Abstract:
:Phosphorylation of glycogen has been known for decades; however, the basic metabolic pathways responsible for this modification are unknown. In this issue, Tagliabracci et al. (2011) report the enzyme responsible for incorporating phosphate and the chemical nature of the phosphate linkage, providing a framework for expanding our understanding of a devastating form of epilepsy.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Worby CA,Dixon JEdoi
10.1016/j.cmet.2011.02.006subject
Has Abstractpub_date
2011-03-02 00:00:00pages
233-4issue
3eissn
1550-4131issn
1932-7420pii
S1550-4131(11)00050-7journal_volume
13pub_type
评论,杂志文章相关文献
Cell Metabolism文献大全abstract::Mitochondria are dynamic organelles that have been linked to stem cell homeostasis. However, the mechanisms involved in mitochondrial regulation of stem cell fate determination remain elusive. Here we discover that epithelial-mesenchymal transition (EMT), a key process in cancer progression, induces mitochondrial fusi...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.11.004
更新日期:2019-04-02 00:00:00
abstract::Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have been informed by stu...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2017.04.018
更新日期:2017-05-02 00:00:00
abstract::Despite the prevalence of obesity and its related diseases, the signaling pathways for appetite control and satiety are not clearly understood. Here we report C. elegans quiescence behavior, a cessation of food intake and movement that is possibly a result of satiety. C. elegans quiescence shares several characteristi...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.01.005
更新日期:2008-03-01 00:00:00
abstract::The interaction between the immune system and endocrine cells in the pancreas is crucial for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) enables multiplexed assessment of the abundance and localization of more than 30 proteins on the same tissue section at 1-μm resolution. Her...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.01.003
更新日期:2019-03-05 00:00:00
abstract::PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate that whole body deletion of Ptpmt1 in mice leads to embryonic lethality, suggesting an indispensable role for PTPMT1 during development. Ptpmt1 deficiency in mouse embr...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.04.007
更新日期:2011-06-08 00:00:00
abstract::Conservation of the rapamycin-sensitive TOR signaling network among eukaryotes has been instrumental to the rapid progress made in this field in recent years. A recent report in Molecular Cell (Urban et al., 2007) now extends this conservation to include Sch9, an AGC protein kinase family member from S. cerevisiae, wh...
journal_title:Cell metabolism
pub_type: 评论,杂志文章,评审
doi:10.1016/j.cmet.2007.06.009
更新日期:2007-07-01 00:00:00
abstract::Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.02.012
更新日期:2020-04-07 00:00:00
abstract::Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we demonstrate that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (BCSCs) and cancer chemoresistance. Inhibiting JAK/STAT3 blocks BCSC self...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2017.11.001
更新日期:2018-01-09 00:00:00
abstract::Faced with changing food availability, organisms adapt metabolism to survive. In a recent issue of Cell, Lin et al. (2009) described the acetylation of an extranuclear enzyme being regulated by acetyl-CoA. This finding connects nutrient availability, energy status, and survival. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.03.009
更新日期:2009-04-01 00:00:00
abstract::Cancer cells that leave their natural environment during metastatic spread must adapt to numerous stresses to survive. In this issue, Labuschagne et al. (2019) highlight one adaptive mechanism to overcome these stresses that involves cell clustering, which induces a hypoxic environment and metabolic rewiring to buffer...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.09.008
更新日期:2019-10-01 00:00:00
abstract::Intestinal microbial communities regulate a range of host physiological functions, from energy harvest and glucose homeostasis to immune development and regulation. Suez et al. (2014) recently demonstrated that artificial sweeteners alter gut microbial communities, leading to glucose intolerance in both mice and human...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2014.10.012
更新日期:2014-11-04 00:00:00
abstract::Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of m...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.01.003
更新日期:2015-02-03 00:00:00
abstract::Exercise produces many beneficial effects on brain health, in part by increasing hippocampal BDNF levels; however, the mechanism underlying BDNF gene regulation remains unknown. In this issue of Cell Metabolism, Wrann et al. (2013) show that exercise induces hippocampal Bdnf expression by stimulating expression of FND...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2013.10.008
更新日期:2013-11-05 00:00:00
abstract::Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA translation through PERK-mediated phosphorylation of eukaryotic initiation factor 2 on Ser51 of the alpha subunit (eIF2alpha). To elucidate the role of eIF2alpha phosphorylation, we engineered mice for conditional expression of homo...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.06.002
更新日期:2009-07-01 00:00:00
abstract::Circadian clocks, which underlie the daily rhythms in virtually all organisms, are entrained by diurnal changes in light, temperature, nutrients, and even sound. Simoni et al. (2014) demonstrate that diurnal variation in mechanical vibrations can reset circadian clock phase, providing a potential mechanism for integra...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2014.04.011
更新日期:2014-05-06 00:00:00
abstract::Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed th...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2014.03.020
更新日期:2014-04-01 00:00:00
abstract::The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.02.012
更新日期:2016-03-08 00:00:00
abstract::Zika virus is a pathogen that poses serious consequences, including congenital microcephaly. Although many viruses reprogram host cell metabolism, whether Zika virus alters cellular metabolism and the functional consequences of Zika-induced metabolic changes remain unknown. Here, we show that Zika virus infection diff...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.01.024
更新日期:2019-05-07 00:00:00
abstract::The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and resistance, we have generated mice with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency (IL-6Ralpha(L-KO) mice). These anima...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.06.011
更新日期:2010-09-08 00:00:00
abstract::The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here, we show that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues. In the inguinal depot, cold exposure resulted in elevated expression levels of brown-fat-ass...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.11.009
更新日期:2009-01-07 00:00:00
abstract::Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alpha-ketoglutarate (delivered in the form of a calcium salt, CaAKG) on healthspan and lifespan in C57BL...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.08.004
更新日期:2020-09-01 00:00:00
abstract::Impaired insulin secretion contributes to the pathogenesis of type 2 diabetes mellitus (T2DM). Treatment with the incretin hormone glucagon-like peptide-1 (GLP-1) potentiates insulin secretion and improves metabolic control in humans with T2DM. GLP-1 receptor-mediated signaling leading to insulin secretion occurs via ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.02.002
更新日期:2011-03-02 00:00:00
abstract::The circadian clock is a ubiquitous timekeeping system that organizes the behavior and physiology of organisms over the day and night. Current models rely on transcriptional networks that coordinate circadian gene expression of thousands of transcripts. However, recent studies have uncovered phylogenetically conserved...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.07.024
更新日期:2016-09-13 00:00:00
abstract::The final steps in the production of adenosine triphosphate (ATP) in mitochondria are executed by a series of multisubunit complexes and electron carriers, which together constitute the oxidative phosphorylation (OXPHOS) system. OXPHOS is under dual genetic control, with communication between the nuclear and mitochond...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2005.12.001
更新日期:2006-01-01 00:00:00
abstract::The biogenesis and function of the mitochondrial respiratory chain (RC) involve the organization of RC enzyme complexes in supercomplexes or respirasomes through an unknown biosynthetic process. This leads to structural interdependences between RC complexes, which are highly relevant from biological and biomedical per...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.01.015
更新日期:2012-03-07 00:00:00
abstract::miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression and the function of...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2019.07.011
更新日期:2019-10-01 00:00:00
abstract::Lipid droplets (LDs) are cellular storage organelles for neutral lipids that vary in size and abundance according to cellular needs. Physiological conditions that promote lipid storage rapidly and markedly increase LD volume and surface. How the need for surface phospholipids is sensed and balanced during this process...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.07.013
更新日期:2011-10-05 00:00:00
abstract::Glucagon drives hepatic gluconeogenesis and maintains blood glucose levels during fasting. The mechanism that attenuates glucagon action following refeeding is not understood. The present study demonstrates an increase in perivenous liver hypoxia immediately after feeding, which stabilizes hypoxia-inducible factor 2α ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.01.004
更新日期:2016-03-08 00:00:00
abstract::Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the pathogenesis of microvascular complications of diabetes, including diabetic nephropathy. However, the signaling pathways by which hyperglycemia leads to mitochondrial dysfunction are not fully understood. Here we examined the...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.01.009
更新日期:2012-02-08 00:00:00
abstract::Reporting in Cell Metabolism, Pflimlin et al. recently found no beneficial effect of PAHSAs on glucose control in mice on several high-fat diets. Kuda cautions that due to methodological differences, the data must be carefully reinterpreted, emphasizing that olive oil contains high amounts of FAHFAs, potentially maski...
journal_title:Cell metabolism
pub_type: 评论,信件
doi:10.1016/j.cmet.2018.09.006
更新日期:2018-10-02 00:00:00