Abstract：
:Factor inhibiting HIF-1alpha (FIH) is an asparaginyl hydroxylase. Hydroxylation of HIF-alpha proteins by FIH blocks association of HIFs with the transcriptional coactivators CBP/p300, thus inhibiting transcriptional activation. We have created mice with a null mutation in the FIH gene and found that it has little or no discernable role in mice in altering classical aspects of HIF function, e.g., angiogenesis, erythropoiesis, or development. Rather, it is an essential regulator of metabolism: mice lacking FIH exhibit reduced body weight, elevated metabolic rate, hyperventilation, and improved glucose and lipid homeostasis and are resistant to high-fat-diet-induced weight gain and hepatic steatosis. Neuron-specific loss of FIH phenocopied some of the major metabolic phenotypes of the global null animals: those mice have reduced body weight, increased metabolic rate, and enhanced insulin sensitivity and are also protected against high-fat-diet-induced weight gain. These results demonstrate that FIH acts to a significant degree through the nervous system to regulate metabolism.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Zhang N,Fu Z,Linke S,Chicher J,Gorman JJ,Visk D,Haddad GG,Poellinger L,Peet DJ,Powell F,Johnson RSdoi
10.1016/j.cmet.2010.03.001subject
Has Abstractpub_date
2010-05-05 00:00:00pages
364-78issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(10)00069-0journal_volume
11pub_type
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