging new stories from women scientists in the metabolism field. A round of applause to all who contributed and supported this project! ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.11.005
更新日期:2015-12-01 00:00:00
abstract::Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.02.012
更新日期:2020-04-07 00:00:00
abstract::Plasticity in growth and reproductive behavior is found in many vertebrate species, but is common in male teleost fish. Typically, "bourgeois" males are considerably larger and defend breeding territories while "parasitic" variants are small and use opportunistic breeding strategies. The P locus mediates this phenotyp...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.12.014
更新日期:2012-02-08 00:00:00
abstract::Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes in the gut microbiota appear to be important. The inhibitory role of mic...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.07.012
更新日期:2020-10-06 00:00:00
abstract::Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.12.013
更新日期:2016-01-12 00:00:00
abstract::Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3 was shown to promote the expression of autophagy-related genes in skeletal muscle, the mechanisms triggering autophagy are unclear. We show that TSC1-deficient m...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.03.015
更新日期:2013-05-07 00:00:00
abstract::Nutritional and pharmacological stimuli can dramatically alter the cellular phenotypes in white adipose tissue (WAT). Utilizing genetic lineage tracing techniques, we demonstrate that brown adipocytes (BA) that are induced by β3-adrenergic receptor activation in abdominal WAT arise from the proliferation and different...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.03.009
更新日期:2012-04-04 00:00:00
abstract::The circadian clock is a ubiquitous timekeeping system that organizes the behavior and physiology of organisms over the day and night. Current models rely on transcriptional networks that coordinate circadian gene expression of thousands of transcripts. However, recent studies have uncovered phylogenetically conserved...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.07.024
更新日期:2016-09-13 00:00:00
abstract::Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in g...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.04.005
更新日期:2009-05-01 00:00:00
abstract::Factor inhibiting HIF-1alpha (FIH) is an asparaginyl hydroxylase. Hydroxylation of HIF-alpha proteins by FIH blocks association of HIFs with the transcriptional coactivators CBP/p300, thus inhibiting transcriptional activation. We have created mice with a null mutation in the FIH gene and found that it has little or n...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.03.001
更新日期:2010-05-05 00:00:00
abstract::Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and c...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.10.005
更新日期:2007-11-01 00:00:00
abstract::Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2017.06.019
更新日期:2017-07-05 00:00:00
abstract::Cyclic AMP (cAMP) and Ca(2+) are key regulators of exocytosis in many cells, including insulin-secreting beta cells. Glucose-stimulated insulin secretion from beta cells is pulsatile and involves oscillations of the cytoplasmic Ca(2+) concentration ([Ca(2+)](i)), but little is known about the detailed kinetics of cAMP...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.06.003
更新日期:2008-07-01 00:00:00
abstract::Obesity-related morbidity and mortality are related to fat accumulation and fat distribution in humans. Two large-scale meta-analyses recently published in Nature by Shungin et al. (2015) and Locke et al. (2015) report novel genetic associations for central and overall obesity; these greatly advance our understanding ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.03.016
更新日期:2015-04-07 00:00:00
abstract::In obesity, insulin resistance is linked to inflammation in several tissues. Although the gut is a very large lymphoid tissue, inflammation in the absorptive small intestine, the jejunum, where insulin regulates lipid and sugar absorption is unknown. We analyzed jejunal samples of 185 obese subjects stratified in thre...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.05.020
更新日期:2015-07-07 00:00:00
abstract::Mutations of mtDNA cause mitochondrial diseases and are implicated in age-associated diseases and aging. Pathogenic mtDNA mutations are often present in a fraction of all mtDNA copies, and it has been widely debated whether the proportion of mutant genomes or the absolute number of wild-type molecules determines if ox...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2017.07.003
更新日期:2017-08-01 00:00:00
abstract::Most animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in mediating the physiological effects of vagal activation. Here, we tested the hypo...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2006.09.008
更新日期:2006-11-01 00:00:00
abstract::Type 2 diabetes is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. Previous studies using a candidate gene approach, family linkage studies, and gene expression profiling uncov...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2008.08.006
更新日期:2008-09-01 00:00:00
abstract::The basis for region-specific neuronal toxicity in Huntington disease is unknown. Here, we show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes. Glucose is low in HdhQ(150/150) animals, and astrocytes in each brain region adapt by metabolically reprogramming their mitochondria ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.03.004
更新日期:2019-06-04 00:00:00
abstract::Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.02.011
更新日期:2015-03-03 00:00:00
abstract::Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity betwee...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.03.012
更新日期:2019-07-02 00:00:00