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JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.

Abstract：

:Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we demonstrate that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (BCSCs) and cancer chemoresistance. Inhibiting JAK/STAT3 blocks BCSC self-renewal and expression of diverse lipid metabolic genes, including carnitine palmitoyltransferase 1B (CPT1B), which encodes the critical enzyme for fatty acid β-oxidation (FAO). Moreover, mammary-adipocyte-derived leptin upregulates STAT3-induced CPT1B expression and FAO activity in BCSCs. Human breast-cancer-derived data suggest that the STAT3-CPT1B-FAO pathway promotes cancer cell stemness and chemoresistance. Blocking FAO and/or leptin re-sensitizes them to chemotherapy and inhibits BCSCs in mouse breast tumors in vivo. We identify a critical pathway for BCSC maintenance and breast cancer chemoresistance.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Wang T,Fahrmann JF,Lee H,Li YJ,Tripathi SC,Yue C,Zhang C,Lifshitz V,Song J,Yuan Y,Somlo G,Jandial R,Ann D,Hanash S,Jove R,Yu H

doi

10.1016/j.cmet.2017.11.001

subject

Has Abstract

pub_date

2018-01-09 00:00:00

pages

136-150.e5

issue

1

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(17)30669-1

journal_volume

27

pub_type

杂志文章

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