Abstract：
:In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent transcription factors (e.g., CLOCK, NPAS2, and HSF1), nutrient-sensing transcriptional regulatory proteins (e.g., CREB-CBP-CRCT2, FOXO-p300, nuclear receptors, PGC-1, and SP1 family members) and protein kinases (e.g., AMPK), are plausible candidates for conveying a cell's metabolic state to the core clock circuitry. The intertwining between these acute regulators and circadian clock components is so tight that the discrimination between metabolic and circadian oscillations may be somewhat arbitrary.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Asher G,Schibler Udoi
10.1016/j.cmet.2011.01.006subject
Has Abstractpub_date
2011-02-02 00:00:00pages
125-37issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(11)00007-6journal_volume
13pub_type
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