Abstract：
:Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
He L,Wondisford FEdoi
10.1016/j.cmet.2015.01.003subject
Has Abstractpub_date
2015-02-03 00:00:00pages
159-162issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(15)00004-2journal_volume
21pub_type
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