The metabolic sensor GCN2 branches out.

Abstract:

:GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid deprivation.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Towle HC

doi

10.1016/j.cmet.2007.01.010

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

85-7

issue

2

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(07)00011-3

journal_volume

5

pub_type

评论,杂志文章
  • Movin' on up: adipocytes become regulators of nutrient homeostasis.

    abstract::By locally infecting epididymal adipocytes of obese diabetic mice with the uncoupling protein-1 transgene, Yamada et al. (2006[this issue of Cell Metabolism]) unexpectedly induce leptin sensitivity with hypophagia and improvement in abnormal glucose and lipid abnormalities. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2006.02.005

    authors: Unger RH,Elmquist JK

    更新日期:2006-03-01 00:00:00

  • Snapin mediates incretin action and augments glucose-dependent insulin secretion.

    abstract::Impaired insulin secretion contributes to the pathogenesis of type 2 diabetes mellitus (T2DM). Treatment with the incretin hormone glucagon-like peptide-1 (GLP-1) potentiates insulin secretion and improves metabolic control in humans with T2DM. GLP-1 receptor-mediated signaling leading to insulin secretion occurs via ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2011.02.002

    authors: Song WJ,Seshadri M,Ashraf U,Mdluli T,Mondal P,Keil M,Azevedo M,Kirschner LS,Stratakis CA,Hussain MA

    更新日期:2011-03-02 00:00:00

  • The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease.

    abstract::Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key componen...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2019.10.010

    authors: Kisseleva T,Brenner DA

    更新日期:2019-11-05 00:00:00

  • Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation.

    abstract::Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes in the gut microbiota appear to be important. The inhibitory role of mic...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2020.07.012

    authors: Koh A,Mannerås-Holm L,Yunn NO,Nilsson PM,Ryu SH,Molinaro A,Perkins R,Smith JG,Bäckhed F

    更新日期:2020-10-06 00:00:00

  • Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency.

    abstract::Most animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in mediating the physiological effects of vagal activation. Here, we tested the hypo...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2006.09.008

    authors: Gautam D,Gavrilova O,Jeon J,Pack S,Jou W,Cui Y,Li JH,Wess J

    更新日期:2006-11-01 00:00:00

  • Mitohormesis.

    abstract::For many years, mitochondria were viewed as semiautonomous organelles, required only for cellular energetics. This view has been largely supplanted by the concept that mitochondria are fully integrated into the cell and that mitochondrial stresses rapidly activate cytosolic signaling pathways that ultimately alter nuc...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2014.01.011

    authors: Yun J,Finkel T

    更新日期:2014-05-06 00:00:00

  • Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk.

    abstract::The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing ne...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2012.10.007

    authors: Holmes E,Li JV,Marchesi JR,Nicholson JK

    更新日期:2012-11-07 00:00:00

  • Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.

    abstract::Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulation at the transcriptional level, much less is known about tempor...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.10.003

    authors: Wang J,Mauvoisin D,Martin E,Atger F,Galindo AN,Dayon L,Sizzano F,Palini A,Kussmann M,Waridel P,Quadroni M,Dulić V,Naef F,Gachon F

    更新日期:2017-01-10 00:00:00

  • Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle.

    abstract::Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN prote...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.08.023

    authors: Sanders MA,Madoux F,Mladenovic L,Zhang H,Ye X,Angrish M,Mottillo EP,Caruso JA,Halvorsen G,Roush WR,Chase P,Hodder P,Granneman JG

    更新日期:2015-11-03 00:00:00

  • Sodium Intake Regulates Glucose Homeostasis through the PPARδ/Adiponectin-Mediated SGLT2 Pathway.

    abstract::High sodium intake is a major risk factor for developing hypertension in diabetes. Promotion of sodium excretion reduces cardiometabolic lesions in diabetes. However, the interaction between sodium intake and glucose homeostasis remains elusive. Here, we report that high sodium intake remarkably increased natriuresis ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2016.02.019

    authors: Zhao Y,Gao P,Sun F,Li Q,Chen J,Yu H,Li L,Wei X,He H,Lu Z,Wei X,Wang B,Cui Y,Xiong S,Shang Q,Xu A,Huang Y,Liu D,Zhu Z

    更新日期:2016-04-12 00:00:00

  • Enriching the Circadian Proteome.

    abstract::Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2016.12.014

    authors: Takahashi JS

    更新日期:2017-01-10 00:00:00

  • Obesity and FTO: Changing Focus at a Complex Locus.

    abstract::The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2014.09.010

    authors: Tung YCL,Yeo GSH,O'Rahilly S,Coll AP

    更新日期:2014-11-04 00:00:00

  • One-Carbon Metabolism in Health and Disease.

    abstract::One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid homeostasis (glycine, serine, and methionine), epigenetic maintenance, and redox defense. Both within eukaryotic cells and across organs, 1C metabolic r...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2016.08.009

    authors: Ducker GS,Rabinowitz JD

    更新日期:2017-01-10 00:00:00

  • Women in Metabolism: The Next Generation.

    abstract::The "Rosies" of Cell Metabolism persist as a new generation enters the stage. With inspiration from this issue's cover art, we celebrate young and diverse scientists and the mentorship that has guided them throughout. Their stories come from different corners of the world but are tied together by a common thread of te...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.08.021

    authors:

    更新日期:2017-09-05 00:00:00

  • Adipose Dendritic Cells Come Out of Hiding.

    abstract::In this issue of Cell Metabolism, Macdougall et al. (2018) identify two subsets of conventional dendritic cells in visceral adipose tissue and demonstrate that these subsets engage distinct adipocyte-associated signaling pathways to drive their tolerogenic phenotypes in the lean state. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2018.02.014

    authors: LaMarche NM,Lynch L

    更新日期:2018-03-06 00:00:00

  • The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity.

    abstract::Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However, how cold activates type 2 immunity in WAT remains obscure. Here we show that cold-induced type 2 immune responses and beiging in subcutaneous WAT (scWAT) are abro...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.08.003

    authors: Huang Z,Zhong L,Lee JTH,Zhang J,Wu D,Geng L,Wang Y,Wong CM,Xu A

    更新日期:2017-09-05 00:00:00

  • Leptin does not directly affect CNS serotonin neurons to influence appetite.

    abstract::Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not expres...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2011.03.016

    authors: Lam DD,Leinninger GM,Louis GW,Garfield AS,Marston OJ,Leshan RL,Scheller EL,Christensen L,Donato J Jr,Xia J,Evans ML,Elias C,Dalley JW,Burdakov DI,Myers MG Jr,Heisler LK

    更新日期:2011-05-04 00:00:00

  • FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.

    abstract::The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mice, we show that βK...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2014.07.012

    authors: Owen BM,Ding X,Morgan DA,Coate KC,Bookout AL,Rahmouni K,Kliewer SA,Mangelsdorf DJ

    更新日期:2014-10-07 00:00:00

  • Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load.

    abstract::Mutations of mtDNA cause mitochondrial diseases and are implicated in age-associated diseases and aging. Pathogenic mtDNA mutations are often present in a fraction of all mtDNA copies, and it has been widely debated whether the proportion of mutant genomes or the absolute number of wild-type molecules determines if ox...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.07.003

    authors: Jiang M,Kauppila TES,Motori E,Li X,Atanassov I,Folz-Donahue K,Bonekamp NA,Albarran-Gutierrez S,Stewart JB,Larsson NG

    更新日期:2017-08-01 00:00:00

  • Asparagine and Glutamine: Co-conspirators Fueling Metastasis.

    abstract::Cancer cells frequently hijack normal metabolic pathways to promote their growth and metastasis. Two recent papers by Knott et al. (2018) and Pavlova et al. (2018) demonstrate that asparagine and glutamine work in concert to drive tumor growth and metastasis through modulation of cell survival, growth, and EMT regulat...

    journal_title:Cell metabolism

    pub_type: 评论

    doi:10.1016/j.cmet.2018.04.012

    authors: Luo M,Brooks M,Wicha MS

    更新日期:2018-05-01 00:00:00

  • ERRγ-A New Player in β Cell Maturation.

    abstract::Glucose and hormone responsiveness of pancreatic β cells is acquired during postnatal maturation and is critical for appropriate insulin secretion. In a recent issue of Cell Metabolism, Yoshihara et al. (2016) report that estrogen-related receptor γ (ERRγ) promotes functional maturation of both mouse neonatal β cells ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2016.04.026

    authors: Shirakawa J,Kulkarni RN

    更新日期:2016-05-10 00:00:00

  • Insulin resistance in the defense against obesity.

    abstract::In the face of the current obesity epidemic, the nature of the relationship between overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state of excessive insulin action that elicits a series of cellular homeostatic responses, producing systemic insulin resistance. These responses occ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2012.03.001

    authors: Saltiel AR

    更新日期:2012-06-06 00:00:00

  • When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade.

    abstract::In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support c...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2017.11.008

    authors: Shan M,Lyssiotis CA

    更新日期:2017-12-05 00:00:00

  • Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.

    abstract::The canonical notion that type 1 diabetes (T1D) results following a complete destruction of β cells has recently been questioned as small amounts of C-peptide are detectable in patients with long-standing disease. We analyzed protein and gene expression levels for proinsulin, insulin, C-peptide, and islet amyloid poly...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.08.013

    authors: Wasserfall C,Nick HS,Campbell-Thompson M,Beachy D,Haataja L,Kusmartseva I,Posgai A,Beery M,Rhodes C,Bonifacio E,Arvan P,Atkinson M

    更新日期:2017-09-05 00:00:00

  • Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile.

    abstract::C. difficile infection is a deadly disease that is influenced by the microbiome. In a recent article in Nature, Buffie et al. (2014) demonstrate that the ability of C. scindens to synthesize secondary bile acids is crucial to providing resistance to C. difficile infection. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2014.12.016

    authors: Greathouse KL,Harris CC,Bultman SJ

    更新日期:2015-01-06 00:00:00

  • Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin.

    abstract::Mitochondria are dynamic organelles that have been linked to stem cell homeostasis. However, the mechanisms involved in mitochondrial regulation of stem cell fate determination remain elusive. Here we discover that epithelial-mesenchymal transition (EMT), a key process in cancer progression, induces mitochondrial fusi...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.11.004

    authors: Wu MJ,Chen YS,Kim MR,Chang CC,Gampala S,Zhang Y,Wang Y,Chang CY,Yang JY,Chang CJ

    更新日期:2019-04-02 00:00:00

  • The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

    abstract::Peroxisome proliferator-activated receptor gamma coactivator-1 beta (PGC-1beta) is known to be a transcriptional coactivator for SREBP-1, the master regulator of hepatic lipogenesis. Here, we evaluated the role of PGC-1beta in the pathogenesis of fructose-induced insulin resistance by using an antisense oligonucletoid...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2009.01.011

    authors: Nagai Y,Yonemitsu S,Erion DM,Iwasaki T,Stark R,Weismann D,Dong J,Zhang D,Jurczak MJ,Löffler MG,Cresswell J,Yu XX,Murray SF,Bhanot S,Monia BP,Bogan JS,Samuel V,Shulman GI

    更新日期:2009-03-01 00:00:00

  • Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.

    abstract::Incretin hormones exert pleiotropic metabolic actions beyond the pancreas. Although the heart expresses both incretin receptors, the cardiac biology of GIP receptor (GIPR) action remains incompletely understood. Here we show that GIPR agonism did not impair the response to cardiac ischemia. In contrast, genetic elimin...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2017.11.003

    authors: Ussher JR,Campbell JE,Mulvihill EE,Baggio LL,Bates HE,McLean BA,Gopal K,Capozzi M,Yusta B,Cao X,Ali S,Kim M,Kabir MG,Seino Y,Suzuki J,Drucker DJ

    更新日期:2018-02-06 00:00:00

  • Mealtime Is NONO Speckled: Timing Hepatic Adaptation to Food.

    abstract::You are what you eat; but when you eat also seems to be important for a healthy metabolism. In this issue of Cell Metabolism, Benegiamo et al. (2018) uncover a mechanism by which the RNA-binding protein NONO promotes the time-of-day-dependent expression of key metabolic genes at a post-transcriptional level in respons...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2018.01.009

    authors: Torres M,Kramer A

    更新日期:2018-02-06 00:00:00

  • Type 1 Diabetes and MicroRNA: It's Complicated.

    abstract::Type 1 diabetes is an autoimmune disease that manifests as impaired insulin secretion, with compounding complications over time. Bhatt et al. (2015) investigate protective mechanisms in survivors of type 1 diabetes by using induced pluripotent stem cells as genetic models, uncovering novel interactions between microRN...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2015.07.018

    authors: Warren CR,Cowan CA

    更新日期:2015-08-04 00:00:00