Abstract：
:Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Pemt(-/-) mice fed a choline-deficient (CD) diet develop rapid steatohepatitis leading to liver failure. Steatosis is observed in CD mice that lack both PEMT and multiple drug-resistant protein 2 (MDR2), required for PC secretion into bile. We demonstrate that liver failure in CD-Pemt(-/-) mice is due to loss of membrane integrity caused by a decreased PC/PE ratio. The CD-Mdr2(-/-)/Pemt(-/-) mice escape liver failure by maintaining a normal PC/PE ratio. Manipulation of PC/PE levels suggests that this ratio is a key regulator of cell membrane integrity and plays a role in the progression of steatosis into steatohepatitis. The results have clinical implications as patients with nonalcoholic steatohepatitis have a decreased ratio of PC to PE compared to control livers.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Li Z,Agellon LB,Allen TM,Umeda M,Jewell L,Mason A,Vance DEdoi
10.1016/j.cmet.2006.03.007subject
Has Abstractpub_date
2006-05-01 00:00:00pages
321-31issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(06)00116-1journal_volume
3pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract：:Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2015.02.011
更新日期：2015-03-03 00:00:00
abstract：:Factor inhibiting HIF-1alpha (FIH) is an asparaginyl hydroxylase. Hydroxylation of HIF-alpha proteins by FIH blocks association of HIFs with the transcriptional coactivators CBP/p300, thus inhibiting transcriptional activation. We have created mice with a null mutation in the FIH gene and found that it has little or n...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.03.001
更新日期：2010-05-05 00:00:00
abstract：:The brain melanocortin system is a primary gateway through which energy balance is controlled. Diano and colleagues report a novel cellular mechanism mediated via reactive oxygen species (ROS) that regulates the activity of these melanocortin neurons in response to energy status, thereby modulating appetitive behavior...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2011.10.004
更新日期：2011-11-02 00:00:00
abstract：:The trace element copper (Cu) is a cofactor for biochemical functions ranging from energy generation to iron (Fe) acquisition, angiogenesis, and free radical detoxification. While Cu is essential for life, the molecules that mediate dietary Cu uptake have not been identified. Ctr1 is a homotrimeric protein, conserved ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.08.009
更新日期：2006-09-01 00:00:00
abstract：:Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria. Although these core enzymes are well studied, additional mitochondrial transporters and regulatory factors are predicted to be required. To discover such unkn...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.06.012
更新日期：2009-08-01 00:00:00
abstract：:Cholesteryl ester accumulation by macrophages is a critical early event in atherogenesis. To test the hypothesis that sterol loading promotes foam cell formation and vascular disease by perturbing a network of interacting proteins, we used a global approach to identify proteins that are differentially expressed when m...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.01.003
更新日期：2010-02-03 00:00:00
abstract：:Mutations of mtDNA cause mitochondrial diseases and are implicated in age-associated diseases and aging. Pathogenic mtDNA mutations are often present in a fraction of all mtDNA copies, and it has been widely debated whether the proportion of mutant genomes or the absolute number of wild-type molecules determines if ox...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.07.003
更新日期：2017-08-01 00:00:00
abstract：:The adult skeleton is constantly renewed through bone remodeling. Four recent papers (Baldock et al., 2007; Lee et al., 2007; Lundberg et al., 2007; Sato et al., 2007) provide new insights into central and peripheral control of this remodeling sequence. Two of the studies add to our knowledge of the complex hypothalam...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2007.12.004
更新日期：2008-01-01 00:00:00
abstract：:A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (∼20% of th...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2017.07.008
更新日期：2017-08-01 00:00:00
abstract：:In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent transcription factors (e.g., CLOCK...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2011.01.006
更新日期：2011-02-02 00:00:00
abstract：:Faced with changing food availability, organisms adapt metabolism to survive. In a recent issue of Cell, Lin et al. (2009) described the acetylation of an extranuclear enzyme being regulated by acetyl-CoA. This finding connects nutrient availability, energy status, and survival. ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.03.009
更新日期：2009-04-01 00:00:00
abstract：:Medial nucleus tractus solitarius (mNTS) neurons express leptin receptors (LepRs), and intra-mNTS delivery of leptin reduces food intake and body weight. Here, the contribution of endogenous LepR signaling in mNTS neurons to energy balance control was examined. Knockdown of LepR in mNTS and area postrema (AP) neurons ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.10.009
更新日期：2010-01-01 00:00:00
abstract：:The conversion of lipolysis-derived fatty acids into ketone bodies (ketogenesis) is a crucial metabolic adaptation to prolonged periods of food scarcity. The process occurs primarily in liver mitochondria and is initiated by fatty-acid-mediated stimulation of the ligand-operated transcription factor, peroxisome prolif...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.09.014
更新日期：2019-01-08 00:00:00
abstract：:Mitochondria are dynamic organelles that have been linked to stem cell homeostasis. However, the mechanisms involved in mitochondrial regulation of stem cell fate determination remain elusive. Here we discover that epithelial-mesenchymal transition (EMT), a key process in cancer progression, induces mitochondrial fusi...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.11.004
更新日期：2019-04-02 00:00:00
abstract：:Cellular metabolite balance and mitochondrial function are under circadian control, but the pathways connecting the molecular clock to these functions are unclear. Peroxisome proliferator-activated receptor delta (PPARδ) enables preferential utilization of lipids as fuel during exercise and is a major driver of exerci...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.06.002
更新日期：2017-07-05 00:00:00
abstract：:Advances in neuro-technology for mapping, manipulating, and monitoring molecularly defined cell types are rapidly advancing insight into neural circuits that regulate appetite. Here, we review these important tools and their applications in circuits that control food seeking and consumption. Technical capabilities pro...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2015.12.002
更新日期：2016-02-09 00:00:00
abstract：:In flies, ecdysone integrates growth with developmental transitions by antagonizing insulin signaling, which links growth with nutritional status. Work in Developmental Cell (Delanoue et. al, 2010) finds that ecdysone represses the transcription factor Myc in the larval fat body to inhibit systemic growth, revealing a...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.06.003
更新日期：2010-07-07 00:00:00
abstract：:Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic signaling molecule involved in cardiovascular and metabolic regulation. More recently, an alternative pathway for the formation of this free radical has been explored. The inorganic anions nitrate (NO3-) and nitrite (NO2-), origi...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2018.06.007
更新日期：2018-07-03 00:00:00
abstract：:SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availability. Here we show...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2011.03.004
更新日期：2011-04-06 00:00:00
abstract：:Almost always, obesity is an obligate prerequisite for the development of type 2 diabetes mellitus. Loss of a well-known lipid phosphatase appears to prevent insulin-resistant diabetes in mice by removal of a positive regulator of adiposity. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2005.01.007
更新日期：2005-02-01 00:00:00
abstract：:Circadian clocks, which underlie the daily rhythms in virtually all organisms, are entrained by diurnal changes in light, temperature, nutrients, and even sound. Simoni et al. (2014) demonstrate that diurnal variation in mechanical vibrations can reset circadian clock phase, providing a potential mechanism for integra...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2014.04.011
更新日期：2014-05-06 00:00:00
abstract：:You are what you eat; but when you eat also seems to be important for a healthy metabolism. In this issue of Cell Metabolism, Benegiamo et al. (2018) uncover a mechanism by which the RNA-binding protein NONO promotes the time-of-day-dependent expression of key metabolic genes at a post-transcriptional level in respons...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2018.01.009
更新日期：2018-02-06 00:00:00
abstract：:Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However, how cold activates type 2 immunity in WAT remains obscure. Here we show that cold-induced type 2 immune responses and beiging in subcutaneous WAT (scWAT) are abro...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.08.003
更新日期：2017-09-05 00:00:00
abstract：:Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The dense network of islet capillaries includes the islet pericyte, a cell that has barely been studied. Here we show that islet pericytes help control local blood flow by adjusting islet capillary diameter. Islet pericytes cove...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.02.016
更新日期：2018-03-06 00:00:00
abstract：:Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have been informed by stu...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2017.04.018
更新日期：2017-05-02 00:00:00
abstract：:The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB(1)) has been shown to reduce body weight and to alleviate obesity-related metabolic disorders. An unsolved question is at which anatomical level CB(1) modulates energy balance ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.02.015
更新日期：2010-04-07 00:00:00
abstract：:AS160 has emerged as a key player in insulin-mediated glucose transport through controlling GLUT4 trafficking, which is thought to be regulated by insulin-stimulated phosphorylation of sites including the 14-3-3 binding phospho-Thr649 (equivalent to Thr642 in human AS160). To define physiological roles of AS160-Thr649...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.12.005
更新日期：2011-01-05 00:00:00
abstract：:Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of Socs-3, or those with neuronal deletion of Socs-3, are lean and more leptin and insulin sensitive. To examine the role of Socs-3 within...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.06.010
更新日期：2006-08-01 00:00:00
abstract：:The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic ...
journal_title：Cell metabolism
pub_type： 临床试验,杂志文章
doi：10.1016/j.cmet.2017.02.009
更新日期：2017-03-07 00:00:00
abstract：:The ability of hormones such as insulin, leptin, and cholecystokinin to alter food intake is influenced by intricate interactions between homeostatic and non-homeostatic factors. Consequently, when administered exogenously, the likelihood of these hormones influencing food intake is probabilistic, leading to difficult...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.08.017
更新日期：2015-09-01 00:00:00
