Women in Metabolism: Part 3.

Abstract:

:The "Rosies" of Cell Metabolism are back for the third part of the "Women in Metabolism" 2015 series. We are closing our anniversary celebrations with 14 inspiring and engaging new stories from women scientists in the metabolism field. A round of applause to all who contributed and supported this project!

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Ashcroft F,Pearce E,Partridge L,Suomalainen A,Brunet A,Schulze A,Tseng YH,Sethi JK,Reue K,Kingwell B,McNally E,Cnop M,Hevener AL,Diano S

doi

10.1016/j.cmet.2015.11.005

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

949-53

issue

6

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(15)00572-0

journal_volume

22

pub_type

杂志文章
  • Light activates the adrenal gland: timing of gene expression and glucocorticoid release.

    abstract::Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to improve metabolic and hormonal status of circadian rhythm sleep disorders, although its mechanism is poorly understood. In the present study, we revealed that light induces gene expression in the adrenal gland via the supra...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2005.09.009

    authors: Ishida A,Mutoh T,Ueyama T,Bando H,Masubuchi S,Nakahara D,Tsujimoto G,Okamura H

    更新日期:2005-11-01 00:00:00

  • HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.

    abstract::Glucagon drives hepatic gluconeogenesis and maintains blood glucose levels during fasting. The mechanism that attenuates glucagon action following refeeding is not understood. The present study demonstrates an increase in perivenous liver hypoxia immediately after feeding, which stabilizes hypoxia-inducible factor 2α ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.01.004

    authors: Ramakrishnan SK,Zhang H,Takahashi S,Centofanti B,Periyasamy S,Weisz K,Chen Z,Uhler MD,Rui L,Gonzalez FJ,Shah YM

    更新日期:2016-03-08 00:00:00

  • Conserved metabolic regulatory functions of sirtuins.

    abstract::Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2007.11.006

    authors: Schwer B,Verdin E

    更新日期:2008-02-01 00:00:00

  • Branching out for detection of type 2 diabetes.

    abstract::Type 2 diabetes is an epidemic disease worldwide, but it is difficult to predict its appearance in the general population. A recent study demonstrates that circulating concentrations of a small group of essential amino acids predict risk for diabetes, contributing to a recent resurgence of interest in these common ana...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2011.04.003

    authors: Shah SH,Svetkey LP,Newgard CB

    更新日期:2011-05-04 00:00:00

  • Insulin resistance in the defense against obesity.

    abstract::In the face of the current obesity epidemic, the nature of the relationship between overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state of excessive insulin action that elicits a series of cellular homeostatic responses, producing systemic insulin resistance. These responses occ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2012.03.001

    authors: Saltiel AR

    更新日期:2012-06-06 00:00:00

  • Type 1 Diabetes and MicroRNA: It's Complicated.

    abstract::Type 1 diabetes is an autoimmune disease that manifests as impaired insulin secretion, with compounding complications over time. Bhatt et al. (2015) investigate protective mechanisms in survivors of type 1 diabetes by using induced pluripotent stem cells as genetic models, uncovering novel interactions between microRN...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2015.07.018

    authors: Warren CR,Cowan CA

    更新日期:2015-08-04 00:00:00

  • Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

    abstract::Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of Socs-3, or those with neuronal deletion of Socs-3, are lean and more leptin and insulin sensitive. To examine the role of Socs-3 within...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2006.06.010

    authors: Kievit P,Howard JK,Badman MK,Balthasar N,Coppari R,Mori H,Lee CE,Elmquist JK,Yoshimura A,Flier JS

    更新日期:2006-08-01 00:00:00

  • Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion.

    abstract::Cyclic AMP (cAMP) and Ca(2+) are key regulators of exocytosis in many cells, including insulin-secreting beta cells. Glucose-stimulated insulin secretion from beta cells is pulsatile and involves oscillations of the cytoplasmic Ca(2+) concentration ([Ca(2+)](i)), but little is known about the detailed kinetics of cAMP...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2008.06.003

    authors: Dyachok O,Idevall-Hagren O,Sågetorp J,Tian G,Wuttke A,Arrieumerlou C,Akusjärvi G,Gylfe E,Tengholm A

    更新日期:2008-07-01 00:00:00

  • The Limits of Exercise Physiology: From Performance to Health.

    abstract::Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have been informed by stu...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2017.04.018

    authors: Gabriel BM,Zierath JR

    更新日期:2017-05-02 00:00:00

  • CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance.

    abstract::The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB(1)) has been shown to reduce body weight and to alleviate obesity-related metabolic disorders. An unsolved question is at which anatomical level CB(1) modulates energy balance ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2010.02.015

    authors: Quarta C,Bellocchio L,Mancini G,Mazza R,Cervino C,Braulke LJ,Fekete C,Latorre R,Nanni C,Bucci M,Clemens LE,Heldmaier G,Watanabe M,Leste-Lassere T,Maitre M,Tedesco L,Fanelli F,Reuss S,Klaus S,Srivastava RK,Monory K

    更新日期:2010-04-07 00:00:00

  • Enriching the Circadian Proteome.

    abstract::Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2016.12.014

    authors: Takahashi JS

    更新日期:2017-01-10 00:00:00

  • Adipose Dendritic Cells Come Out of Hiding.

    abstract::In this issue of Cell Metabolism, Macdougall et al. (2018) identify two subsets of conventional dendritic cells in visceral adipose tissue and demonstrate that these subsets engage distinct adipocyte-associated signaling pathways to drive their tolerogenic phenotypes in the lean state. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2018.02.014

    authors: LaMarche NM,Lynch L

    更新日期:2018-03-06 00:00:00

  • Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1β.

    abstract::Postprandial hypoglycemia is a disabling complication of the treatment of obesity by gastric bypass surgery. So far, no therapy exists, and the underlying mechanisms remain unclear. Here, we hypothesized that glucose-induced IL-1β leads to an exaggerated insulin response in this condition. Therefore, we conducted a pl...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.02.013

    authors: Hepprich M,Wiedemann SJ,Schelker BL,Trinh B,Stärkle A,Geigges M,Löliger J,Böni-Schnetzler M,Rudofsky G,Donath MY

    更新日期:2020-04-07 00:00:00

  • Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors.

    abstract::Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycer...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2008.02.002

    authors: Friedman SL,Nieto N

    更新日期:2008-03-01 00:00:00

  • Metabolic switches linked to pluripotency and embryonic stem cell differentiation.

    abstract::Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2015.02.011

    authors: Shyh-Chang N,Daley GQ

    更新日期:2015-03-03 00:00:00

  • Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.

    abstract::Virus infections trigger metabolic changes in host cells that support the bioenergetic and biosynthetic demands of viral replication. Although recent studies have characterized virus-induced changes in host cell metabolism (Munger et al., 2008; Terry et al., 2012), the molecular mechanisms by which viruses reprogram c...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2014.03.009

    authors: Thai M,Graham NA,Braas D,Nehil M,Komisopoulou E,Kurdistani SK,McCormick F,Graeber TG,Christofk HR

    更新日期:2014-04-01 00:00:00

  • Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN.

    abstract::Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the contr...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2013.01.006

    authors: Shi YC,Lau J,Lin Z,Zhang H,Zhai L,Sperk G,Heilbronn R,Mietzsch M,Weger S,Huang XF,Enriquez RF,Baldock PA,Zhang L,Sainsbury A,Herzog H,Lin S

    更新日期:2013-02-05 00:00:00

  • TOR signaling and S6 kinase 1: Yeast catches up.

    abstract::Conservation of the rapamycin-sensitive TOR signaling network among eukaryotes has been instrumental to the rapid progress made in this field in recent years. A recent report in Molecular Cell (Urban et al., 2007) now extends this conservation to include Sch9, an AGC protein kinase family member from S. cerevisiae, wh...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.cmet.2007.06.009

    authors: Powers T

    更新日期:2007-07-01 00:00:00

  • Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.

    abstract::Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and skeletal muscle, which shares a common progenitor with BAT, are dramatically decreased in mice placed on a high-fat diet and in obese humans. Expressio...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2012.11.005

    authors: Derecka M,Gornicka A,Koralov SB,Szczepanek K,Morgan M,Raje V,Sisler J,Zhang Q,Otero D,Cichy J,Rajewsky K,Shimoda K,Poli V,Strobl B,Pellegrini S,Harris TE,Seale P,Russell AP,McAinch AJ,O'Brien PE,Keller SR,Cronig

    更新日期:2012-12-05 00:00:00

  • CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.

    abstract::Signaling by the corticotropin-releasing factor receptor type 1 (CRFR1) plays an important role in mediating the autonomic response to stressful challenges. Multiple hypothalamic nuclei regulate sympathetic outflow. Although CRFR1 is highly expressed in the arcuate nucleus (Arc) of the hypothalamus, the identity of th...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.04.017

    authors: Kuperman Y,Weiss M,Dine J,Staikin K,Golani O,Ramot A,Nahum T,Kühne C,Shemesh Y,Wurst W,Harmelin A,Deussing JM,Eder M,Chen A

    更新日期:2016-06-14 00:00:00

  • SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice.

    abstract::Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD(+) biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in mammals. However, the significance of eNAMPT secretion remains unclear. Here we demonstrate that deacetylation of iNAMPT by the mammalian NAD(+)-dependent deacet...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.04.002

    authors: Yoon MJ,Yoshida M,Johnson S,Takikawa A,Usui I,Tobe K,Nakagawa T,Yoshino J,Imai S

    更新日期:2015-05-05 00:00:00

  • Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.

    abstract::Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.02.012

    authors: Ducrocq F,Walle R,Contini A,Oummadi A,Caraballo B,van der Veldt S,Boyer ML,Aby F,Tolentino-Cortez T,Helbling JC,Martine L,Grégoire S,Cabaret S,Vancassel S,Layé S,Kang JX,Fioramonti X,Berdeaux O,Barreda-Gómez G,Masso

    更新日期:2020-04-07 00:00:00

  • The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis.

    abstract::Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Pemt(-/-) mice fed a choline-deficient (CD) diet develop rapid steatohepatitis ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2006.03.007

    authors: Li Z,Agellon LB,Allen TM,Umeda M,Jewell L,Mason A,Vance DE

    更新日期:2006-05-01 00:00:00

  • Mast Cell-Derived Histamine Regulates Liver Ketogenesis via Oleoylethanolamide Signaling.

    abstract::The conversion of lipolysis-derived fatty acids into ketone bodies (ketogenesis) is a crucial metabolic adaptation to prolonged periods of food scarcity. The process occurs primarily in liver mitochondria and is initiated by fatty-acid-mediated stimulation of the ligand-operated transcription factor, peroxisome prolif...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.09.014

    authors: Misto A,Provensi G,Vozella V,Passani MB,Piomelli D

    更新日期:2019-01-08 00:00:00

  • The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis.

    abstract::Signaling cascades during adipogenesis culminate in the expression of two essential adipogenic factors, PPARgamma and C/EBPalpha. Here we demonstrate that the IRE1alpha-XBP1 pathway, the most conserved branch of the unfolded protein response (UPR), is indispensable for adipogenesis. Indeed, XBP1-deficient mouse embryo...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2009.04.009

    authors: Sha H,He Y,Chen H,Wang C,Zenno A,Shi H,Yang X,Zhang X,Qi L

    更新日期:2009-06-01 00:00:00

  • Macrophage autophagy plays a protective role in advanced atherosclerosis.

    abstract::In advanced atherosclerosis, macrophage apoptosis coupled with defective phagocytic clearance of the apoptotic cells (efferocytosis) promotes plaque necrosis, which precipitates acute atherothrombotic cardiovascular events. Oxidative and endoplasmic reticulum (ER) stress in macrophages are important causes of advanced...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2012.01.022

    authors: Liao X,Sluimer JC,Wang Y,Subramanian M,Brown K,Pattison JS,Robbins J,Martinez J,Tabas I

    更新日期:2012-04-04 00:00:00

  • Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.

    abstract::PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate that whole body deletion of Ptpmt1 in mice leads to embryonic lethality, suggesting an indispensable role for PTPMT1 during development. Ptpmt1 deficiency in mouse embr...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2011.04.007

    authors: Zhang J,Guan Z,Murphy AN,Wiley SE,Perkins GA,Worby CA,Engel JL,Heacock P,Nguyen OK,Wang JH,Raetz CR,Dowhan W,Dixon JE

    更新日期:2011-06-08 00:00:00

  • Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.

    abstract::Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur exclusively via the replication of existing beta cells, but clinically meaningful restoration of human beta cell mass by proliferation has never been achieved. We discovered a population of immature beta cells that is present through...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.03.017

    authors: van der Meulen T,Mawla AM,DiGruccio MR,Adams MW,Nies V,Dólleman S,Liu S,Ackermann AM,Cáceres E,Hunter AE,Kaestner KH,Donaldson CJ,Huising MO

    更新日期:2017-04-04 00:00:00

  • Causes, Characteristics, and Consequences of Metabolically Unhealthy Normal Weight in Humans.

    abstract::A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (∼20% of th...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2017.07.008

    authors: Stefan N,Schick F,Häring HU

    更新日期:2017-08-01 00:00:00

  • Movin' on up: adipocytes become regulators of nutrient homeostasis.

    abstract::By locally infecting epididymal adipocytes of obese diabetic mice with the uncoupling protein-1 transgene, Yamada et al. (2006[this issue of Cell Metabolism]) unexpectedly induce leptin sensitivity with hypophagia and improvement in abnormal glucose and lipid abnormalities. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2006.02.005

    authors: Unger RH,Elmquist JK

    更新日期:2006-03-01 00:00:00