Abstract：
:Glia-neuron interactions underlie a number of homeostatic processes in the brain. In this issue of Cell Metabolism, Li et al. (2020) demonstrate that the regeneration of central nervous system axons is accelerated through modulation of neuronal GABA-B receptor activity by metabolic energy intermediaries released from glia.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Morrison BMdoi
10.1016/j.cmet.2020.10.009subject
Has Abstractpub_date
2020-11-03 00:00:00pages
695-696issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(20)30542-8journal_volume
32pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract：:CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or oxidative metabolic programs in vitro, requirements and mechanisms that control T cell glucose uptake and metabolism in viv...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.05.004
更新日期：2014-07-01 00:00:00
abstract：:RNA-targeted therapies represent a platform for drug discovery involving chemically modified oligonucleotides, a wide range of cellular RNAs, and a novel target-binding motif, Watson-Crick base pairing. Numerous hurdles considered by many to be impassable have been overcome. Today, four RNA-targeted therapies are appr...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2018.03.004
更新日期：2018-04-03 00:00:00
abstract：:Circadian clocks, which underlie the daily rhythms in virtually all organisms, are entrained by diurnal changes in light, temperature, nutrients, and even sound. Simoni et al. (2014) demonstrate that diurnal variation in mechanical vibrations can reset circadian clock phase, providing a potential mechanism for integra...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2014.04.011
更新日期：2014-05-06 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in Western societies, affecting one in four adults in the USA, and is strongly associated with hepatic insulin resistance, a major risk factor in the pathogenesis of type 2 diabetes. Although the cellular mechanisms underlying this...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2012.03.005
更新日期：2012-05-02 00:00:00
abstract：:Advances in neuro-technology for mapping, manipulating, and monitoring molecularly defined cell types are rapidly advancing insight into neural circuits that regulate appetite. Here, we review these important tools and their applications in circuits that control food seeking and consumption. Technical capabilities pro...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2015.12.002
更新日期：2016-02-09 00:00:00
abstract：:The brain melanocortin system is a primary gateway through which energy balance is controlled. Diano and colleagues report a novel cellular mechanism mediated via reactive oxygen species (ROS) that regulates the activity of these melanocortin neurons in response to energy status, thereby modulating appetitive behavior...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2011.10.004
更新日期：2011-11-02 00:00:00
abstract：:C. difficile infection is a deadly disease that is influenced by the microbiome. In a recent article in Nature, Buffie et al. (2014) demonstrate that the ability of C. scindens to synthesize secondary bile acids is crucial to providing resistance to C. difficile infection. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2014.12.016
更新日期：2015-01-06 00:00:00
abstract：:Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 mon...
journal_title：Cell metabolism
pub_type： 临床试验,杂志文章
doi：10.1016/j.cmet.2016.11.004
更新日期：2017-02-07 00:00:00
abstract：:Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates ...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2007.11.006
更新日期：2008-02-01 00:00:00
abstract：:Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, iden...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.05.010
更新日期：2020-06-02 00:00:00
abstract：:Humans exhibit remarkable interindividual variations in the concentration of small molecules found throughout the body, due in part to concurrent variations in each person's associated microbial communities. Recent studies have begun to uncover how microbes interface with their host during exposure to drugs, dietary c...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.07.002
更新日期：2014-11-04 00:00:00
abstract：:Cutting down calories prolongs life, but how this works remains largely unknown. A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2011.03.012
更新日期：2011-04-06 00:00:00
abstract：:The PAR-domain basic leucine zipper (PAR bZip) transcription factors DBP, TEF, and HLF accumulate in a highly circadian manner in several peripheral tissues, including liver and kidney. Mice devoid of all three of these proteins are born at expected Mendelian ratios, but are epilepsy prone, age at an accelerated rate,...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.04.015
更新日期：2006-07-01 00:00:00
abstract：:As a preview of the upcoming Cell Symposium on Exercise Metabolism in Gothenburg, Sweden, May 21-23 (http://cell-symposia.com/exercisemetabolism-2017/), several of our speakers and other Cell Press exercise enthusiasts share a wide range of experiences from bench pressing goals to bench research insights. ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.04.024
更新日期：2017-05-02 00:00:00
abstract：:Nutritional and pharmacological stimuli can dramatically alter the cellular phenotypes in white adipose tissue (WAT). Utilizing genetic lineage tracing techniques, we demonstrate that brown adipocytes (BA) that are induced by β3-adrenergic receptor activation in abdominal WAT arise from the proliferation and different...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.03.009
更新日期：2012-04-04 00:00:00
abstract：:Whether some hypothalamic neurons have direct access to circulating metabolic cues represents a crucial question that has been intensely debated. New findings reveal that fasting promotes "leakiness" of some hypothalamic blood vessels, increasing the access of circulating factors to certain hypothalamic neurons that c...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2013.03.007
更新日期：2013-04-02 00:00:00
abstract：:Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure. Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if lipolysis is important for future body weight gain and associated disturbed glucose metabolism, and this was presently investigated in ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.05.004
更新日期：2018-07-03 00:00:00
abstract：:Polg mtDNA mutator mice are important models for investigating the role of acquired mtDNA mutations in aging. Despite extensive study, there remains little consensus on either the etiology of the progeroid phenotype or the mtDNA mutation spectrum induced by disrupted polymerase-γ function. To investigate the latter, w...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.11.012
更新日期：2010-12-01 00:00:00
abstract：:For many years, mitochondria were viewed as semiautonomous organelles, required only for cellular energetics. This view has been largely supplanted by the concept that mitochondria are fully integrated into the cell and that mitochondrial stresses rapidly activate cytosolic signaling pathways that ultimately alter nuc...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2014.01.011
更新日期：2014-05-06 00:00:00
abstract：:In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation. ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.03.012
更新日期：2020-04-07 00:00:00
abstract：:Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2008.03.006
更新日期：2008-05-01 00:00:00
abstract：:The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are interlinked, opposing signaling pathways involved in sensing availability of nutrients and energy and regulation of cell growth. AMPK (Yin, or the "dark side") is switched on by lack of energy or nutrients and inhibits cell growth, whil...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2020.01.015
更新日期：2020-03-03 00:00:00
abstract：:Medial nucleus tractus solitarius (mNTS) neurons express leptin receptors (LepRs), and intra-mNTS delivery of leptin reduces food intake and body weight. Here, the contribution of endogenous LepR signaling in mNTS neurons to energy balance control was examined. Knockdown of LepR in mNTS and area postrema (AP) neurons ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.10.009
更新日期：2010-01-01 00:00:00
abstract：:Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) drives expression of genes regulating RCT, and its activity can be ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.07.023
更新日期：2014-10-07 00:00:00
abstract：:Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Pemt(-/-) mice fed a choline-deficient (CD) diet develop rapid steatohepatitis ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.03.007
更新日期：2006-05-01 00:00:00
abstract：:Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the contr...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2013.01.006
更新日期：2013-02-05 00:00:00
abstract：:Plasticity in growth and reproductive behavior is found in many vertebrate species, but is common in male teleost fish. Typically, "bourgeois" males are considerably larger and defend breeding territories while "parasitic" variants are small and use opportunistic breeding strategies. The P locus mediates this phenotyp...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2011.12.014
更新日期：2012-02-08 00:00:00
abstract：:In advanced atherosclerosis, macrophage apoptosis coupled with defective phagocytic clearance of the apoptotic cells (efferocytosis) promotes plaque necrosis, which precipitates acute atherothrombotic cardiovascular events. Oxidative and endoplasmic reticulum (ER) stress in macrophages are important causes of advanced...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.01.022
更新日期：2012-04-04 00:00:00
abstract：:Mammary epithelial cells transition between periods of proliferation and quiescence during development, menstrual cycles, and pregnancy, and as a result of oncogenic transformation. Utilizing an organotypic 3D tissue culture model coupled with quantitative metabolomics and proteomics, we identified significant differe...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.03.016
更新日期：2016-05-10 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse that we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.02.004
更新日期：2015-03-03 00:00:00
