Microglia Metabolic Breakdown Drives Alzheimer's Pathology.

Abstract:

:Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with amyloid beta acutely, and breakdown in both pathways chronically.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Bennett FC,Liddelow SA

doi

10.1016/j.cmet.2019.08.017

subject

Has Abstract

pub_date

2019-09-03 00:00:00

pages

405-406

issue

3

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(19)30446-2

journal_volume

30

pub_type

评论,杂志文章
  • High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function.

    abstract::Defects in insulin secretion play a central role in the pathogenesis of type 2 diabetes, yet the mechanisms driving beta-cell dysfunction remain poorly understood, and therapies to preserve glucose-dependent insulin release are inadequate. We report a luminescent insulin secretion assay that enables large-scale invest...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2014.12.010

    authors: Burns SM,Vetere A,Walpita D,Dančík V,Khodier C,Perez J,Clemons PA,Wagner BK,Altshuler D

    更新日期:2015-01-06 00:00:00

  • Metformin action: concentrations matter.

    abstract::Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of m...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.01.003

    authors: He L,Wondisford FE

    更新日期:2015-02-03 00:00:00

  • mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc.

    abstract::Aerobic glycolysis (the Warburg effect) is a core hallmark of cancer, but the molecular mechanisms underlying it remain unclear. Here, we identify an unexpected central role for mTORC2 in cancer metabolic reprogramming where it controls glycolytic metabolism by ultimately regulating the cellular level of c-Myc. We sho...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2013.09.013

    authors: Masui K,Tanaka K,Akhavan D,Babic I,Gini B,Matsutani T,Iwanami A,Liu F,Villa GR,Gu Y,Campos C,Zhu S,Yang H,Yong WH,Cloughesy TF,Mellinghoff IK,Cavenee WK,Shaw RJ,Mischel PS

    更新日期:2013-11-05 00:00:00

  • LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.

    abstract::Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the role of LRP5 in human...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.01.009

    authors: Loh NY,Neville MJ,Marinou K,Hardcastle SA,Fielding BA,Duncan EL,McCarthy MI,Tobias JH,Gregson CL,Karpe F,Christodoulides C

    更新日期:2015-02-03 00:00:00

  • Stem cells and oxidants: too little of a bad thing.

    abstract::Oxidants are thought to damage cells, and stem cells are viewed as particularly vulnerable to oxidative stress. Now, a new study (Morimoto et al., 2013) suggests that the self-renewal of certain stem cells may actually require reactive oxygen species (ROS). ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2013.06.007

    authors: Liu J,Finkel T

    更新日期:2013-07-02 00:00:00

  • ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition.

    abstract::Metabolic reprogramming plays an important role in supporting tumor growth. However, little is known about the metabolic alterations that promote cancer metastasis. In this study, we identify acyl-CoA thioesterase 12 (ACOT12) as a key player in hepatocellular carcinoma (HCC) metastasis. The expression of ACOT12 is sig...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.12.019

    authors: Lu M,Zhu WW,Wang X,Tang JJ,Zhang KL,Yu GY,Shao WQ,Lin ZF,Wang SH,Lu L,Zhou J,Wang LX,Jia HL,Dong QZ,Chen JH,Lu JQ,Qin LX

    更新日期:2019-04-02 00:00:00

  • Metabolic switches linked to pluripotency and embryonic stem cell differentiation.

    abstract::Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency. ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2015.02.011

    authors: Shyh-Chang N,Daley GQ

    更新日期:2015-03-03 00:00:00

  • MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2.

    abstract::Repression of mitochondrial respiration represents an evolutionarily ancient cellular adaptation to hypoxia and profoundly influences cell survival and function; however, the underlying molecular mechanisms are incompletely understood. Primarily utilizing pulmonary arterial endothelial cells as a representative hypoxi...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2009.08.015

    authors: Chan SY,Zhang YY,Hemann C,Mahoney CE,Zweier JL,Loscalzo J

    更新日期:2009-10-01 00:00:00

  • Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.

    abstract::Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-elusive metabolic circuitries. Here, we show that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autopha...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2014.02.010

    authors: Eisenberg T,Schroeder S,Andryushkova A,Pendl T,Küttner V,Bhukel A,Mariño G,Pietrocola F,Harger A,Zimmermann A,Moustafa T,Sprenger A,Jany E,Büttner S,Carmona-Gutierrez D,Ruckenstuhl C,Ring J,Reichelt W,Schimmel K,Lee

    更新日期:2014-03-04 00:00:00

  • High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.

    abstract::Adipose tissue plays an important role in storing excess nutrients and preventing ectopic lipid accumulation in other organs. Obesity leads to excess lipid storage in adipocytes, resulting in the generation of stress signals and the derangement of metabolic functions. SIRT1 is an important regulatory sensor of nutrien...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2012.07.003

    authors: Chalkiadaki A,Guarente L

    更新日期:2012-08-08 00:00:00

  • The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.

    abstract::Iron-dependent degradation of iron-regulatory protein 2 (IRP2) is a key event for maintenance of an appropriate intracellular concentration of iron. Although FBXL5 (F box and leucine-rich repeat protein 5) is thought to mediate this degradation, the role of FBXL5 in the control of iron homeostasis in vivo has been poo...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2011.07.011

    authors: Moroishi T,Nishiyama M,Takeda Y,Iwai K,Nakayama KI

    更新日期:2011-09-07 00:00:00

  • Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.

    abstract::Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR) in median eminenc...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2013.12.015

    authors: Balland E,Dam J,Langlet F,Caron E,Steculorum S,Messina A,Rasika S,Falluel-Morel A,Anouar Y,Dehouck B,Trinquet E,Jockers R,Bouret SG,Prévot V

    更新日期:2014-02-04 00:00:00

  • A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice.

    abstract::Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse that we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2015.02.004

    authors: Li P,Ruan X,Yang L,Kiesewetter K,Zhao Y,Luo H,Chen Y,Gucek M,Zhu J,Cao H

    更新日期:2015-03-03 00:00:00

  • Aging: all in the head?

    abstract::Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2007.08.007

    authors: Bartke A

    更新日期:2007-09-01 00:00:00

  • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals.

    abstract::Obese adipose tissue is characterized by infiltration of macrophages. We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue. This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-asso...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2008.08.015

    authors: Patsouris D,Li PP,Thapar D,Chapman J,Olefsky JM,Neels JG

    更新日期:2008-10-01 00:00:00

  • "Deepening" Insight on Skin Aging and Anti-microbial Immunity.

    abstract::Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired a...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2019.02.006

    authors: Kobayashi T,Nagao K

    更新日期:2019-03-05 00:00:00

  • Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory.

    abstract::While mesenchymal stem cells (MSCs) are rapidly cleared from the body following systemic transplantation, their therapeutic benefits typically persist. In this issue, Liu et al. (2015) reveal that the ability of transplanted MSCs to alleviate osteoporosis in systemic lupus erythematosus is maintained through epigeneti...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2015.09.019

    authors: Ng KS,Kuncewicz TM,Karp JM

    更新日期:2015-10-06 00:00:00

  • The Limits of Exercise Physiology: From Performance to Health.

    abstract::Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have been informed by stu...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2017.04.018

    authors: Gabriel BM,Zierath JR

    更新日期:2017-05-02 00:00:00

  • Enriching the Circadian Proteome.

    abstract::Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2016.12.014

    authors: Takahashi JS

    更新日期:2017-01-10 00:00:00

  • Metabolomics.

    abstract::Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and c...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2007.10.005

    authors: Idle JR,Gonzalez FJ

    更新日期:2007-11-01 00:00:00

  • Mitochondrial medicine: a metabolic perspective on the pathology of oxidative phosphorylation disorders.

    abstract::The final steps in the production of adenosine triphosphate (ATP) in mitochondria are executed by a series of multisubunit complexes and electron carriers, which together constitute the oxidative phosphorylation (OXPHOS) system. OXPHOS is under dual genetic control, with communication between the nuclear and mitochond...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2005.12.001

    authors: Smeitink JA,Zeviani M,Turnbull DM,Jacobs HT

    更新日期:2006-01-01 00:00:00

  • Putting the brakes on dietary fat breakdown.

    abstract::Dietary lipid digestion is critical for body fat storage control, but little is known about the regulation of genes involved in fat breakdown and absorption in the gastrointestinal tract. A Drosophila study (Sieber and Thummel, 2009 [this issue of Cell Metabolism]) now demonstrates that the orphan nuclear receptor DHR...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2009.11.004

    authors: Kühnlein RP

    更新日期:2009-12-01 00:00:00

  • Conserved metabolic regulatory functions of sirtuins.

    abstract::Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审

    doi:10.1016/j.cmet.2007.11.006

    authors: Schwer B,Verdin E

    更新日期:2008-02-01 00:00:00

  • Moving beyond GWAS and eQTL Analysis to Validated Hits in Chronic Kidney Disease.

    abstract::Genome-wide association studies (GWAS) have identified multiple chronic kidney disease (CKD)-associated single-nucleotide polymorphisms (SNPs) mainly localized to non-coding genomic regions. To understand which genes and which cell types are affected by these genetic variants, compartment-specific transcriptome, genom...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2018.12.009

    authors: Müller-Deile J,Jobst-Schwan T,Schiffer M

    更新日期:2019-01-08 00:00:00

  • Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding.

    abstract::Microglia play a crucial role in immune responses, including inflammation. Diet-induced obesity (DIO) triggers microglia activation and hypothalamic inflammation as early as 3 days after high-fat diet (HFD) exposure, before changes in body weight occur. The intracellular mechanism(s) responsible for HFD-induced microg...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2019.08.010

    authors: Kim JD,Yoon NA,Jin S,Diano S

    更新日期:2019-11-05 00:00:00

  • Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting.

    abstract::The delivery of blood-borne molecules conveying metabolic information to neural networks that regulate energy homeostasis is restricted by brain barriers. The fenestrated endothelium of median eminence microvessels and tight junctions between tanycytes together compose one of these. Here, we show that the decrease in ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2013.03.004

    authors: Langlet F,Levin BE,Luquet S,Mazzone M,Messina A,Dunn-Meynell AA,Balland E,Lacombe A,Mazur D,Carmeliet P,Bouret SG,Prevot V,Dehouck B

    更新日期:2013-04-02 00:00:00

  • Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance.

    abstract::Dietary restriction (DR) was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how DR limits cancer progression remains largely unknown. Here, we demonstrate that feeding mice a low-protein (Low PROT) isocaloric diet but not a low-carbohydrate (Low CHO) diet reduced tumo...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.02.009

    authors: Rubio-Patiño C,Bossowski JP,De Donatis GM,Mondragón L,Villa E,Aira LE,Chiche J,Mhaidly R,Lebeaupin C,Marchetti S,Voutetakis K,Chatziioannou A,Castelli FA,Lamourette P,Chu-Van E,Fenaille F,Avril T,Passeron T,Patterson

    更新日期:2018-04-03 00:00:00

  • Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

    abstract::Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lip...

    journal_title:Cell metabolism

    pub_type: 信件

    doi:10.1016/j.cmet.2019.05.014

    authors: Bekkering S,Stiekema LCA,Bernelot Moens S,Verweij SL,Novakovic B,Prange K,Versloot M,Roeters van Lennep JE,Stunnenberg H,de Winther M,Stroes ESG,Joosten LAB,Netea MG,Riksen NP

    更新日期:2019-07-02 00:00:00

  • A cholesterol toggle switch.

    abstract::Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcription factor SREBP plays a key role. Work in this issue (Radhakrishnan et al., 2008) employing direct measurement of endoplasmic reticulum cholesterol levels offers insights into the "switch" that controls this system w...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章

    doi:10.1016/j.cmet.2008.11.006

    authors: Hampton RY

    更新日期:2008-12-01 00:00:00

  • Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.

    abstract::Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post ...

    journal_title:Cell metabolism

    pub_type: 杂志文章

    doi:10.1016/j.cmet.2018.05.022

    authors: Wang QA,Song A,Chen W,Schwalie PC,Zhang F,Vishvanath L,Jiang L,Ye R,Shao M,Tao C,Gupta RK,Deplancke B,Scherer PE

    更新日期:2018-08-07 00:00:00