当前位置： SCI文献检索 > Cell Metabolism期刊下所有文献 > The liver--a potential new player in islet regeneration?

The liver--a potential new player in islet regeneration?

Abstract：

:Pancreatic islet beta cell mass expands in response to certain physiological conditions such as pregnancy and obesity, but the signaling pathways involved are not well understood. Possible insights come from a newly described regulatory circuit through which obesity-enhanced kinase signaling in the liver triggers expansion of islet mass and enhanced insulin secretion.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Moss LG,Newgard CB

doi

10.1016/j.cmet.2008.12.009

subject

Has Abstract

pub_date

2009-01-07 00:00:00

pages

5-6

issue

1

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(08)00394-X

journal_volume

9

pub_type

杂志文章

相关文献

Cell Metabolism文献大全
  • CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance.

    abstract：:The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB(1)) has been shown to reduce body weight and to alleviate obesity-related metabolic disorders. An unsolved question is at which anatomical level CB(1) modulates energy balance ...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2010.02.015

    authors： Quarta C,Bellocchio L,Mancini G,Mazza R,Cervino C,Braulke LJ,Fekete C,Latorre R,Nanni C,Bucci M,Clemens LE,Heldmaier G,Watanabe M,Leste-Lassere T,Maitre M,Tedesco L,Fanelli F,Reuss S,Klaus S,Srivastava RK,Monory K

    更新日期：2010-04-07 00:00:00

  • Transgenerational inheritance of longevity: epigenetic mysteries abound.

    abstract：:Transgenerational inheritance of epigenetic characteristics in plants has been reported, whereas nongenetic persistence of complex phenotypes in animals is controversial. A recent report by Anne Brunet and colleagues describes a fascinating example of persistence across generations of extended life span in worm and ex...

    journal_title：Cell metabolism

    pub_type： 评论,杂志文章

    doi：10.1016/j.cmet.2011.12.012

    authors： Berger SL

    更新日期：2012-01-04 00:00:00

  • Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

    abstract：:Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lip...

    journal_title：Cell metabolism

    pub_type： 信件

    doi：10.1016/j.cmet.2019.05.014

    authors： Bekkering S,Stiekema LCA,Bernelot Moens S,Verweij SL,Novakovic B,Prange K,Versloot M,Roeters van Lennep JE,Stunnenberg H,de Winther M,Stroes ESG,Joosten LAB,Netea MG,Riksen NP

    更新日期：2019-07-02 00:00:00

  • ERRγ-A New Player in β Cell Maturation.

    abstract：:Glucose and hormone responsiveness of pancreatic β cells is acquired during postnatal maturation and is critical for appropriate insulin secretion. In a recent issue of Cell Metabolism, Yoshihara et al. (2016) report that estrogen-related receptor γ (ERRγ) promotes functional maturation of both mouse neonatal β cells ...

    journal_title：Cell metabolism

    pub_type： 评论,杂志文章

    doi：10.1016/j.cmet.2016.04.026

    authors： Shirakawa J,Kulkarni RN

    更新日期：2016-05-10 00:00:00

  • Leptin does not directly affect CNS serotonin neurons to influence appetite.

    abstract：:Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not expres...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2011.03.016

    authors： Lam DD,Leinninger GM,Louis GW,Garfield AS,Marston OJ,Leshan RL,Scheller EL,Christensen L,Donato J Jr,Xia J,Evans ML,Elias C,Dalley JW,Burdakov DI,Myers MG Jr,Heisler LK

    更新日期：2011-05-04 00:00:00

  • Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.

    abstract：:CD147 is a tumor-associated glycoprotein that regulates cell metabolism. However, CD147 methylation and its subsequent role in cancer cell metabolism remain unclear. Here, we detect CD147 di-methylation in 16 non-small-cell lung cancer (NSCLC) tissues using liquid chromatography-tandem mass spectrometry. CD147 is di-m...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2020.12.010

    authors： Wang K,Huang W,Chen R,Lin P,Zhang T,Ni YF,Li H,Wu J,Sun XX,Geng JJ,Zhu YM,Nan G,Zhang W,Chen X,Zhu P,Bian H,Chen ZN

    更新日期：2021-01-05 00:00:00

  • Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression.

    abstract：:Precise control of the thyroid hormone (T3)-dependent transcriptional program is required by multiple cell systems, including muscle stem cells. Deciphering how this is achieved and how the T3 signal is controlled in stem cell niches is essentially unknown. We report that in response to proliferative stimuli such as a...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2014.10.009

    authors： Dentice M,Ambrosio R,Damiano V,Sibilio A,Luongo C,Guardiola O,Yennek S,Zordan P,Minchiotti G,Colao A,Marsili A,Brunelli S,Del Vecchio L,Larsen PR,Tajbakhsh S,Salvatore D

    更新日期：2014-12-02 00:00:00

  • HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.

    abstract：:Glucagon drives hepatic gluconeogenesis and maintains blood glucose levels during fasting. The mechanism that attenuates glucagon action following refeeding is not understood. The present study demonstrates an increase in perivenous liver hypoxia immediately after feeding, which stabilizes hypoxia-inducible factor 2α ...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2016.01.004

    authors： Ramakrishnan SK,Zhang H,Takahashi S,Centofanti B,Periyasamy S,Weisz K,Chen Z,Uhler MD,Rui L,Gonzalez FJ,Shah YM

    更新日期：2016-03-08 00:00:00

  • Dynamics of an Aging Genome.

    abstract：:The genetic mechanisms mediating longevity and maximum lifespan of the human species are likely different than those explaining differences in life expectancy and healthspan across individuals. Both of these perspectives are important and can be separated and explored using genomic data. ...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2016.06.002

    authors： Telenti A,Perkins BA,Venter JC

    更新日期：2016-06-14 00:00:00

  • Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.

    abstract：:The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic ...

    journal_title：Cell metabolism

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.cmet.2017.02.009

    authors： Robinson MM,Dasari S,Konopka AR,Johnson ML,Manjunatha S,Esponda RR,Carter RE,Lanza IR,Nair KS

    更新日期：2017-03-07 00:00:00

  • Purloined mechanisms of bacterial immunity can cure muscular dystrophy.

    abstract：:Myriad strategies have been explored to compensate for the lack of dystrophin or to skip mutations that cause the lethal disease Duchenne muscular dystrophy (DMD). A new study shows that gene editing strategies used by bacteria can be applied in zygotes of a mouse model of DMD to correct the genetic defect that causes...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2014.11.011

    authors： Tidball JG,Bertoni C

    更新日期：2014-12-02 00:00:00

  • Transcriptional regulation of adipogenesis by KLF4.

    abstract：:While adipogenesis is known to be controlled by a complex network of transcription factors, less is known about the transcriptional cascade that initiates this process. We report here the characterization of Krüppel-like factor 4 (KLF4) as an essential early regulator of adipogenesis. Klf4 is expressed in 3T3-L1 cells...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2008.02.001

    authors： Birsoy K,Chen Z,Friedman J

    更新日期：2008-04-01 00:00:00

  • Branching out for detection of type 2 diabetes.

    abstract：:Type 2 diabetes is an epidemic disease worldwide, but it is difficult to predict its appearance in the general population. A recent study demonstrates that circulating concentrations of a small group of essential amino acids predict risk for diabetes, contributing to a recent resurgence of interest in these common ana...

    journal_title：Cell metabolism

    pub_type： 评论,杂志文章

    doi：10.1016/j.cmet.2011.04.003

    authors： Shah SH,Svetkey LP,Newgard CB

    更新日期：2011-05-04 00:00:00

  • Of Mice Not Men? Actions of Interleukin-6 on Glucose Tolerance.

    abstract：:In mice, interleukin-6 (IL-6) improves glucose tolerance via stimulation of glucagon-like peptide 1 (GLP-1) secretion. In this issue of Cell Metabolism, Lang Lehrskov et al. (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an ov...

    journal_title：Cell metabolism

    pub_type： 评论,杂志文章

    doi：10.1016/j.cmet.2018.05.013

    authors： McGlone ER,Tan TM

    更新日期：2018-06-05 00:00:00

  • In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding.

    abstract：:Nutritional and pharmacological stimuli can dramatically alter the cellular phenotypes in white adipose tissue (WAT). Utilizing genetic lineage tracing techniques, we demonstrate that brown adipocytes (BA) that are induced by β3-adrenergic receptor activation in abdominal WAT arise from the proliferation and different...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2012.03.009

    authors： Lee YH,Petkova AP,Mottillo EP,Granneman JG

    更新日期：2012-04-04 00:00:00

  • A macrophage sterol-responsive network linked to atherogenesis.

    abstract：:Cholesteryl ester accumulation by macrophages is a critical early event in atherogenesis. To test the hypothesis that sterol loading promotes foam cell formation and vascular disease by perturbing a network of interacting proteins, we used a global approach to identify proteins that are differentially expressed when m...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2010.01.003

    authors： Becker L,Gharib SA,Irwin AD,Wijsman E,Vaisar T,Oram JF,Heinecke JW

    更新日期：2010-02-03 00:00:00

  • Food for Thought: Revisiting the Complexity of Food Intake.

    abstract：:The ability of hormones such as insulin, leptin, and cholecystokinin to alter food intake is influenced by intricate interactions between homeostatic and non-homeostatic factors. Consequently, when administered exogenously, the likelihood of these hormones influencing food intake is probabilistic, leading to difficult...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2015.08.017

    authors： Woods SC,Begg DP

    更新日期：2015-09-01 00:00:00

  • Iron and diabetes risk.

    abstract：:Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failur...

    journal_title：Cell metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.cmet.2013.02.007

    authors： Simcox JA,McClain DA

    更新日期：2013-03-05 00:00:00

  • Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.

    abstract：:Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and skeletal muscle, which shares a common progenitor with BAT, are dramatically decreased in mice placed on a high-fat diet and in obese humans. Expressio...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2012.11.005

    authors： Derecka M,Gornicka A,Koralov SB,Szczepanek K,Morgan M,Raje V,Sisler J,Zhang Q,Otero D,Cichy J,Rajewsky K,Shimoda K,Poli V,Strobl B,Pellegrini S,Harris TE,Seale P,Russell AP,McAinch AJ,O'Brien PE,Keller SR,Cronig

    更新日期：2012-12-05 00:00:00

  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

    abstract：:CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or oxidative metabolic programs in vitro, requirements and mechanisms that control T cell glucose uptake and metabolism in viv...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2014.05.004

    authors： Macintyre AN,Gerriets VA,Nichols AG,Michalek RD,Rudolph MC,Deoliveira D,Anderson SM,Abel ED,Chen BJ,Hale LP,Rathmell JC

    更新日期：2014-07-01 00:00:00

  • PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.

    abstract：:SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availability. Here we show...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2011.03.004

    authors： Bai P,Cantó C,Oudart H,Brunyánszki A,Cen Y,Thomas C,Yamamoto H,Huber A,Kiss B,Houtkooper RH,Schoonjans K,Schreiber V,Sauve AA,Menissier-de Murcia J,Auwerx J

    更新日期：2011-04-06 00:00:00

  • Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.

    abstract：:Because MYC plays a causal role in many human cancers, including those with hypoxic and nutrient-poor tumor microenvironments, we have determined the metabolic responses of a MYC-inducible human Burkitt lymphoma model P493 cell line to aerobic and hypoxic conditions, and to glucose deprivation, using stable isotope-re...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2011.12.009

    authors： Le A,Lane AN,Hamaker M,Bose S,Gouw A,Barbi J,Tsukamoto T,Rojas CJ,Slusher BS,Zhang H,Zimmerman LJ,Liebler DC,Slebos RJ,Lorkiewicz PK,Higashi RM,Fan TW,Dang CV

    更新日期：2012-01-04 00:00:00

  • Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer.

    abstract：:VEGF (vascular endothelial growth factor) signaling inhibitors are widely used in different cancer types; however, patient selection remains a challenge. Analyses of samples from a phase III clinical trial in metastatic colorectal cancer testing chemotherapy versus chemotherapy with the small molecule VEGF receptors i...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2015.10.015

    authors： Pommier AJ,Farren M,Patel B,Wappett M,Michopoulos F,Smith NR,Kendrew J,Frith J,Huby R,Eberlein C,Campbell H,Womack C,Smith PD,Robertson J,Morgan S,Critchlow SE,Barry ST

    更新日期：2016-01-12 00:00:00

  • Light activates the adrenal gland: timing of gene expression and glucocorticoid release.

    abstract：:Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to improve metabolic and hormonal status of circadian rhythm sleep disorders, although its mechanism is poorly understood. In the present study, we revealed that light induces gene expression in the adrenal gland via the supra...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2005.09.009

    authors： Ishida A,Mutoh T,Ueyama T,Bando H,Masubuchi S,Nakahara D,Tsujimoto G,Okamura H

    更新日期：2005-11-01 00:00:00

  • Medicine in the Fourth Dimension.

    abstract：:The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective...

    journal_title：Cell metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.cmet.2019.06.019

    authors： Cederroth CR,Albrecht U,Bass J,Brown SA,Dyhrfjeld-Johnsen J,Gachon F,Green CB,Hastings MH,Helfrich-Förster C,Hogenesch JB,Lévi F,Loudon A,Lundkvist GB,Meijer JH,Rosbash M,Takahashi JS,Young M,Canlon B

    更新日期：2019-08-06 00:00:00

  • Pro- versus Anti-inflammatory Actions of HDLs in Innate Immunity.

    abstract：:High-density lipoproteins (HDLs) can inhibit inflammatory cytokine expression on innate immune cells, but sometimes they promote cytokine production as suggested in a recent article in Cell Metabolism by van der Vorst et al. (2017). Kopecky et al. point out that the origin, handling, and storage conditions of HDL prep...

    journal_title：Cell metabolism

    pub_type： 信件

    doi：10.1016/j.cmet.2017.04.007

    authors： Kopecky C,Michlits G,Säemann MD,Weichhart T

    更新日期：2017-07-05 00:00:00

  • Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss.

    abstract：:Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD(+)) exhibits axon-protective effects in cultured neurons; however, its ability to block degeneration in vivo has been difficult to establish due to i...

    journal_title：Cell metabolism

    pub_type： 杂志文章

    doi：10.1016/j.cmet.2014.11.003

    authors： Brown KD,Maqsood S,Huang JY,Pan Y,Harkcom W,Li W,Sauve A,Verdin E,Jaffrey SR

    更新日期：2014-12-02 00:00:00

  • Designing β Cells.

    abstract：:Diabetes is a growing epidemic, and many patients depend on insulin injections to control the disease and minimize long-term complications. In a recent manuscript published in Science, Xie et al. (2016) generate insulin-producing cells from a somatic embryonic kidney cell line through minimal genetic modification capa...

    journal_title：Cell metabolism

    pub_type： 评论,杂志文章

    doi：10.1016/j.cmet.2017.01.018

    authors： Hebrok M

    更新日期：2017-02-07 00:00:00

  • Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk.

    abstract：:The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing ne...

    journal_title：Cell metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.cmet.2012.10.007

    authors： Holmes E,Li JV,Marchesi JR,Nicholson JK

    更新日期：2012-11-07 00:00:00

  • What's the Mtrr with your grandparents?

    abstract：:Reduced folate levels can cause developmental defects and megaloblastic anemia. Padmanabhan et al. (2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descend...

    journal_title：Cell metabolism

    pub_type： 评论,杂志文章

    doi：10.1016/j.cmet.2013.09.016

    authors： Greer EL,Shi Y

    更新日期：2013-10-01 00:00:00