Abstract：
:Nutritional and pharmacological stimuli can dramatically alter the cellular phenotypes in white adipose tissue (WAT). Utilizing genetic lineage tracing techniques, we demonstrate that brown adipocytes (BA) that are induced by β3-adrenergic receptor activation in abdominal WAT arise from the proliferation and differentiation of cells expressing platelet-derived growth factor receptor alpha (PDGFRα), CD34, and Sca-1 (PDGFRα(+) cells). PDGFRα(+) cells have a unique morphology in which extended processes contact multiple cells in the tissue microenvironment. Surprisingly, these cells also give rise to white adipocytes (WA) that can comprise up to 25% of total fat cells in abdominal fat pads following 8 weeks of high-fat feeding. Isolated PDGFRα(+) cells differentiated into both BA and WA in vitro and generated WA after transplantation in vivo. The identification of PDGFRα(+) cells as bipotential adipocyte progenitors will enable further investigation of mechanisms that promote therapeutic cellular remodeling in adult WAT.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Lee YH,Petkova AP,Mottillo EP,Granneman JGdoi
10.1016/j.cmet.2012.03.009subject
Has Abstractpub_date
2012-04-04 00:00:00pages
480-91issue
4eissn
1550-4131issn
1932-7420pii
S1550-4131(12)00105-2journal_volume
15pub_type
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