Abstract：
:The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic variants and FTO activity has remained elusive. Two recent reports now indicate that obesity-associated SNPs appear functionally connected not with FTO but with two neighboring genes: IRX3 and RPGRIP1L. Here, we review these new findings and consider the implications for future analysis of GWAS hits.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Tung YCL,Yeo GSH,O'Rahilly S,Coll APdoi
10.1016/j.cmet.2014.09.010subject
Has Abstractpub_date
2014-11-04 00:00:00pages
710-718issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(14)00407-0journal_volume
20pub_type
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