A CRTCal link between energy and life span.

Abstract:

:Cutting down calories prolongs life, but how this works remains largely unknown. A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Brunet A

doi

10.1016/j.cmet.2011.03.012

subject

Has Abstract

pub_date

2011-04-06 00:00:00

pages

358-360

issue

4

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(11)00099-4

journal_volume

13

pub_type

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